Serafim  Papadimitriou

Bipasha Bose

Assistant Professor

Deralakatte, Mangalore

biography

Dr Bipasha Bose obtained her Ph.D. degree in Applied Biology (Molecular Carcinogenesis) from Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India in 2004. She has a more than 11 years of post-PhD research experience working in Stem Cell Biology, in academia and industry in India, Belgium and Singapore. Dr Bose holds key skills in the field of clinical, as well as, R and D grade stem cells. Her noted contributions to the field of regenerative medicine involve her co-work with the scientists for deriving human embryonic stem cells (hESC) for the first time from the Indian subcontinent, differentiation of hESC into functional insulin producing β islets and their pre-clinical translation, differentiation of hESC into functional hepatocytes.
She has also contributed in the field of adult stem cell biology and proven the myogenic potential of aged muscle stem cells and perivascular mesenchymal stem cells, hepatocyte differentiation from Multipotent Adult Progenitor cells. Her contribution in the field of basic biology of stem cells has proven the pluripotent conversion of myostatin- null muscle stem cells without using reprogramming factors. She has contributed to several publications and book chapters as the lead author in the peer-reviewed journals and books of international repute. Dr. Bose also has two patents to her credit. Currently, Dr Bose is working in Yenepoya Research Centre, Yenepoya University. Her present focus is on establishing R and D scale human and mouse stem cell laboratories, guiding Ph.D students in her area of expertise of basic biology of stem cells and stem cell therapy for diabetes, liver diseases and muscle disorders

 

Area of Interest

1)Stem cell therapy for diabetes
2)Liver diseases and muscle disorders


top publication

1) Shenoy PS*, Bose B#*,. Enhancing the stemness/plasticity of dental stem cells using growth factors, small molecules and scaffolds for tissue engineering. 2015. Accepted for publication with recommended minor revisions in Jacobs Journal of Regenerative Medicine, Vol.1(1), 002 (Inaugural Issue). http://www.jacobspublishers.com/images/Regenarative/J_J_Regener_Med_1_1_002.pdf (*Equally contributing authors, #Corresponding author).

2) Bose B*, Shenoy PS, Reza MM, McFarlane CD, Sharma, M and Kambadur, R. 2014. Plasticity of muscle derived stem cells to undergo pluripotent conversion without pluripotency factors or small molecules. Cytotherapy, Vol. 16, Issue 4, Supplement: S71. (Published as selected abstracts presented in 20th Annual Meeting of International Society for Cellular Therapy, Paris, April 24-26, 2014. DOI: http://dx.doi.org/10.1016/j.jcyt.2014.01.262 (Journal Impact Factor-3.1).Citations-Not yet cited

3) Shenoy PS, Bose B, Sharmar M and Kambadur R. 2014. Myogenic propensities of cells obtained from liver by preplating. Cytotherapy, Vol. 16, Issue 4, Supplement: S71. (Published as selected abstracts presented in 20th Annual Meeting of International Society for Cellular Therapy, Paris, April 24-26, 2014. DOI: http://dx.doi.org/10.1016/j.jcyt.2014.01.262 (Journal Impact Factor-3.1).Citations-Not yet cited

4) Bose B#**, Shenoy PS#. 2014. Stem Cell versus Cancer and cancer stem cell: intricate balance decides their respective usefulness or harmfulness in the biological system. Journal of Stem Cell Research and Therapy, Vol.4, 173: doi: 10.4172/2157-7633.1000173 (Open Access article available freely on Google) (Journal Impact Factor-3.81).Citations-Not yet cited ** Corresponding author. #Equally contributing authors

5) Shenoy PS*, Bose B*, Sharma M, McFarlane C, Kambadur R. 2014. Lack of Myostatin reduces MyoD gene uptake and subsequent myogenesis in primary mouse fibroblasts isolated from skeletal muscle. Accepted for publication in Journal of Cellular Biochemistry, June 6. doi 10.1002/jcb.24860. [Epub ahead of print]. *Equally contributing authors (Journal Impact Factor-3.368)Citations-Not yet cited

