Serafim  Papadimitriou

Ming Chen

Visiting Associate Professor

biography

Dr. Ming Chen completed his Ph.D in Protein Chemistry and Proteomics from Beijing Proteome Research Center. He completed a postdoctoral fellowship in molecular cardiology at Thomas Jefferson University in Philadelphia. Then, he joined faculty at Tianjin Institute of Hygiene and Environmental Medicinea Research Associate. At present, he is a Visiting Associate Professor in Guangxi Botanical Institute of Medicinal Plants.

 

Area of Interest

Dr. Chen’s research focuses on vascular biology and proteomics. He used proteomics strategy combined biochemistry to study vascular and heart diseases such as vascular angiogenesis, permeability regulatory pathway, hypertrophy and heart failure.


top publication

1. Chen M., Qu X., Zhang Z., Wu H., Qin X., Li F., Liu Z., Tian L., Miao J., Shu W. Crosstalk between Arg methylation and Ser phosphorylation modulates ASK1 activation in endothelial cells. Mol.Biol.Cell. 2016, 27(8):1358-1366
2. Chen M., Yi B., Zhu N., Wei X., Zhang G., Huang S., Sun J. Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633. Cardiovasc Res. 2016, 109(1):141-50
3. Chen M., Yi B., Sun J. Inhibition of cardiomyocyte hypertrophy by protein arginine methyltransferase 5. J. Biol. Chem. 2014, 289(35):24325-24335
4. Qin Q. #, Chen M. #, Yi B., Li P., You X., Yang P., Sun J. Orphan nuclear receptor Nur77 is a novel negative regulator of ET-1 expression in vascular endothelial cells. Journal of Molecular and Cellular Cardiology. 2014 (77):20-28 (#co-first author)
5. Jiang Y.#, Ying W.#, Wu S.#, Chen M.#., Guan W., Yang D., Song Y., Liu X., Li J., Hao Y., Sun A., Geng C., Li H., Mi W., Zhang Y., Zhang J., Chen X., Li L., Gong Y., Li T., Ma J., Li D., Yuan X., Zhang X., Xue X., Zhu Y., Qian X., He F., et al. First insight into human liver proteome from PROTEOMESKY-LIVERHu 1.0, a publicly available database. J Proteome Res. 2010, 9(1): 79-94 (#co-first author)
6. Chen M., Yang B., Ying W., He F., Qian X. Annotation of non-synonymous single poly- morphisms in human liver proteome by mass spectrometry. Protein Pept Lett. 2010, 17(3):277-286
7. Wang X., Gong J., Liu X., Zhan R., Kong R., Zhao Y., Wan D., Leng X., Chen M.,# Qian L.# Expression of uncoupling protein3 in mitochondria protects against stress-induced myocardial injury: a proteomic study. Cell Stress Chaperones. 2010, 15(6):771-779 (#corresponding author)
8. Chen M.,# Wang Y., Zhao Y., Gong J., Yang Z., Qian L.# Dynamic proteomic and metabolomic analysis reveal dysfunction and subclinical injury of rat liver during restraint stress. Biochim Biophys Acta – Proteins & Proteomics. 2009, 1794(12): 1751-1765 (#corresponding author)
9. Chen M., Ying W., Song Y., Liu X., Yang Bi., Wu S., Jiang Y., Cai Y., He F., Qian X. Analysis of human liver proteome using replicate shotgun strategy. Proteomics. 2007, 7 (14): 2479-2488
10. Chen M., Wang L., Gao X., Gong J., Qian X., Qian L. Effect of auxiliary electrospray on liquid chromatography–electrospray ionization-mass spectrometry analysis. Journal of Chinese Mass Spectrometery Society. 2009, 30(6): 321-326
11. Chen M., Ying W., Fang Q., Sun W., He F., Qian X. The evaluation and application of a label-free quantitative proteomic strategy based on LC-ESI-MS/MS. Progress in Biochemistry and Biophysics. 2008, 35 (4): 401-409
12. Chen M., Ying W., Qian X. Progress and challenge of large scale proteome express profile. Chemistry of Life. 2007, 27(1): 17-20
13. Chen M., Shen W., Ruan H., Xu L. Effects of nitric oxide on root growth and its oxidative damage in wheat seeding under salt stress. Journal of Plant Physiology and Molecular Biology. 2004, 30(5): 569-576
14. Chen M., Shen W., Xu L. 14-3-3 Protein. Chemistry of Life. 2002, 22(5): 445-448
15. Qi J., Yang P., Yi B., Huo Y., Chen M., Zhang J., Sun J. Heat shock protein 90 inhibition by 17-DMAG attenuates abdominal aortic aneurysm formation in mice. Am J Physiol Heart Circ Physiol. 2015, 308(8):H841-52
16. Yan G., Zhu N., Huang S., Yi B., Shang X., Chen M., Wang N., Zhang G., Talarico JA, Tilley DG., Gao E., Sun J. Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation. Mol Cell Biol. 2015, 35(19):3312-23
17. Huo Y., Yi B., Chen M., Wan N., Guo C., Sun J. Induction of Nur77 by hyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation. Biochem Pharmacol. 2014, 92(4):590-8
18. Liu Y., Zhang J., Yi B., Chen M., Qi J., Yin Y., Lu X., Jasmin J F., Sun J. Nur77 suppresses pulmonary artery smooth muscle cell proliferation through inhibition of the STAT3/Pim-1/NFAT pathway. Am J Respir Cell Mol Biol. 2014, 50(2):379-388
19. Li P., Zhu N., Yi B., Wang N., Chen M., You X., Zhao X., Qin Y., Sun J. MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation. Circ Res. 2013, 113(10):11117-1127
20. O-Uchi J., Jhun B, Hurst S., Bisseto S., Gross P., Chen M., Kettlewell S., Park J., Oyamada H., Smith G.., Murayama T., Sheu S. Over-expression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. AJP-Heart and Circulatory Physiology. 2013, 305(12):H1736-1751
21. Zhou L., Ying W., Han Y., Chen M., Yan Y., Li L., Zhu Z., Zheng Z., Jia W., Yang R., Qian X. A proteome reference map and virulence factors analysis of Yersinia pestis 91001. J Proteomics. 2012, 75(3):894-907
22. Sui S., Wang J., Yang B., Song L., Zhang J., Chen M., Liu Ji., Lu Z., Cai Y., Zhu Y., He F., Qian X. Phosphoproteome analysis of human Chang liver cell by using SCX and a complementary mass spectrometric strategy. Proteomics. 2008, 8(10): 2024-2034