Serafim  Papadimitriou


Associate Professor


He graduated in 1989 with a B.Sc. (Special Chemistry) degree; then later on October 1990, he pursued his graduate career with Prof. Tara P. Dasgupta, and acquired a Ph.D. degree in inorganic chemistry in May 1994. Currently, he is an Associate Professor in Chemistry in the Department of Chemistry and Chemistry at Old Dominion University. Previously he was an Assistant Professor in Chemistry at The University of Southern Mississippi (USM) from August 21, 2006 until August 12, 2013, and before that, he was also faculty member at The University of the West Indies, Cave Hill Campus from 1994-2003. He was a postdoctoral fellow at ExxonMobil Research and Engineering Company, Virginia Tech, The Ohio State University, and Colorado State University. He has published more than 60 articles, two textbooks, and five book chapters; directed three postdoctoral fellows, and directed six graduate students at USM and U.W.I.


Area of Interest

My area of research revolves around biological and inorganic chemistry, bioinorganic and inorganic reaction mechanisms, which includes the following:
Synthesis and characterization of supramolecular polypyridyl osmium(II), palladium(II), platinum(II), ruthenium(II), vanadium(IV), and vanadium(V) complexes for bioinorganic studies of DNA recognition and reactions by metallointercalators, followed by their uses as anti-cancer agents in photodynamic therapy; also the synthesis, characterization, and anti-cancer studies of cobalt(III)-, copper(II)-, and gallium(III)-containing complexes with natural products-derived thiosemicarbazones as ligands.
• The synthesis, characterization, and biomedical uses of cobalt, copper, vanadium, and zinc complexes in alleviating diabetes.
• The synthesis, characterization, reactivity, and biomedical uses of NOx-containing compounds.
• Synthesis and characterization of novel non-hydrolyzable nucleotides (inclusive of C-13 labeled nucleotides); also cobalt(III), chromium(III) and vanadium(IV/V) complexes. Their uses as inhibitors of the enzymatic synthesis of DNA through the use of DNA polymerase
• The synthesis, characterization, and use of mixed-metal binuclear photocatalysts for the production of H2 and O2 from water (artificial photosynthesis) with the use of photocatalysts that contain polyoxometallates and ruthenium(II) and cobalt(II)/cobalt(III) metal centers. Multinuclear NMR (11B, 19F, 31P, and 59Co, to name a few), EPR, cyclic voltammetry, electron transfer reactions in aqueous media are used to characterize species in solution. In essence we are embarking on the use of nanoparticles to make renewable energy. There is an interest in photochemistry, and the use of X-rays to map out metal centers in solution, and Raman spectroscopy.
• Metallomesogens: Design and synthesis of metallomesogens for CO2 sequestering and production of biodegradable polymers.
• The use of EPR {V(IV), Co(II), Cu(II), and Mo(V) at ambient and liquid nitrogen temperatures}, NMR (1H, 11B, 13C, 15N, 19F, 31P, 49Ti, 51V, 59Co, 95Mo, 119Sn, and 195Pt), and other physical means in the structural elucidation of various transition metal complexes.
• The synthesis, characterization, reactivity, and biomedical uses of metallomesogens.

