Serafim  Papadimitriou

Fulvio Magni



Fulvio Magni currently holds the position of Professor in the Department of Medicine and Surgery, University Milano Bicocca.he worked has Researcher at the Mass Spectrometry Laboratory of the IRCCS S. Raffaele of Milan, Italy 2002 Associate Professor at the University of Milano-Bicocca.He received his Ph.D. degree in Pharmacology and Toxicology.In the last years he has been activated several lines of activity in the Clinical Proteomics field aimed to search biomarkers in solid (tissues and cellular cultures) and fluid biological samples by mass spectrommetry. In collaboration with clinical units (urologist and anatomo-pathologist) and with life science units (biochemist and clinical biochemist) he has begun a wide project aimed to define the proteome of the normal and of the renal cell carcinoma (RCC) and of subcellular fractions. Today he has extended his activity to study the proteome of biological fluids (serum, plasma, urine and amniotic liquor) to search possible biomarkers in several pathologies: renal cell carcinoma, diabetic nephropathy, and preterm premature rupture of membranes.Very recently he has started the application of the “imaging by mass spectrometry” techniques to investigate the spatial distribution of proteins analyzing directly the tissues. He is applying this new technology to study the thyroid tumor and the chronic kidney disease


Area of Interest

1.Clinical Chemistry.
2.Kinetics and metabolism of endogenous compounds using stable isotope labelled tracers in humans.

top publication

1. Ornellas P, Ornellas AA, Chinello C, Gianazza E, Mainini V, Cazzaniga M, Pereira DA, Sandim V, Cypriano AS, Koifman L, da Silva PC, Alves G, Magni F. Downregulation of C3 and C4A/B complement factor fragments in plasma from patients with squamous cell carcinoma of the penis. IntBraz J Urol. 2012 Nov;38(6):739-49.

2. Mainini V, Bovo G, Chinello C, Gianazza E, Grasso M, Cattoretti G, Magni F. Detection of high molecular weight proteins by MALDI imaging mass spectrometry. MolBiosyst. 2013 2013; 9(6): 1101-7

3. Magni F, Lalowski M, Mainini V, Marchetti-Deschmann M, Chinello C, Urbani A, Baumann M. Proteomics imaging and the kidney. J Nephrol. 2013 May 16;26(3):430-6

4. Raimondo F, Corbetta S, Morosi L, Chinello C, Gianazza E, Castoldi G, Di Gioia C, Bombardi C, Stella A, Battaglia C, Bianchi C, Magni F, Pitto M. Urinaryexosomes and diabeticnephropathy: a proteomicapproach. MolBiosyst. 2013; 9(6): 1139-46.

5. Raimondo F, Morosi L, Corbetta S, Chinello C, Brambilla P, Della Mina P, Villa A, Albo G, Battaglia C, Bosari S, Magni F, Pitto M Differentialproteinprofiling of renalcell carcinoma urinaryexosomes. MolBiosyst. 2013; 9(6):1220-336. Lalowski M, Magni F, Mainini V, Monogioudi E, Gotsopoulos A, Soliymani R, Chinello C, Baumann M. Imaging mass spectrometry: a new tool for kidney disease investigations.NephrolDialTransplant. 2013 Jul;28(7):1648-56.

7. Urbani A, De Canio M, Palmieri F, Sechi S, Bini L, Castagnola M, Fasano M, Modesti A, Roncada P, Timperio AM, Bonizzi L, Brunori M, Cutruzzolà F, De Pinto V, Di Ilio C, Federici G, Folli F, Foti S, Gelfi C, Lauro D, Lucacchini A, Magni F, Messana I, Pandolfi PP, Papa S, Pucci P, Sacchetta P,The mitochondrial Italian Human Proteome Project initiative (mt-HPP). The Italian Mt-Hpp Study Group-Italian Proteomics Association. MolBiosyst. 2013 Aug 2;9(8):1984-92.

8. Mainini V, Pagni F, Garancini M, Giardini V, De Sio G, Cusi C, Arosio C, Roversi G, Chinello C, Caria P, Vanni R, Magni F. An Alternative Approach in Endocrine Pathology Research: MALDI-IMS in PapillaryThyroid Carcinoma. EndocrPathol. 2013 Dec;24(4):250-3. doi: 10.1007/s12022-013-9273-8.

9. Consonni S, Mainini V, Pizzardi A, Gianazza E, Chinello C, Locatelli A, Magni F. Non-invasively collected amniotic fluid as a source of possible biomarkers for premature rupture of membranes investigated by proteomic approach.Archives of Gynecology and Obstetrics2014 Feb;289(2):299-306.

