Pathogenic Mechanisms of Idiopathic and Hypoxic Pulmonary Hypertension
Cellular and Molecular Mechanisms of Hypoxic Pulmonary Vasoconstriction
Electrophysiology of Ion Channels in Smooth Muscle and Endothelial Cells
Calcium Signaling and Intracellular Calcium Regulation
Smooth Muscle Cell Migration, Proliferation, and Apoptosis
Pulmonary Circulation and Vascular Physiology and Pharmacology
Pathogenic Role of Progenitor Cells in Pulmonary Vascular Disease

1. Fernandez RA, Wan J, Song S, Smith KA, Gu Y, Tauseef M, Tang H, Makino A, Mehta D, Yuan JX. Upregulated STIM2, TRPC6 and Orai2 Contribute to the Transition of Pulmonary Arterial Smooth Muscle Cells from a Contractile to Proliferative Phenotype.Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C581-93.
2. Tang H,Ayon RJ, Yuan JX. New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis. EMBO Mol Med.2015 Apr 7;7(6):689-91
3. Gong H, Rehman J, Tang H, Wary K, Zhang M, Mittal M, Chatturvedi P, Vogel SM,Malik AB.HIF2α Signaling Inhibits Adherens Junctional Disruption in Acute Lung Injury. J Clin Invest.2015 Feb;125(2):652-64
4. Chen T, Zhou G, Zhou Q, Tang H, Ibe JC, Gou D, Comhair SA,Erzurum SC, Yuan JX,Raj JU. Suppression of miR 17-92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDLIM5 and inhibition of TGF-β3/Smad3 Pathway.Am J RespirCrit Care Med.2015 Mar 15;191(6):678-92.
5. Tang H, Chen J, Fraidenburg DR, Sysol J, Song SS, Garcia J G, Machado RF, Makino A, Yuan JX. Phenotypic Characterization for Rodent Models of Pulmonary Hypertension. (In preparation). 2015.
6. Tang H,Yamamura A, Fraidenburg DR, Song SS, Chen J, Gu Y, Pohl NM, Yamamura H, Perez LH, Mcdermott KM, Black SM, Garcia J G, Makino A, Yuan JX. CaSR Functionally Interact with TRPC6 to Regulate Cytosolic [Ca2+] in the Development and Progression of Pulmonary Hypertension. (In preparation). 2015.
7. Tang H, Fernandez RA, Yuan JX. miRNA208/Mef2 and TNF-α in Right Ventricular Dysfunction: The Transition from Hypertrophy to Failure. Circ Res.2015 Jan 2;116(1):6-8.
8. Smith KA, Voiriot G, Tang H,Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. Notch-mediated activation of TRPC6 and enhancement of store-operated Ca2+ entry contribute to hypoxic pulmonary vasoconstriction and pulmonary hypertension. Am J Respir Cell Mol Biol. 2015 Jan 8.
9. Tang H, Chen J, Fraidenburg DR, Sysol J, Song SS, Garcia JG, Machado RF, Makino A, Yuan JX. Akt1, not Akt2, contributes to the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L208-20.
10. Chen J, Tang H,Sysol J, Liliana MV, Shioura KM, Chen T, Gorshkova I, Wang L, Huang L, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF. The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway Promotes Pulmonary Vascular Remodeling. Am J RespirCrit Care Med. (Co-first Author) 2014 Nov 1;190(9):1032-43.
11. Song S, Yamamura A, Yamamura H, Ayon R, Smith K, Tang H, Makino A, Yuan JX. Flow Shear Stress Enhances Intracellular Ca 2 Signaling in Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary Arterial Hypertension. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C373-83.
12. Zimnicka AM, Tang H,Guo Q, Kuhr FK, Oh MJ, Wan J, Chen J, Smith KA, Fraidenburg DR, Choudhury MS, Levitan I, Machado RF, Kaplan JH, Yuan JX. Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS One.2014 Mar 10;9(3):e90544.
13. Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H,Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX. Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. Am J Physiol Lung Cell Mol Physiol.2013 Jul 15;305(2):L154-64.