top publication

1. Beckford, Floyd A.; Stott, Alyssa; Mbarushimana, P. Canisius; LeBlanc, Marc-Andre; Hall, Kinsey; Smith, Samantha; Bullock, Jimmie L.; Houghton, Dennis J.; Holder, Alvin A.; Gerasimchuk, Nikolay; Gonzalez-Sarrías, Antonio; Seeram, Navindra P. “Anticancer, biophysical and computational investigations of half-sandwich ruthenium(II) thiosemicarbazone complexes: The effect of arene versus thiacrown face-cap.” Interdiscip. J. Chem., 2016, DOI: 10.15761/IJC.1000101.
2. A preface: Holder, Alvin A. “How Virginia Tech placed me on the map from May 2002 to June 2003! A bridge to my future.” Inorg. Chim. Acta 2016, DOI: 10.1016/j.ica.2016.07.012. 65. Celestine, Michael J.; Joseph, Lorne S.; Holder, Alvin A. “Kinetics and mechanism of the oxidation of a cobaloxime by sodium hypochlorite in aqueous solution: Is it an outer-sphere mechanism?” Inorg. Chim. Acta 2016, DOI: 10.1016/j.ica.2016.07.013.
3. Lawrence, Mark A. W.; Celestine, Michael J.; Artis, Edward T.; Joseph, Lorne S.; Esquivel, Deisy L.; Ledbetter, Abram J.; Cropek, Donald M.; Jarrett, William L.; Bayse, Craig A.; Brewer, Matthew I.; Holder, Alvin A. “Computational, Electrochemical, and Spectroscopic Studies of two Mononuclear Cobaloximes: The influence of an axial pyridine and solvent on the redox behaviour and evidence for pyridine coordination to cobalt(I) and cobalt(II) metal centres.” Dalton Trans. 2016, 45, 10326-10342.
4. Dutta, Shovan; Huddleston, Alexis; Arca, Jessa Faye; Mitra, Amlan; Heller, Loree; Ledizet, Michel; Anderson, John F.; Neelakanta, Girish; Holder, Alvin A.; Sultana, Hameeda “Mosquito repelling citral-based compounds and complexes with Cu(II) and Co(III) metal centers enhances dengue virus infection in human keratinocytes.” PLoS Neglected Tropical Diseases (open Access) 2016. Submitted.
5. Williams, Jennie L.; Lewis-Alleyne, Lesley C.; Solomon, Melinda; Nguyen, Long; Johnson, Robert; Vital, Jennifer; Ji, Ping; Durant, John; Cooper, Camille; Cagle, Patrice; Martin, Patrick; VanDerveer, Don; Jarrett, William L.; Holder, Alvin A. “An in vitro study on the effect of synthesized tin(IV) complexes on glioblastoma, colorectal, and skin cancer cell lines.” Biomed. Res. Clin. Pract. 2016, DOI: 10.15761/BRCP.1000103.
6. Boodram, Shivani; Bullock, Jimmie L.; Rambaran, Varma H.; Holder, Alvin A. “The Use of Inorganic Compounds for the Photodynamic Treatment of Cancer and Microbial Infections.” Recent Pat. Nanotechnol. 2016. Accepted for publication.
7. Hussain, Kashif Ijaz; Usman, Muhammad; Siddiq, Mohammad; Rasool, Nasir; Nazar, Muhammad Faizan; Ahmad, Iqbal; Holder, Alvin A.; Altaf, Ataf Ali “Application of micellar enhanced ultra-filtration for the removal of sunset yellow dye from aqueous media.” J. Dispers. Sci. Technol. 2016, DOI: 10.1080/01932691.2016.1146616.
8. Sandhaus, Shayna; Taylor, Rosella; Edwards, Tiffany; Huddleston, Alexis; Wooten, Ykeysha; Venkatraman, Ramaiyer; Weber, Ralph T.; González-Sarrías, Antonio; Martin, Patrick M.; Cagle, Patrice; Tse-Dinh, Yuk-Ching; Beebe, Stephen J.; Seeram, Navindra; Holder, Alvin A. “A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.” Inorg. Chem. Commun. 2016, 64, 45-49.
9. Lawrence, Mark A.W.; Holder, Alvin A. “Assessing the stability of the Co(I) species of two mononuclear dichlorocobalt(II) compounds bearing 2,2’-bipyridine and trans-2-(2'-quiolyl)methylene-3-quinuclidione ligands via 59Co NMR spectroscopy, electrochemical, and catalyzed proton electroreduction studies.” Inorg. Chim. Acta 2016, 441, 157-168. 57. Abzianidze, Victoria V.; Prokofieva, Daria S.; Chisty, Leonid A.; Bolshakova, Ksenia P.; Berestetskiy, Alexander O.; Panikorovskii, Taras L.; Bogachenkov, Alexander S.; Holder, Alvin A. “Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.” Bioorg. Med. Chem. Lett. 2015, 25, 5566-5569.
10. Lawrence, Mark A. W.; McMillen, Colin D.; Gurung, Raj K.; Celestine, Michael J.; Arca, Jessa F.; Holder, Alvin A. "Synthesis, X-ray crystallographic, electrochemical, and spectroscopic studies of bis-(1,10-phenanthroline)(2,2’-bipyridine)cobalt(III) hexafluorophosphate." J. Chem. Crystallogr. 2015, 45(8), 427-433.
