Serafim  Papadimitriou

Syed Rizvi

Associate Professor

biography

Dr. Syed A. A. Rizvi pursued his M.S and Ph.D as a combined degree program at the Center for Biotechnology and Drug Design, Department of Chemistry, Georgia State University (GSU), Atlanta, GA. While working at GSU, Dr. Rizvi was trained in the areas of Analytical Chemistry, Separation Sciences, Bioanalysis, Surfactant Chemistry, Chiral Separations of the Drugs, Trace Level Analysis (Forensic Chemistry) of Drugs in human body fluids (led to a US and International patent). He has published a number of peer-reviewed articles in top ranking journals and two book chapters. Currently he is an Associate Professor in the Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, United States.

 

Area of Interest

Pharmaceutical formulations (direct compressed tablets, topical and liquid); Ionic liquid formation and cocrystallization of the pharmaceutical compounds; Nano and micro-encapsulation of the drugs for targeting and controlled release; Multistep synthesis of small organic molecules; Pharmaceutical analysis (forensics and method development); Design and synthesis of novel monomeric and polymeric surfactants for separation of chiral and achiral compounds in micellar electrokinetic chromatography (MEKC); Method development and validation for separations of achiral and chiral compounds utilizing MEKC-UV/MS and HPLC-UV-MS; Application of cryogenic high resolution scanning electron microscopy (Cryo-HRSEM) and analytical ultracentrifuge for characterization of polymeric surfactants; Chemical transformation of pharmacologically active compounds using microbial whole cultures; Isolation and pharmacology of compounds from fungal metabolites and medicinal plants.


