Serafim  Papadimitriou

Mahran S. Abdel-Rahman

Associate Professor


Mahran S. Abdel-Rahman completed his PhD. pharmacology, Faculty of Pharmacy, Assiut University, in Egypt. He is a Associate Professor pharmacology & Toxicology,College of Pharmacy, TaibahUniversity, KSA. His research interest reflects wide range of publications.


Area of Interest

1. Clinicalpharmacologystudies on healthyvolunteers and patients. 2. Experimentalpharmacology on CNS acting drugs. 3. BiochemicalPharmacology.

top publication

1. El-Bitar H.I., Afifi A.M. and Abdel-Rahman M.S.: Cardiac effects of certain antidepressants. The XI Sci. Confer. Egypt. Soc. Basic Med Sci., El_Minofia, Egypt, March 1989.
2. M. Abdel-Rahman, F. Wosch, S. Harder and B.G. Woodcock: Interaction between verapamil and vincristine binding to plasma proteins. Int. J Clin. Pharmacol. Ther. And Toxicol. 1992, 30 (11): 536.
3. B.G. Woodcock, M. Abdel-Rahman, F. Wosch and S. Harder: Effect of D,L-verapamil, Verapamil enantiomers and verapamil metabolites on the binding of vinncristine to alpha1-acid glycoprotein. Eur. J. Cancer. 1993, 29 A (4): 559- 561.
4. B.G. Woodcock, M. Abdel-Rahman, S. Harder and W. Ganser: Kumulation von vincristine beiintaktenzelllen und ihre modulation durch verapamil und alph1-Glykoprotein. 3rd annual meeting of clinical pharmacology Society, Bad-Nauheim, Germany, September 1993.
5. M. Abdel-Rahman, S. Harder, C. Lucas and B.G. Woodcock: Comparison of the effects of verapamil and S9788 on the binding of vincristine to alpha1-acid glycoprotein. 3rd annual meeting of clinical pharmacology Society, Bad-Nauheim, Germany, September 1993.
6. M. S. Abdel-Rahman, A. Assi, F. Osman and B.G. Woodcock: Effect of verapamil and alpha1-acid glycoprotein on vincristine accumulation by lymphocytes from CLL patients and cell lines. J. Egypt. Soc. Pharmacol. Exp. Ther. 1995, 14 (1): 495-519.
7. Safwat M. Mangoura, Mohamed M. Khalifa, Hassan H. Abou-Rahma and Mahran S. Abdel-Rahman: The effects of some heavy metals on the hepatic microsomal coumarin hydroxylase activity in intact and gonadectomized mice. J. Egypt. Soc. Toxicol. 1996, 17: 57-62.
8. Mahran S. Abdel-Rahman, Essam E. Abdel-Hakiem, Zeinareh and SafwatMangoura: Experimental evaluation of anticonvulsant properties of propofol in tow models of seizures in laboratory mice. Egypt. J. Anesth. 1996, 12 (1): 1-11
9. E El-Desoky, M. S. Abdel-Rahman, O.M. Moustafa, M.R. kandil and A.M. Afifi: Optimization of antiepileptic drug therapy through measurement of plasma level of antiepileptic drugs (AEDS). Ther. Drug Monit J. 1997, 19 (5): 567 Abstract no 79. and in J. Egypt Soc. Pharmacol. Exp. Ther 1997, 16 (2): 747-763.
10. Safia A. Tohami, Eman M. Khedr and Maharn S Abdel-Rahman: Effect of epilepsy and antiepileptic drugs on cognitive function, P2 and P3 components in newly diagnosed epilepsies. Egypt. J NeurolPsychiatNeurosurg, 1997, 34 (1): 89-96.
11. Mamdouh M. Anwar and Mahran S. Abdel-Rahman: Effect of propofol on perception of pain in mice: mechanism of action. Comp. Biochem. Physiol. 1998, 120A (2): 249-253.
12. Mahran S. Abdel-Rahman, Ehab S. El-Desoky, Salah-EldinAmry, and Abdel-HalimM.Afifi: Serum level monitoring of digoxin in cardiac patients attending Assiut university hospitals: utility in therapy optimization. Assiut Med. J. 1999, 23 (3): 25-34.
13. Mahmoud M. Abdel-Rahman, Mahran S. Abdel-Rahman, AbdelazimAssi and Saida Abdel-RagalAly. Modulation of the antiepileptic activity of sodium valproate by lithium chloride against pentylene-tetrazole and strychnine-induced seizures in mice. Assiut Med. J. 1999, 23 (3): 59-72.