11. Ingram, Conrad W.; Kybakaya, Geoffrey; Bacsa, John; Mathis, Stephan; Holder, Alvin A.; Rambaran, Varma H.; Dennis, Brandon; Castaneda, Esmeralda “Complex three-dimensional lanthanide metal-organic frameworks with variable coordination spheres based on pyrazine-2,3,5,6-tetracarboxylate.” CrystEngComm 2015, 17, 5377-5388.
12. Celestine, Michael J.; Bullock, Jimmie L.; Boodram, Shivani; Rambaran, Varma H.; Holder, Alvin A. "Interesting properties of p-, d-, and f-block elements when coordinated with dipicolinic acid and its derivatives as ligands: their use as inorganic pharmaceuticals.” Rev. Inorg. Chem. 2015, 35(2), 57-67.
13. Kumar, Kewal; Schniper, Sarah; González-Sarrías, Antonio; Holder, Alvin A.; Sanders, Natalie; Sullivan, David; Jarrett, William L.; Davis, Krystyn; Bai, Fengwei; Seeram, Navindra P.; Kumar, Vipan "Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: Synthesis, cytotoxic and antimalarial evaluation." Eur. J. Med. Chem. 2014, 86, 81-86.
14. Yuan, Hao; Newton, De'Andra L.; Seymour, Luke A.; Metz, Anja; Cropek, Donald; Holder, Alvin A.; Ofoli, Robert Y. “Characterization and functional assessment of a cobalt(III)-oxo cubane cluster water oxidation catalyst immobilized on ITO.” Catal. Commun. 2014. 56, 76-80.
15. Horton, Dorothy C.; VanDerveer, Don; Krzystek, Jurek; Telser, Joshua; Pittman, Thomas; Crans, Debbie C.; Holder, Alvin A. “Spectroscopic Characterization of L-ascorbic Acid-induced Reduction of Vanadium(V) Dipicolinates: Formation of V(III) and V(IV) Complexes from V(V) Dipicolinate Derivatives.” Inorg. Chim. Acta. 2014, 420, 112-119.
16. Rambaran, Varma H.; Erves, Travis R.; Grover, Kristy; Balof, Shawna; Moody, LaMaryet V.; Ramsdale, Stuart E.; Seymour, Luke A.; VanDerveer, Don; Cropek, Donald M.; Weber, Ralph T.; Holder, Alvin A. “A Comparison of the Self Assembled Frameworks of Three Cobalt(II) Coordination Compounds Bearing Dipicolinic Acid and Chelidamic Acid Ligands” J. Chem. Cryst. 2013, 43, 509-516.
17. Holder, Alvin A.; Taylor, Patrick; Magnusen, Anthony R.; Moffett, Erick T.; Meyer, Kyle; Hong, Yiling; Ramsdale, Stuart E.; Gordon, Michelle; Stubbs, Javelyn; Seymour, Luke A.; Acharya, Dhiraj; Weber, Ralph T.; Smith, Paul F.; Dismukes, G. Charles; Ji, Ping; Menocal, Laura; Bai, Fengwei; Williams, Jennie L.; Cropek, Donald M.; Jarrett William L. “Synthesis, characterisation, and preliminary photodynamic therapeutic in vitro studies of mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes.” Dalton Trans. 2013, 42, 11881-11899.
18. Holder, Alvin A. “Inorganic Pharmaceuticals.” Annu. Rep. Prog. Chem., Sect. A 2013, 109, 317-339.
19. Holder, Alvin A. “Chromium, molybdenum, and tungsten.” Annu. Rep. Prog. Chem., Sect. A 2013, 109, 119-130.
20. Cropek, Donald M.; Metz, Anja; Müller, Astrid M.; Gray, Harry B.; Horne, Toyketa; Horton, Dorothy C.; Poluektov, Oleg; Tiede, David M.; Weber, Ralph T.; Jarrett, William L.; Phillips, Joshua D.; Holder, Alvin A. “A novel ruthenium(II)-cobaloxime supramolecular complex for photocatalytic H2 evolution: Synthesis, characterisation, and mechanistic studies.” Dalton Trans. 2012, 41(42), 13060-13073.
21. Holder, Alvin A. “Chromium, molybdenum and tungsten.” Annu. Rep. Prog. Chem., Sect. A 2012, 108, 166-175.
22. Holder, Alvin A. “Inorganic Pharmaceuticals.” Annu. Rep. Prog. Chem., Sect. A 2012, 108, 350-358.
23. Beckford, Floyd A; Thessing, Jeffrey; Stott, Alyssa; Holder, Alvin A.; Poluektov, Oleg G.; Li, Liya; Seeram, Navindra P. “Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothio-amides.” Inorg. Chem. Commun. 2012, 15, 225-229.
24. Lewis, Nerissa A.; Liu, Fange; Seymour, Luke; Magnusen, Anthony; Erves, Travis R.; Arca, Jessa Faye; Beckford, Floyd A.; Venkatraman, Ramaiyer; González-Sarrías, Antonio; Fronczek, Frank R.; VanDerveer, Don G.; Seeram, Navindra P.; Liu, Aimin; Jarrett, William L.; Holder, Alvin A. “Synthesis, characterization and preliminary in vitro studies of vanadium(IV) complexes with a Schiff base and thiosemicarbazones as mixed-ligands.” Eur. J. Inorg. Chem. 2012, 2012, 664-677.
25. Holder, Alvin A. “Chromium, molybdenum and tungsten.” Annu. Rep. Prog. Chem., Sect. A 2011, 107, 163–172.
26. Holder, Alvin A. “Inorganic Pharmaceuticals.” Annu. Rep. Prog. Chem., Sect. A 2011, 107, 359–378.