6) Bose B#**, Shenoy PS**#. Non Insulin producing cell line, MIA PaCa-2 is rendered insulin producing in vitro via mesenchymal epithelial transition. Journal of Cellular Biochemistry, 2013, Volume 114 (7):1642-52 doi:10.1002/jcb.24506 (Online May 09, 2013). ** Corresponding authors. #Equally contributing authors (Journal Impact Factor-3.368)Citations-Not yet cited This paper was selected as one of the top articles in Global Medical Discovery (http:// globalmedicaldiscovery.com) [ISSN 1929-8536] in June 2013 issue This paper was also selected for the cover page title ‘Mesenchymal Epithelial Transition” (MET) of Journal of Cellular Biochemistry, 2013, Volume 114 (7):1642-52

7) Bose B**, Shenoy PS, Konda S and Wangikar P. Human embryonic stem cell differentiation into insulin secreting beta cells for diabetes, Cell Biology International 2012, Oct 02 Online, Volume 36 (11): 1013–1020 (Journal Impact Factor-1.635) Citations-30 ** Corresponding author

8) Bose, B. 2012.Past, present and future of stem cells in regenerative medicine, its associated risks and promise to mankind. Asia Pacific Biotech news, Vol 16, No 3, March 2012:24-27 (Journal Impact Factor-Non Impacted, ISSN:0219-0303, Published by World Scientific Publishing, Singapore), Citations-Not yet cited

9) Roelandt P*,Pauwelyn KA*, Sancho-Bru P*, Subramanian K*, Bose B, Ordovas L, ,Vanuytsel K, Geraerts M, Firpo M, Devos R, Nevens F, Hu W-S, Verfaillie CM. Human Embryonic and Rat Adult Stem Cells with Primitive Endoderm-Like Phenotype Can Be Fated to Definitive Endoderm, and Finally Hepatocyte-Like Cells (2010) PLOS One Volume 5(8): e12101. doi:10.1371/journal.pone.0012101, August 11, 2010 (Journal Impact Factor-4.4) Citations-53

10)Roelandt P,Pauwelyn KA, Sancho-Bru P, Subramanian K, Bose B., Shimizu T., Vanuytsel K., Hu W-S, Nevens F.,Verfaillie CM. Universal Hepatocyte Differentiation Protocol for Multipotent Adult Progenitor cells, Embryonic and Induced Pluripotent Stem Cells. Journal of Hepatology, Vol. 50, Supplement1, April 2009, S313 (Published as meeting abstract of the International Liver Congress TM 2009. 44th Annual Meeting of the European Association for the Study of the Liver, EASL location:Copenhagen date:22-26 April 2009) (Journal Impact Factor-9.5).Citations-Not yet cited

11) Mandal A, Tipnis T, Pal R, Ravindran G, Bose B, Patki A, Rao MS, Khanna A. Characterisation and in-vitro differentiation potential of a new human embryonic stem cell line, ReliCellhES1. Differentiation, 2006,Volume 74 : 81 - 90 (Journal Impact Factor-3.146). Citations-40

12) Bose B, Gour RR, Motiwale L, Roles KVKR. Differential role of MAP kinases in transformation of Syrian hamster embryo fibroblasts by Malachite Green. Indian Journal of Experimental Biology 2006, Vol. 44 : 693-698 (Journal Impact Factor- 1.2.) Citations-01

13) Bose B, Motiwale L, Goud RS, Rao KVKR. Decreased phosphoactive ERKs and JNKs in Malachite Green (MG) transformed Syrian hamster embryo (SHE) fibroblasts are associated with increased p38 kinase: Possible therapeutic importance Chemotherapy. 2006; 52 (4):210-14 (Journal Impact Factor-2.00)Citations-Not cited yet

14) Bose B, Rao KVKR. DNA damage and G2/M arrest in Syrian hamster embryo cells during Malachite green exposure are associated with elevated phosphorylation of ERK1 and JNK1. Cancer Letters 2005 Dec 18; 230 (2):260-70 (Journal Impact Factor- 5.016) Citations-46

• Bose B, Motiwale L, Gupta A, Goud RS, Rao KVKR. Hyperphosphorylation of extracellular regulated kinase 2 (ERK 2) and inhibition of JNK 2 phosphorylation are associated with increased S-phase during transformation of Syrian hamster embryo cells by Malachite Green. Cell Biol. International. 2004;28(12):875-83 (Journal Impact Factor-1.6). Citations-Not yet cited