Serafim  Papadimitriou

Hongbin SUN

Associate Director and Professor


Dr. Sun got his Ph.D. degree in Medicinal Chemistry from China Pharmaceutical University. After postdoctoral research in Shanghai Institute of Organic Chemistry (Chinese Academy of Sciences, 1995-1997),Aachen University(Germany, 1997-1998),and University of Florida (USA, 1998-2001), he joined Metabolex, Inc. as a scientist (2001-2003). Currently, he is"Yangtze River Scholar" Distinguished Professor and Director of Center for Drug Discovery at China Pharmaceutical University. His membership includes Regional Editorial member of “Recent Patents on Anti-Cancer Drug Discovery” (2008-2015), Editorial member of “Drug Discoveries & Therapeutics”, Editorial member of “Medicinal Chemistry”, Editorial member of “Chinese Journal of Medicinal Chemistry”, etc. He has published more than 170 papers in peer-reviewed journals, and is the inventor of more than 30 patent applications.


Area of Interest

1)Basic research and drug discovery in the areas of metabolic disease and cancer
2)Transcriptional regulation of lipid metabolism, related target identification and drug discovery
3)Cancer therapy, focused on deubiquitination of oncogene proteins and related target identification and drug discovery.

top publication

1. Jin-Zheng Wang, Jin Zhou, Chang Xu, Hongbin Sun*, László Kürti* and Qing-Long Xu.* Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives. J. Am. Chem. Soc. 2016, 138, 5202–5205. (IF 12.113 )

2. Zhuang Song, Yizhou Wu, Tao Xin, Xiaoan Wen, Hongbin Sun,* and Qing-Long Xu.* Rh(II)-Catalyzed Formal N-S Bond Insertion Reaction of Aryldiazoacetates into N-Phenyl-Sulfenyl Phthalimide. Chemical Communications 2016, 52, 6079-6082 (IF 6.834 )

3. Ming Yang, Xiaowen Yang, Hongbin Sun, Ang Li*. Total Synthesis of Ileabethoxazole, Pseudopteroxazole, and seco-Pseudopteroxazole. Angewandte Chemie International Edition 2016, 55, 2851-2855. (IF 11.261)

4. Xiantao Lei, Hong-Yan Xie, Chang Xu, Xiaoyu Liu, Xiaoan Wen, Hongbin Sun*, Qing-Long Xu*. Dearomatization of Indoles Derivatives via Pd-Catalyzed C-H Bond Functionalization of Pyrroles: Convenient Construction of Spiroindolenines. Advanced Synthesis & Catalysis 2016, 10.1002/adsc.201600135 (Very Important Publication). (IF 5.663)

5. Jinzheng Wang, Xiaoan Wen, Jun Liu*, Hongbin Sun.* Inhibition of Mitochondrial Biogenesis as a Potential Approach to Cancer Therapy. Recent Patents on Anti-Cancer Drug Discovery 2016, in press. (IF 4.295)

6. Chao Lin, XIaoan Wen,* Hongbin Sun.* Oleanolic acid derivatives for pharmaceutical use: a patent review. Expert Opinion On Therapeutic Patents 2016, in press. (IF 4.297)

7. Chen, F; Dong, RR; Zhong, KL; Ghosh, A ; Tang, SS; Long, Y; Hu, M; Miao, MX; Liao, JM; Sun, HB; Kong, LY; Hong, H*. Antidiabetic drugs restore abnormal transport of amyloid-beta across the blood-brain barrier and memory impairment in db/db mice. Neuropharmacology 2016, 101,123-136. (IF 5.106)

8. Wang, H; Chen, F; Zhong, KL; Tang, SS; Hu, M; Long, Y; Miao, MX ; Liao, JM; Sun, HB; Hong, H*. PPAR agonists regulate bidirectional transport of amyloid-beta across the blood-brain barrier and hippocampus plasticity in db/db mice. British Journal of Pharmacology 2016, 173, 372-385. (IF 4.842)

9. Li, QM; Luo, JG; Zhao, HJ ; Yu, WY; Wang, XB; Yang, MH ; Luo, J ; Sun, HB; Chen, YJ; Guo, QL; Kong LY.* Involudispirones A and B: Sesterterpenes Containing a Dispiro Ring from Stahlianthus involucratus. Asian Journal of Organic Chemistry 2015, 4, 1366-1369. (IF 3.318)

10. Chao Lin, Le Zhen, Yong Cheng, Hong-Jin Du, Hui Zhao, Xiaoan Wen, Lingyi Kong, Qing-Long Xu*, Hongbin Sun*. Visible-light Induced Isoindoles Formation to Trigger Intermocular Diels-Alder Reactions In the Presence of Air. Organic letters 2015, 17, 2684–2687. (IF 6.364)

11. Xueli Zhang, Yanli Tian, Can Zhang, Xiaoyu Tian, Alana W. Ross, Robert D. Moir, Hongbin Sun, Rudolph E. Tanzi, Anna Moore, Chongzhao Ran*. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease. PNAS 2015, 112 (31) 9734-9739. (IF 9.674)

