Serafim  Papadimitriou

Soledad A. Fernandez

Associate Professor

biography

Fernandez is currently a research associate professor and is Director of the Department of Biomedical Informatics' Center for Biostatistics. As part of her roles within OSU-BMI, she collaborates extensively with researchers in the Comprehensive Cancer Center (CCC) and Center for Clinical and Translational Science (CCTS), serving as the biostatistics core director on multiple awards and grants at OSU affiliated with these two centers. She has over 100 publications, a large portion of which are with cancer investigators within the CCC. 

 

Area of Interest

Her research interests are in applied biostatistical methods and high throughput experimental designs and analyses.


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Refereed Publications
1. Cooper J,Wei L, Fernandez SA, Minneci PC, and Deans K.Pre-operative prediction of surgical morbidity in children: comparison of five statistical models. Computers in Biology and Medicine. 2014. (Accepted November 2014)

2. Mathsyaraja H, Thies K, Taffany D, Deighan C; Liu T, Yu L, Fernandez SA, Shapiro CL, Otero J, Timmers C, Lustberg M, Chalmers J, Leone G, Ostrowski MC. CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. Oncogene. 2014 Sep22. doi:10.1038/onc.2014.294. [Epub ahead of print].

3. McCarty SK, Saji M, Zhang X, Kirschner LS, Fernandez SA, Ringel MD.BRAF activates and interacts with PAK to regulate cell motility. Endocrine Related Cancer. 2014. Vol. 21, issue 6. pii: ERC-14-0424. [Epub ahead of print] PMID: 25228413

4. Parrula C, Fernandez SA, Lairmore M, Niewiesk S. Success of measles virotherapy in ATL depends on type I interferon secretion and responsiveness. Virus Research(accepted May 2014).

5. White J, Hobbs L, and Fernandez SA Fructose Composition of Commercial HFCS-Sweetened Carbonated Beverages. International Journal of Obesity (Lond). 2014 May 6. doi: 10.1038/ijo.2014.73. [Epub ahead of print]. PMID: 24798032

6. Fleming JL, Dworkin AM, Allain DC, Fernandez SA, Wei L, Peters SB, Iwenofu OH, Ridd K, Bastian BC, Toland AE. Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma. International Journal of Cancer. 2014;134(1):244- 8. PMCID: 3831612.

7. Okemoto K, Kasai K, Wagner B, Haseley A, Meisen H, Bolyard C, Mo X, Wehr A, Lehman A, Fernandez SA, Kaur B, Chiocca EA. DNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas.” Clinical Cancer Research 2013 Nov 1;19(21):5952-9. doi: 10.1158/1078-0432.CCR-12-3588. Epub 2013 Sep 20

8. Guo Y, Pennell ML, Pearl DK, Knobloch TJ, Fernandez SA, Weghorst CM. The choice of reference gene affects statistical efficiency in quantitative PCR data analysis. Biotechniques. 2013 Oct; 55(4):207-9. PMID:24107253

9. Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg L, Sites E, Sandy A, Trimboli A, Fernandez SA, Eng C, Shapiro C, Leone G. Selective Roles of E2fs for ErbB2- and Mycmediated Mammary Tumorigenesis. Oncogene 2013 Nov 25. doi: 10.1038/onc.2013.511. [Epub ahead of print] PMID: 24276244. PMC4032808

10. Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez SA, Houghton P. Development, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma. Clinical Cancer Research2013 Dec 15;19(24):6716-29. doi: 10.1158/1078-0432.CCR-13-0842. Epub 2013 Oct 16. PMID: 24132923

11. Jadcherla SR, Chan CY, Fernandez SA and Splaingard M. Maturation of Upstream and Downstream Esophageal Reflexes in Human Premature Neonates: The Role of Sleep and Awake states. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2013 Nov;305(9):G649-68. doi: 10.1152/ajpgi.00002.2013

12. Kasai K, Nakashima H, Liu F, Kerr S, Wang J, Phelps M, Potter PM, Goins WB, Fernandez SA, Chiocca EA. Toxicology and Biodistribution Studies for MGH2.1, an Oncology Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs. Mol Ther Nucleic Acids. 2013 Aug6;2:e113.doi 10.1038/mtna.2013.38.

13. Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MC. Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer. PLoS One. 2013 Aug 16;8(8):e71533. doi: 10.1371/journal.pone.0071533 PMID: 23977064

14. Kannian P, Fernandez SA, Jones KS, Green PL.Human T lymphotropic virus type 1 (HTLV-1) SU residue 195 plays a role in determining the preferential CD4+ T cell immortalization/transformation tropism. Journal of Virology 2013;87(16):9344-52. PMCID: 3302488.

15. Bid HK, London CA, Gao J, Zhong H, Hollingsworth RE, Fernandez SA, Mo X, and Houghton P. Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and its Ligands as an Effective Anti-angiogenic Strategy. Clinical Cancer Research 2013;19(11):2984-94. PMCID: 3674221.

16. Price R, Song JE, Bingmer K, Kim T-H, Yi J-Y, Nowicki N, Mo X, Hollon T, Murnan E, Alvarez- Beckenridge C, Fernandez SA, Kaur B, Rivera A, Oglesbee, Cook C, Kwon C-H, Chiocca E. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Research 2013;73(11):3441-50.

17. Wu C, Fernandez SA, Criswell T, Chidiac T, Guttridge D, Villalona-Calero M, Bekaii-Saab T. Disrupting cytokine signaling in pancreatic cancer: A phase I/II study of Etanercept in combination with Gemcitabine in patients with advanced disease. Pancreas 2013;42(5):813-8. PMCID: 3664263.

18. Jadcherla S, Chan C-Y, Moore R, Fernandez SA, Shaker R. Physiology of Esophageal Sensory-Motor Malfunctions in Neonatal Neurological illness. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15;304(6):G574-82. doi: 10.1152/ajpgi.00404.2012. Epub 2013 Jan 17. PMID: 24008357

19. Bertino EM, Bekaii-Saab T, Fernandez SA, Diasio RB, Karim NA, Otterson GA, Villalona- Calero MA. A phase II study of modulated-capecitabine and docetaxel in chemonaive patients with advanced non-small cell lung cancer (NSCLC). Lung Cancer 2013;79(1):27-32. PMCID: 3549571.

20. Wang Y, Nowicki MO, Arnold WD,Fernandez SA, Mo X,Wechuk J, Krisky D, Goss J,Wolfe D,Popvich PG, Lawler S, Chiocca EA. Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain. Gene Therapy 2013;20(7):742-50.

21. Jadcherla SR, Parks VN, Peng J, Dzodzomenyo S, Fernandez SA, Shaker R, Splaingard M. Esophageal sensation in premature human neonates: temporal relationships and implications of aerodigestive reflexes and electrocortical arousals. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G134-44.doi: 10.1152/ajpgi.00067.2011. Epub 2011 Aug 18. PMID: 21852361.

22. Jadcherla SR, Peng J, Moore R, Saavedra J, Shepherd E, Fernandez SA, Erdman SH, DiLorenzo C. Impact of personalized feeding program in 100 NICU infants: pathophysiology-based approach for better outcomes. J Pediatr Gastroenterol Nutr. 2012 Jan; 54(1):62-70. doi: 10.1097MPG 0b013e3182288766. PMID: 21694638.

23. Bergese S, Viloria A, Uribe A, Antor A, and Fernandez SA. Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial. Trials 2012, 13:130 doi:10.1186/1745-6215-13-130

24. Luchin AI, Nadella MVP, Thudi NK, Dirksen WP, Gulati P, Fernandez SA, Rosol TJ. AUrich elements in the 3’-UTR regulate the stability of the 141 amino acid isoform of parathyroid hormone-related protein mRNA. Molecular and Cellular Endocrinology 2012;364(1-2):105-12. PMCID: 3529141.

25. Mella C, Suarez-Arrabal MC, Lopez S, Stephens J, Fernandez SA, Hall M, Ramilo O, Mejias A. Innate Immune Dysfunction is Associated with Enhanced Disease Severity in Infants with Severe Respiratory Syncytial Virus Bronchiolitis. Journal of Infectious Diseases (2012) Dec 27 doi: 10.1093/infdis/jis721. PMID:23204162 [PubMed - as supplied by publisher]