14. Ibe JC, Zhou Q, Chen T, Tang H, Yuan JX, Raj JU, Zhou G. Adenosine monophosphate-activated protein kinase is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension. Am J Respir Cell Mol Biol2013 Oct;49(4):609-18.
15. Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX. Functional characterization of voltage-dependent Ca2+ channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS. Am J Physiol Cell Physiol.2013 Jun 1;304(11):C1042-52.
16. Das M, Fessel J, Tang H, West J. A process-based review of mouse models of pulmonary hypertension. Pulm Circ.2012 Oct;2(4):415-33.
17. Liu X, Ma B, Malik AB, Tang H, Yang T, Sun B, Wang G, Minshall RD, Li Y, Zhao Y, Ye RD, Xu J. Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immuno.2012 Mar 25;13(5):457-64.
18. Lei Y, Tang H,Zhong H, Xie H, Liu R, Feng M, Zou B. Labeling of hematopoietic stem cells by Tat peptide conjugated quantum dots for cell tracking in mouse body. J Nanosci Nanotechnol. 2012 Sep;12(9):6880-6.
19. Chen J, Tang H, Hay N, Xu J, Ye RD.Akt isoforms differentially regulate neutrophil functions. Blood.2010 May 27;115(21):4237-46.
20. Di A, Kawamura T, Gao XP, Tang H,Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB.A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. J Biol Chem.2010 May 21;285(21):15848-57.
21. Lei Y, Tang H, Feng M, Zou B. Applications of fluorescent quantum dots to stem cell tracing in vivo. J Nanosci Nanotechnol. 2009 Oct;9(10):5726-30.
22. Lei Y, Tang H, Zhou C, Zhang T, Feng M, Zou B. Incorporating fluorescent quantum dots into water-soluble polymer. J Lumin.128(3): 277-281, 2008
23. Tang H, Yao H, Wang G, Wang Y, Li YQ, Feng M. NIR Raman spectroscopic investigation of single mitochondria trapped by optical tweezers. Opt Express.2007 Oct 1;15(20):12708-16.
24. Lei Y, Tang H, Yao L, Yu R, Feng M, Zou B. Applications of mesenchymal stem cells labeled with Tat peptide conjugated quantum dots to cell tracking in mouse body.Bioconjug Chem. 2008 Feb;19(2):421-7.
25. Yao A, Tang H, Wang Y, Feng M, Zhou R. Inhibition of the activating signals in NK92 cells by recombinant GST-sHLA-G1a chain. Cell Res.2004 Apr;14(2):155-60.
26. Tian X, Li Z, Liu Y, Wang Y, Tang H, Feng M.Immunoinhibitory effect of soluble HLA-G1 on the cytotoxicity of NK92 cells.Prog Nat Sci.2003 13(3):191-195,
ABSTRACTS:
27. Tang H, Chen J, Song S, Machado R, Zimnicka A, Smith K, Yuan JX. (2013) Activation of Akt/mTOR pathway contributes to enhanced pulmonary artery smooth muscle cell proliferation in patients and animals with pulmonary arterial hypertension. Journal of investigative medicine 61 (4), 780-780. (Presented Abstract)
28. Chen J, Shahrara S, Yamaura A, Justin SR, Tang H,Xie L, Fahs A, Song S, Garcia JG. Machado RF.(2013) Interleukin-7 and IL-7 receptor are novel mediators in the development of pulmonary hypertension I humans in huamans and mice. Journal of investigative medicine 61 (4), 766-766 (Presented Abstract)
29. Sundivakkam P, Tang H, Fernandez R, Drennan A, Yuan JX. (2012)Transient receptor potential channels (TRPC) contribute to an enhanced endothelial cell proliferation and irreversible vascular remodeling associated with the development of pulmonary arterial hypertension (PAH)The FASEB Journal 27 (Presented Abstract)