12. Xueli Zhang, Yanli Tian, Hongbin Zhang, Amol Kavishwar, Matthew Lynes, Anna-Liisa Brownell, Yu-Hua Tseng, Hongbin Sun, Anna Moore, Chongzhao Ran*. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Scientific Reports 2015, DOI: 10.1038/srep13116. (IF 5.578)

13. Qiong Sun, Zisheng Kang, Lingjing Xue, Yunkai Shang, Zhigui Su, Hongbin Sun, Qineng Ping, Ran Mo,*Can Zhang.* A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery. J. Am. Chem. Soc. 2015, 137, 6000-6010. (IF 12.113 )

14. Xiaowei Sun, Xiaoan Wen, Yan-yan Chen, Chen Shi, Chengzhe Gao, Yong Wu, Li-jun Wang, Xiu-hong Yang*, Hongbin Sun*. Discovery of highly potent renin inhibitors potentially interacting with the S3′subsite of renin. European Journal of Medicinal Chemistry 2015, 103, 269-288. (IF 3.447)

15. Jiaqi Shan, Hongbin Sun.* The discovery and development of Prasugrel. Expert Opinion on Drug Discovery 2013, 8, 897-905. (IF 3.539)

16. Xueli Zhang, Yanli Tian, Zeng Li, Xiaoyu Tian, Hongbin Sun, Hong Liu, Anna Moore, Chongzhao Ran*. Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid Beta species in Alzheimer's disease. J. Am. Chem. Soc. 2013, 135, 16397-409. (IF 12.113 )

17. Jiaqi Shan, Boyu Zhang, Yaoqiu Zhu, Bo Jiao, Weiyi Zheng, Xiaowei Qi, Yanchun Gong, Fang Yuan, Fusheng Lv, Hongbin Sun.* Overcoming Clopidogrel Resistance: Discovery of Vicagrel as a Highly Potent and Orally Bioavailable Antiplatelet agent. Journal of Medicinal Chemistry 2012, 55, 3342–3352. (IF 5.447)

18. Xiaoan Wen, Hongbin Sun,* Jun Liu, Keguang Cheng, Pu Zhang, Liying Zhang, Jia Hao, Luyong Zhang, Peizhou Ni, Spyros E. Zographos, Demetres D. Leonidas, Kyra-Melinda Alexacou, Thanasis Gimisis, Joseph M. Hayes, Nikos G. Oikonomakos. Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure-Activity Relationships and X-ray Crystallographic Studies. Journal of Medicinal Chemistry 2008, 51, 3540-3554. (IF 5.447)

19. Jizhe Dong, Yanchun Gong, Jun Liu, Xiangfeng Chen, Xiaoan Wen,* Hongbin Sun.* Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin. Bioorganic & Medicinal Chemistry 2014, 22, 1383-1393. (IF 2.793)

20. Su-Yi Li, Xiao-Bing Wang, Sai-Sai Xie, Neng Jiang, Kelvin D.G.Wang, He-Quan Yao, Hongbin Sun, Ling-Yi Kong.* Multifunctional tacrineeflavonoid hybrids with cholinergic, -amyloid-reducing, and metal chelating properties for the treatment of Alzheimer’s disease. European Journal of Medicinal Chemistry 2013, 69, 632-646. (IF 3.447)

21. Xue Wang, Yupeng Chen, Daoud Abdelkader, Waseem Hassan, Hongbin Sun, Jun Liu.* Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes. Journal of Diabetes Research 2015, DOI: 10.1155/2015/973287. (IF 2.164)

22. Qian, Yisong ; Huang, Menghao; Guan, Teng; Chen, Lan; Cao, Liangxun; Han, Xiao-Jian; Huang, Longfei ; Tang, Xuzhen ; Li, Yunman; Sun, Hongbin. Maslinic acid promotes synaptogenesis and axon growth via Akt/GSK-3 beta activation in cerebral ischemia model. European Journal of Pharmacology 2015, 764, 298-305. (IF 2.532)

23. Zengwei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen,* Hongbin Sun.* Discovery of Highly Potent DPP-4 Inhibitors by Hybrid Compound Design Based on Linagliptin and Alogliptin. European Journal of Medicinal Chemistry 2014, 83, 547-560. (IF 3.447)

24. Bo Gui, Fuzhou Hua, Jie Chen, Zeping Xu, Hongbin Sun and Yanning Qian.* Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3K/Akt Pathway. Mediators of Inflammation 2014, DOI: 10.1155/2014/451826. (IF 3.236)

25. Jia Hao, Jun Liu, Xiaoan Wen, Hongbin Sun.* Synthesis and cytotoxicity evaluation of oleanolic acid derivatives. Bioorganic & Medicinal Chemistry Letters 2013, 23, 2074-2077. (IF 2.420)