Serafim  Papadimitriou

Kim Jonghan

Assistant Professor

biography

Biography

 

Area of Interest

My research interests center around the characterization of absorption, distribution, and metabolism of drugs and metals, including essential metals (iron, zinc and manganese) and toxic heavy metals (lead, cadmium, mercury and arsenic), and metal-induced toxicity in the context of environmental exposure and genetic susceptibility (gene-environment interactions).


top publication

1. Sundling K, Craciun G, Schultz IR, Hook SE, Nagler JJ, Cavileer TD, Verducci JS, Liu Y, Kim J, Hayton WL (2014). Modeling the endocrine control of vitellogenin production in female rainbow trout. Math Biosci Eng 11:621-639.
2. Mohanty S, Kim J, Ganesan LP, Phillips GS, Robinson JM, Anderson CL (2013). Abundant intracellular IgG in enterocytes and endoderm lacking FcRn. PLoS One 8:e70863. PMID: 23923029, PMCID: PMC3726603.
3. Byrne SL, Buckett PD, Kim J, Luo F, Sanford J, Chen J, Enns C, Wessling-Resnick M (2013). Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo. PLoS One 8:e70199. PMID: 23894616. PMCID: PMC3720890.
4. Jia X, Kim J, Veuthey T, Lee C-H, Wessling-Resnick M (2013). Glucose metabolism in the Belgrade rat, a model of iron-loading anemia. Am J Physiol: GI Liver Physiol 304:G1095- G1102. PMID: 23599042. PMCID: PMC3680718.
5. Kim J, Buckett PD, Wessling-Resnick M (2013). Absorption of manganese and iron in a mouse model of hemochromatosis. PLoS One 8:e64944. PMID: 23705020. PMCID: PMC3660331.
6. Kim J, Jia X, Buckett PD, Liu S, Lee C-H, Wessling-Resnick M (2013). Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia. FASEB J 27:1657-1663. PMID: 23241313. PMCID: PMC3606537.
7. Ganesan LP, Kim J, Wu Y, Mohanty S, Philips GS, Birmingham DJ, Robinson JM, Anderson CL (2012). FcγRIIb on liver sinusoidal endothelium clears small immune complexes. J Immunol 189:4981-4988. PMID: 23053513.
8. Kim J, Li Y, Buckett PD, Böhlke M, Thompson KJ, Takahashi M, Maher TJ, Wessling-Resnick M (2012). Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency. PLoS One 7:e33533. PMID: 22479410. PMCID: PMC3316579. 9. Li Y, Kim J, Buckett PD, Böhlke M, Maher TJ, Wessling-Resnick M (2011). Severe post-natal iron deficiency alters emotional behavior and dopamine levels in the prefrontal cortex of young male rats. J Nutr 141:2133-2138. PMID: 22013197. PMCID: PMC3223871.
10. Claus Henn BG, Kim J, Wessling-Resnick M, Téllez-Rojo MM, Jayawardene I, Ettinger AS, Hernandez-Avila M, Schwartz J, Christiani DC, Hu H, Wright RO (2011). Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models. Environ Health 10:97. PMID: 22074419. PMCID: PMC3248860.
11. Ganesan LP, Mohanty S, Kim J, Clark KR, Robinson JM, Anderson CL (2011). Rapid and efficient clearance of blood-borne virus by liver sinusoidal endothelium. PLoS Pathog 7: e1002281. PMID: 21980295. PMCID: PMC3182912.
12. Molina RM, Phattanarudee S, Kim J, Thompson KJ, Wessling-Resnick M, Maher TJ, Brain JD (2011). Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring. Neurotoxicology 32:413-422. PMID: 21458486. PMCID: PMC3109129.
13. Kim J, Molina RM, Donaghey TC, Buckett PD, Brain JD, Wessling-Resnick M (2011). Influence of DMT1 and iron status on inflammatory responses in the lung. Am J Physiol Lung Mol Physiol 300:L659-L665. PMID: 21278260. PMCID: PMC3075097.
14. Sani SN, Henry K, Böhlke M, Kim J, Stricker-Krongrad A, Maher TJ (2010). The effects of drug transporter inhibitors on the pharmacokinetics and tissue distribution of methotrexate in normal and tumor-bearing mice: a microdialysis study. Cancer Chemother Pharmacol 66:159- 169. PMID: 19816684.
15. Mohanty S*, Kim J*, Ganesan LP, Phillips GS, Hua K, Jarjoura D, Hayton WL, Robinson JM, Anderson CL (2010). IgG is transported across the mouse yolk sac independently of FcγRIIb. J Reprod Immunol 84:133-144. *Contributed equally. PMID: 20015554. PMCID: PMC3050502.
16. Kim J, Mohanty S, Ganesan LP, Hua K, Jarjoura D, Hayton WL, Robinson JM, Anderson CL (2009). FcRn in the yolk sac endoderm of mouse is required for IgG transport to fetus. J Immunol 182:2583-2589. PMID: 19234152, PMCID: PMC2676880.
17. Kim J, Bronson CL, Wani MA, Oberyszyn TM, Mohanty S, Chaudhury C, Hayton WL, Robinson JM, Anderson CL (2008). β2-microglobulin deficient mice catabolize IgG more rapidly than FcRn-α-chain deficient mice. Exp Biol Med 233:603-609. PMID: 18375831.
18. Kim J, Hayton WL, Robinson JM, Anderson CL (2007). Kinetics of FcRn-mediated recycling of IgG and albumin in human: Pathophysiology and therapeutic implications using a simplified mechanism-based model. Clin Immunol 122:146-155. PMID: 17046328, PMCID: PMC2791364.
19. Chaudhury C*, Kim J*, Mehnaz S, Wani MA, Oberyszyn TM, Bronson CL, Mohanty S, Hayton WL, Robinson JM, Anderson CL (2006). Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr 136:2993-2998. *Contributed equally. PMID: 17116709.
20. Kim J, Hayton WL, Schultz IR (2006). Modeling the brain-pituitary-gonad axis in salmon. Mar Environ Res 62:S426-S432. PMID: 16716390.
21. Wani MA, Haynes L, Kim J, Bronson CL, Chaudhury C, Mohanty S, Waldmann TA, Robinson JM, Anderson CL (2006). Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant β2-microglobulin gene. Proc Natl Acad Sci U S A 103:5084-5089. PMID: 16549777, PMCID: PMC1458798.
22. Kim J, Bronson CL, Hayton WL, Radmacher MD, Roopenian DC, Robinson JM, Anderson CL (2006). Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. Am J Physiol: GI Liver Physiol 290:G352-G360. PMID: 16210471.
23. Li D, Jang SH, Kim J, Wientjes MG, Au JL (2003). Enhanced drug-induced apoptosis associated with P-glycoprotein overexpression is specific to antimicrotubule agents. Pharm Res 20:45-50. PMID: 12608535.
24. Kim J, Kim EJ, Han KS, Chang MS, Lee MG (1999). Gastrointestinal first-pass effect of YJA- 20379-8, a new reversible proton pump inhibitor, in rats. J Pharm Pharmacol 51:1031-1036. PMID: 10528986.
25. Chung SY, Han KS, Kim HJ, Kim J, Chang MS, Lee MG (1999). Gastrointestinal absorption of a new reversible proton pump inhibitor, YJA-20379-8, and its pharmacokinetics after oral administration in acetic acid-induced gastric ulcer in rats. J Pharm Pharmacol 51:1025-1030. PMID: 10528985.