14. Assi Abdel-Azim and Abdel-RahmanMahran S. Analgesic effects of Tramadol-Diclofenac combination and their interaction with psychostimulant drugs in mice and rats. 11th world congress on pain. August 21-26, 2005, Sydney, Australia. IASP press, Abstract number 571-P177.
15. Sohier M. Kamel, Saida A. Ali, M.M. Abdel-Rahman and Mahran S, Abdel-Rahman. Modulation of antiepileptic activity of sodium valproate by lithium chloride against kainic acid and bicuculline-induced seizures. Assiut Med. J, .July 2001, 25 (3): 23-38.
16. Mahran S. Abdel-Rahman, Enjy A. Abdel-Rahman and AbelazeemAssi. Possible pharmacodynamic interactions between CNS stimulant and analgesics. Assiut Med. J2008, 32 (1): 237-249.
17. Adel G. El-Shemi, Mahran S. Abd El-Rahaman and Mohamed H. Abd El-Sattar. Renoprotective effects of thymoquinone, a compound derived from nigella sativa oil, on gentamicin-induced nephrotoxicity in rats. Assiut Med J.2009, 33 (3):11-22.
18. Adel Galal A. El-Shemi and Mahran S. Abd El-Rahaman. Hepatoprotective effects of rolipram on Experimental murine model of immune-mediated Fulminant hepatitis.. Assiut Med. J.2009. 33 (3): 23-32.
19. Basel A. Abd El-Wahab, Mahran S. Abd El-rahman, Mohamed M. Abd El-latif. Enhanced delivery of baclofen through blood brain barrier using poly (butyl cyanoacrylate) nanoparticles coated with polysorbate-80The International Conference for Nanotechnology Industries. KingSaudUniversity, Ryiadh5-7/4/2009
20. Alaaeldin A. Elkoussi, Marwa A Ahmed and Mahran S. Abdel-Rahman. Pharmacological and toxicological evaluation of the locally abused Glue (Kolla) in rats. Assiut Med. J. 2010, 34 (3): 59-70.
21. EnasNashaat, Abdel-Alim M Abdela-Alim, SamialGalal, Abdel-Naser Al-Shorbagy and Mahran S. Abdel-Rahman. Synthesis of new 4,5-3(2H) pyridazinone derivatives and their cardiotonic, hypotesive and platelet aggregation inhibition activities. Arch. Pharm. Res., 2010, 33 (1): 25-36.
22. Ahmed O. Abdel-Zaher, Mahran S. Abdel-Rahman and Fahmy M El-Wasae. Blockade of nitric oxide overproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice. Neurochem. Res. 2010, 35: 1557-1565.
23. Ahmed O Abdel-Zaher, Mahran S Abdel-Rahmanand Fahmy M Elwasei. Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: Role of nitric oxide and oxidative stress. Neurotoxicology, Dec 2011, 32(6):725-33.
24. Ahmed S. Ali, Mahran S. Abdel-Rahman, Ab Fatah AbRahman and Osman H. Osman. Basic principles of therapeutic drug monitoring. J ApplBiopharm&Pharmacokin,2013, 1: 87-95.

1. "Chronic Diseases, Overcrowding Related Diseases and their Therapy" organized by general directorate of health affairs in Madinah Region. Held at Al-MadinahAlmunwarahsept, 15-16, 2012.
2. Minisymbosium on "Drugs and the kidenys" Heldat Al-Madinah Al-Munwara on 5 February, 2013.
3. Minisymbosium on "Drugs and Cardiology" Heldat Al-Madinah Al-Munwara on 5, June, 2013.
4. Minisymbosium on "Advanced training on Excell Program" HeldatTaibahUniversity, Al-Madinah Al-Munwara, KSA on 24, April, 2014.
5. First symbosium on "Recent trends in pharmaceutical sciences" College of pharmacy, Taibah University, Ministry of higher education, Held at Al-Madinah Al-Munwara on April 13-14, 2013.
6. Minisymbosium on "the Black Seed ( NigellaSativa): a cure of everyailment" organized and hosted by MABL EAJAZ chair for scientific miracles in propheticmedicineheldatTaibahuniversity, Al-MAdinah Al-Munwarah, KSA on May, 2014.