30. Tang H, Chen J, Drennan A, Fraidenburg D, Garcia JG, Machado RF, Makino A, and Yuan JX.Distinct Roles of Akt Isoforms in the Development of Hypoxia Induced Pulmonary Hypertension. Circulation. 2013;128:A18437 (Oral Presentation)
31. Tang H, Song S, Drennan A, Fernandez R, Chen J, Yuan JX. The crucial role of calcium sensing receptor for hypoxia-induced pulmonary arterial hypertension in mice.The FASEB Journal 28 (1 Supplement), 889.2 (Presented Abstract)
32. Tang H, Chen J, Makino A, Fraidenburg DR, Sysol JR, Machado RF, Yuan JX. Conditional Deletion of Beta-Catenin in Smooth Muscle Cells Fail to Affect The Development of Pulmonary Hypertension. Journal of Investigative Medicine 62 (4), 743-744 (Presented Abstract)
33. Tang H, Chen J, Drennan A, Fraidenburg D, Song S, Sysol J, Smith K, Machado R, Makino A, Yuan JX. Akt/mtor Signaling Contributes To The Development Of Pulmonary Arterial Hypertension. Am J RespirCrit Care Med 2014:A5559 (Presented Abstract)
34. Song S, Tang H, Smith K, Makino A, Yuan JX. Shear stress enhance intracellular Ca2+in PASMC from patients with idiopathic pulmonary arterial hypertension. The FASEB Journal 2014; 28 (1 Supplement), 1090.13 (Presented Abstract)
35. Sysol J, Chen J, Tang H, Reddy V, Yuan JX, Natarajan V, Machado. Sphingosine-1-Phosphate Receptor 2 Is Elevated In Patients With Pulmonary Arterial Hypertension And Regulates S1p-Induced Pulmonary Artery Smooth Muscle Cell Proliferation. Am J RespirCrit Care Med 2014:A4776 (Presented Abstract)
36. Zhou G, Zhou Q, Chen T, Tang H, Li J, Chen J, Raychaudhuri P, Yuan JX, Raj JU. Suppression Of Foxm1 In Smooth Muscle Cells Attenuates Hypoxia-Induced Pulmonary Hypertension. Am J RespirCrit Care Med 2014:A3332 (Presented Abstract)
37. Zhou G, Chen T, Zhou Q, Tang H, Yuan J, Raj JU. MiR-17~ 92 promotes hypoxia-induced pulmonary hypertension by regulating proliferation and contraction of pulmonary arterial smooth muscle cells. The FASEB Journal 28 (1 Supplement), LB779 (Presented Abstract)
38. Chen T, Zhou Q, Tang H, Yuan J, Raj JU, Guofei Zhou. (2015) MiR-17~92 Regulates HIF Activity Through Targeting PHD2 in PASMC.Am J RespirCrit Care Med2015: A5950 (Presented Abstract)
39. Zhou F, Zhou Q, Chen T, Tang H, Yuan J, Sznajder J, Raj JU. Fibroblast-Specific Knockout of Von Hippel-Lindau Protein Induces Spontaneous Pulmonary Hypertension in Mice. Am J RespirCrit Care Med2015; A1918 (Presented Abstract)
40. Chen J, Sysol JR, Huang LS, Sridhar A, Dong Y, Tang H, Garcia JG. Yuan JX. Natarajan V, Machado RF. Conditional SphK1 Deficiency in Smooth Muscle Cells, But Not Endothelial Cells, Protects Against Hypoxia-Mediated Pulmonary Hypertension in Mice. Am J RespirCrit Care Med2015: A1919 (Presented Abstract)
41. Fraidenburg DR, Tang H, Chen J, Drennan AR, Machado RF, Yuan JX. A Novel Formulation of Vasoactive Intestinal Peptide, PGC-VIP, Attenuates the Development of Pulmonary Hypertension.Am J RespirCrit Care Med 2015; A1966 (Presented Abstract)
42. Fernandez, R, Jimenez-Perez, L, Song S, Tang H, Yuan JX. The Functional Coupling of CaSR and TRPC6 Contributes to Enhanced Proliferation in Pulmonary Arterial Smooth Muscle Cells. FASEB J 2015 29:662.17 (Presented Abstract)
43. Tang H, Chen J, Fraidenburg D, Gu Y, Garcia JG, Makino A, Yuan JX. Raptor and Rictor Both Contribute to the Development and Progression of Pulmonary Arterial Hypertension. FASEB J 2015 29:662.17 (Presented Abstract)