10. Mainini V, Pagni F, Ferrario F, Pieruzzi F, Grasso M, Stella A, Cattoretti G, Magni F. MALDI imaging mass spectrometry in glomerulonephritis: feasibility test. Histopathology. 2013 Histopathology. 2014 May;64(6):901-6

11. Raimondo F, Corbetta S, Chinello C, Pitto M, Magni F. The urinary proteome and peptidome of renal cell carcinoma patients: a comparison of different techniques. Expert Rev Proteomics. 2014 Aug;11(4):503-14.

12. Chinello C, Cazzaniga M, De Sio G, Smith AJ, Gianazza E, Grasso A, Rocco F, Signorini S, Grasso M, Bosari S, Zoppis I, Dakna M, van der Burgt YE, Mauri G, Magni F. Urinary signatures of renal cell carcinoma investigated by peptidomic approaches. PLoS One. 2014 Sep 9;9(9):e106684. doi: 10.1371/journal.pone.0106684.

13. De Sio G, Smith AJ, Galli M, Garancini M, Chinello C, Bono F, Pagni F, Magni F. A MALDI-Mass Spectrometry Imaging method applicable to different formalin-fixed paraffin-embedded human tissues. MolBiosyst. 2015 Jun;11(6):1507-14.

14. Liu X, Chinello C, Musante L, Cazzaniga M, Tataruch D, Calzaferri G, James Smith A, De Sio G, Magni F, Zou H, Holthofer H. Intraluminal proteome and peptidome of human urinary extracellular vesicles.ProteomicsClin Appl. Proteomics Clin Appl. 2015 Jun;9(5-6):568-73

15. Pagni F, Mainini V, Garancini M, Bono F, Vanzati A, Giardini V, Scardilli M, Goffredo P, Smith AJ, Galli M, De Sio G, Magni F. Proteomics for the diagnosis of thyroid lesions: preliminary report Cytopathology. 2015 Oct;26(5):318-24

16. Mainini V, Lalowski M, Gotsopoulos A, Bitsika V, Baumann M, Magni F. MALDI-imaging mass spectrometry on tissues. Methods Mol Biol. 2015; Methods Mol Biol. 2015;1243:139-64.

17. Raimondo F, Corbetta S, Savoia A, Chinello C, Cazzaniga M, Rocco F, Bosari S, Grasso M, Bovo G, Magni F, Pitto M. Comparative membrane proteomics: a technical advancement in the search of renal cell carcinoma biomarkers.MolBiosyst. 2015 Jun;11(6):1708-16.

18. Pagni F, L'Imperio V, Bono F, Garancini M, Roversi G, De Sio G, Galli M, Smith AJ, Chinello C, Magni F. Proteome analysis in thyroidpathology. Expert Rev Proteomics. 2015 Aug;12(4):375-90. doi: 10.1586/14789450.2015.1062369.

19. Chinello C, Cazzaniga M, De Sio G, Smith AJ, Grasso A, Rocco B, Signorini S, Grasso M, Bosari S, Zoppis I, Mauri G, Magni F. Tumorsize, stage and grade alterations of urinarypeptidome in RCC. J Transl Med. 2015 Oct 20;13(1):332.

20. L'Imperio V, Smith A, Chinello C, Pagni F, Magni F. Proteomics and glomerulonephritis: A complementary approach in renal pathology for the identification of chronic kidney disease-related markers. Proteomics ClinAppl 2016 Apr;10(4):371-83. doi: 10.1002/prca.201500075.

21. Smith A, L'Imperio V, De Sio G, Ferrario F, Scalia C, Dell'Antonio G, Pieruzzi F, Pontillo C, Filip S, Markoska K, Granata A, Spasovski G, Jankowski J, Capasso G, Pagni F, Magni F. α-1-antitrypsin detected by MALDI-Imaging in the study of glomerulonephritis: its relevance in chronic kidney disease progression. Proteomics. 2016 Jan 7. doi: 10.1002/pmic.201500411. [Epub ahead of print]

22. Pagni F, De Sio G, Garancini M, Scardilli M, Chinello C, Smith AJ, Bono F, Leni D, Magni F. Proteomics in thyroid cytopathology: relevance of MALDI-Imaging in distinguishing malignant from benign lesions. Proteomics. 2016 Mar 31. doi: 10.1002/pmic.201500448.

23. Raimondo F, Cerra D, Magni F, Pitto M. Urinary proteomics for the study of genetic kidney diseases. Expert Rev Proteomics. 2016 Mar;13(3):309-24.

24. Manuel Galli,Italo Zoppis,Gabriele De Sio,Clizia Chinello,Fabio Pagni,Fulvio Magni,and Giancarlo Mauri. A Support Vector Machine Classification of Thyroid Bioptic Specimens Using MALDI-MSI Data. Advances in Bioinformatics Volume 2016 (2016), Article ID 3791214, 7 pages