Serafim  Papadimitriou

Fuzheng Guo

Principal Investigator

biography

Dr. Fuzheng Guo, PhD, is a principal investigator at the Neurology Department of UC Davis and the Institute for Pediatric Regenerative medicine of Shriners Hospital for Children. The research interest in Dr. Guo's laboratory has been focused on the biology and pathology of glial cells and the interaction of oligodendroglial-vascular cells in the central nervous system using a combination of genetic, molecular, cellular and proteomic approaches applied to both in vitro and in vivo models

 

Area of Interest

The research interest in Dr. Guo's laboratory has been focused on the biology and pathology of glial cells and the interaction of oligodendroglial-vascular cells in the central nervous system using a combination of genetic, molecular, cellular and proteomic approaches applied to both in vitro and in vivo models


top publication

1. Xiao X, Zhao X, Liu J, Guo F, Liu D, He D (2003) Discovery of laryngeal carcinoma by serum proteomic pattern analysis. Sci China C Life Sci. 47(3):219-23.[PMID:15524278]
2. Xiao X, Liu D, Tang Y, Guo F, Xia L, Liu J, He D (2003-2004) Development of proteomic patterns for detecting lung cancer. Dis Markers19(1):33-9 [PMID: 14757945].
3. Guo F, Nian H, Zhang H, Huang L, Tang Y, Xiao X, He D (2006) Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model. Proteomics 6:3075-3086 [PMID: 16619303].
4. Zhang Z, Chen J, Guo F, He L, Wu Y, Zeng C, Xiao X, He D (2008) A high-temporal resolution technology for dynamic proteomic analysis based on 35S labeling. PLoS One. 20;3(8):e2991. [PMID: 18714357].
5. Guo F, Ma J, McCauley E, Bannerman P, Pleasure D (2009) Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci 29:7256-7270 [PMID: 19494148].
6. Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D (2010) Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci 30:12036-12049. [PMID: 20826667].
7. Wu Y, Guo F, Liu J, Xiao X, Huang L, He D (2011) Triple labeling with three thymidine analogs reveals a well-orchestrated regulation of hepatocyte proliferation during liver regeneration. Hepatol Res. 41:1230-9. [PMID: 21917088].
8. Guo F, Maeda Y, Ma J, Delgado M, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D (2011) Macroglial plasticity and genetic origin of reactive astrocytes in experimental autoimmune encephalomyelitis. J Neurosci 31:11914-28. [PMID: 21849552].
9. Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D (2012) Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to EAE or their normal development. J Neurosci 32:639-45. [PMID: 22238099].
10. Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D (2012) PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci. 32:12152-64. [PMID: 22933798].
11. Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, and Guo F (2013). Adenomatous Polyposis Coli Regulates Oligodendroglial Development. J Neurosci 33: 3113-30. [PMID: 23407966].
12. Moreno M, Guo F, Ko EM, Bannerman P, Soulika A, Pleasure D (2013). Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci 510x:638-7. [PMID: 23294494].
13. Chung SH, Guo F, Jiang P, Pleasure DE, Deng W (2013) Olig2/Plp-positive progenitor cells give rise to Bergmann glial in the cerebellum. Cell Death and Disease, Mar 14;4:e546. doi: 10.1038/cddis.2013.7 [PMID: 23492777].
15. Ko EM, Ma J, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika A, Pleasure D (2014) Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflam 11, 105. [PMID: 24924222].
16. Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika A, Pleasure D (2014) Conditionalablation of astroglial CCL2 suppresses CNS accumulation of m1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci 34, 8175-8185. [PMID: 24920622].
17. Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty AC, Krishnamurthy A, Tsai MK, Covarrubias D, Wong AT, Francis DD, Sapolsky RM,Palmer TD, Pleasure D, Kaufer D (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014 Dec;19(12):1275-83. [PubMed PMID: 24514565].
18. He J, Hao S, Zhang H, Guo F, Huang L, Xiao X, He D (2015) Chronological protein synthesis in regenerating rat live. Electrophoresis. 36:1622-32. [PMID: 25873423].
19. Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure D (2015) The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci 35:3756-63. [PMID: 25740506].
20. Guo F, Bannerman P, Mills Ko E, Miers L, Xu J, Burns T, Li S, Freeman E, McDonough JA, Pleasure D (2015). Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Ann Neurol doi: 10.1002/ana.24392. [PMID: 25712859].