top publication

1) Rizvi, S. A. A.; Shamsi, S. A. “Polymeric alkenoxy amino acid surfactants: I. Highly selective class of molecular micelles for chiral separation of β-blockers” Electrophoresis2003, 24, 2514-2526 - DOI: 10.1002/elps.200305516.
2) Rizvi, S. A. A.; Akbay, C.; Shamsi, S. A. “Polymeric alkenoxy amino acid surfactants: II. Chiral separations of β-blockers with multiple stereogenic centers” Electrophoresis2004, 25, 853-860 - DOI: 10.1002/elps.200305762.
3) Rizvi, S. A. A.; Simons, D. N.; Shamsi, S. A. “Polymeric alkenoxy amino acid surfactants: III. Chiral separations of binaphthyl derivatives” Electrophoresis2004, 25, 712-722 - DOI: 10.1002/elps.200305774.
4) Iqbal, R.; Rizvi, S. A. A.; Akbay, C.; Shamsi, S. A. “Chiral separations in microemulsion electrokinetic chromatography Use of micelle polymers and microemulsion polymers” J. Chromatogr. A 2004, 1043, 291-302 - DOI: 10.1016/j.chroma.2004.05.085.
5) Akbay, C.; Rizvi, S. A. A.; Shamsi, S. A. “Simultaneous Enantioseparation and Tandem UV-MS Detection of Eight β-Blockers in Micellar Electrokinetic Chromatography Using a Chiral Molecular Micelle” Anal. Chem 2005, 77, 1672-1683 - DOI: 10.1021/ac0401422, (Figure 9 in this publication is reprinted in the text book "Quantitative Chemical Analysis" by Daniel C. Harris, p. 616, Figure 26-33, 7th edition).
6) Iqbal, R.; Rizvi, S. A. A.; Shamsi, S. A. “Glycine-based polymeric surfactants with varied polar head group: I. Synthesis, characterization, and application in micellar electrokinetic chromatography” Electrophoresis2005, 26, 4127-4137 - DOI: 10.1002/elps.200500361.
7) Rizvi, S. A. A.; Shamsi, S. A. “Polymeric alkenoxy amino acid surfactants: IV. Effects of hydrophobic chain length and degree of polymerization of molecular micelles on chiral separation of β-blockers” Electrophoresis2005, 26, 4172-4186 - DOI: 10.1002/elps.200500199.
8) Hou, J.; Rizvi, S. A. A.; Zheng, J.; Shamsi, S. A. “Application of polymeric surfactants in micellar electrokinetic chromatographyelectrospray ionization mass spectrometry of benzodiazepines and benzoxazocine chiral drugs” Electrophoresis2006, 27, 1263-1275 - DOI: 10.1002/elps.200500610.
9) Apkarian, R, P.; Shamsi, S, A.; Rizvi, S, A.; Benian, G.; Neal, A, L.; Taylor, J, V.; Dublin, S, N. “Cryoetch And Cryo-planing For Low Temperature HRSEM: SE-I Imaging Of Hydrated Multicellular, Microbial And Bioorganic Systems” Microscopy and Microanalysis2006,12 (supplement S02), 1120-1121–DOI: 10.1017/S1431927606063823.
10) Rizvi, S. A. A.; Shamsi, S. A. “Synthesis, Characterization, and Application of Chiral Ionic Liquids and Their Polymers in Micellar Electrokinetic Chromatography” Anal. Chem 2006, 78, 7061-7069 - DOI: 10.1021/ac060878u.
11) Norton, D.; Rizvi, S. A. A.; Shamsi, S. A. “Capillary electrochromatography-mass spectrometry of cationic surfactants” Electrophoresis2006, 27, 4273-4287 - DOI: 10.1002/elps.200600301.
12) Zheng, J.; Hou, J.; Rizvi, S. A. A.; Shamsi, S. A. “Photopolymerized Sol-Gel Monolithic Column for Capillary Electrochromatography (CEC) and CEC Coupled to Atmospheric Pressure Photoionization Mass Spectrometry” J. Liq. Chromatogr. & Rel. Technol., 2007, 30, 43-57 - DOI: 10.1080/10826070601034238.
13) Rizvi, S. A. A.; Zheng, J.; Apkarian, R, P.; Dublin, S. N.; Shamsi, S. A. “Polymeric Sulfated Amino Acid Surfactants: A Class of Versatile Chiral Selectors for Micellar Electrokinetic Chromatography (MEKC) and MEKC-MS” Anal. Chem 2007, 79, 879-898 - DOI: 10.1021/ac061228t.
14) Hou, J.; Zheng, J.; Rizvi, S. A. A.; Shamsi, S. A. “Simultaneous chiral separation and determination of ephedrine alkaloids by MEKC-ESI-MS using polymeric surfactant I: Method development” Electrophoresis2007, 28, 1352-1363 - DOI: 10.1002/elps.200600415.
15) Rizvi, S. A. A.; Shamsi, S. A. “Polymeric alkenoxy amino acid surfactants: V. Comparison of carboxylate and sulfate head group polymeric surfactants for enantioseparation in MEKC” Electrophoresis2007, 28, 1762-1778 – DOI: 10.1002/elps.200600483.
16) Rizvi, S. A. A.; Shi, L.; Lundberg, D.; Menger F. M. “Unusual Aqueous-Phase Behavior of Cationic Amphiphiles with Hydrogen-Bonding Headgroups” Langmuir2008, 24, 673-677 – DOI: 10.1021/la7037608.
17) FrišÄić, T.; Childs, S. L.; Rizvi, S. A. A.; Jones, W. “The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome” CrystEngComm 2009, 11, 418-426 -DOI: 10.1039/B815174A, (Cover article, included among CrystEngComm's most highly rated articles).
18) Menger, F. M.; Shi, L.; Rizvi, S. A. A. “Re-evaluating the Gibbs Analysis of Surface Tension at the Air/Water Interface” J. Am. Chem. Soc. 2009, 131, 10380-10381 – DOI: 10.1021/ja9044289.
19) Do, D. P.; Pai, S. B.; Rizvi, S. A. A.; D’Souza, M. J. “Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy” Int. J. Pharm. 2010, 386, 114-121–DOI: 10.1016/j.ijpharm.2009.11.009.
20) Menger, F. M.; Shi, L.; Rizvi, S. A. A. “Additional Support for a Revised Gibbs Analysis” Langmuir2010, 26, 1588-1589 - DOI: 10.1021/la9043914.
21) Menger, F. M.; Shi, L.; Rizvi, S. A. A. “Self-assembling systems. Mining a rich vein” J. Colloid Interface Sci., 2010, 344, 241-246 - DOI: 10.1016/j.jcis.2010.01.031, (Invited feature and cover article).
22) Akbay, C.; Hoyos, Y.; Arslan, H.; Rizvi, S. A. A. "Cationic gemini surfactants as pseudostationary phases in micellar electrokinetic chromatography. Part I: Effect of head group” J. Chromatogr. A 2010, 1217, 5279-5287 - DOI: 10.1016/j.chroma.2010.05.055.