Serafim  Papadimitriou

Jian-Hui Xiao




Area of Interest

1. Application evaluation of higher fungi resource involving the bioactivity such as immunomodulatory, antibiotic, antitumor, antioxidant of metabolites.
2. Fermentation regulation and signal transduction of fungal secondary metabolite, Isolation, purification and identification of valuable metabolite.
3. Relation of time series on both valuable metabolite and morphogenesis in higher fungi; Molecular mechanism of the fruit body formation by Cordyceps spp.
4. Biotranformation of traditional Chinese medicine
5. Natural inducer screening of proliferation, differentiation of stem cell, and its mechanism 6. Biology of Stem cell

top publication

Liu RM, Sun RG, Zhang LT, Zhang QF, Chen DX, Zhong JJ, Xiao JH*. Hyaluronic acid enhances proliferation of human amniotic mesenchymal stem cells through activation of Wnt/β-catenin signaling. Experimental Cell Research.2016, 345(2):218-229.
Xiao DM, Yu S, Xiao JH*. Antioxidant activities of alkali-soluble polysaccharides from medicinal mushroom Cordyceps taii and its chemical characteristics. Biomedical Research 2016, 27(1):199-206.
Qin H, Xu JW, Xiao JH, Tang YJ, Xiao H, Zhong JJ. Cell factories of higher fungi for useful metabolite production. Advances in Biochemical Engineering/Biotechnology 2016, 155:199-235.
Liu YY, Zhong JJ, Xiao JH*. An UPLC-MS/MS method for highly selective and sensitive determination of jiangxienone with potent antitumor activity from Cordyceps jiangxiensis. Latin American Journal of Pharmacy 2016, 35(2):265-273
Liu RM, Li YB, Liang XF, Liu HZ, Xiao JH*, Zhong JJ. Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: involvement of oxidative stress and antioxidant protective system. Chemico-Biological Interactions 2015, 240:134-144.
Liu RM, Zhang XJ, Liang GY, Yang YF, Zhong JJ, Xiao JH*.Antitumor and antimetastatic activities of chloroform extract of medicinal mushroom Cordyceps taii in mouse models. BMC Complementary and Alternative Medicine 2015, 15:216.
Li XG, Pan WD, Luo HY, Liu RU, Xiao JH*, Zhong JJ. New cytochalasins from medicinal marcofungus Cordyceps taii and their inhibitory activities against human cancer cells. Bioorganic & Medicinal Chemistry Letters 2015, 25(9):1823-26
Liu RM, Zhang XJ, Li XF, Xiao JH*, Zhong JJ. Simple and rapid method for simultaneous determination of eleven nucleosides and nucleobases in medicinal macrofungus Cordcyeps taii. Latin American Journal of Pharmacy 2015,34 (2): 283-90.
Lü YH, Pan WD, Xiao JH*, Sun ZH, Zhong JJ. Cytotoxic mechanism of novel compound jiangxienone from Cordyceps jiangxiensis against cancer cells involving DNA damage response pathway. Process Biochemistry 2014; 49(4):697-705.
Dou Y, Xiao JH*, Xia XX, Zhong JJ. Effect of oxygen supply on biomass and helvolic acid production in submerged fermentation of Cordyceps taii. Biochemical Engineering Journal 2013, 81(1):73-9.
Xiao JH*, Qi Ying, Xiong Q. Nucleosides, a valuable chemical marker for quality control in traditional Chinese medicine Cordyceps. Recent Patents on Biotechnology 2013, 7(1):153-166.
Xiao JH*, Xiao DM, Chen DX, Xiao Y, Liang ZQ, Zhong JJ. Polysaccharides from the medicinal mushroom Cordyceps taii show antioxidant and immunoenhancing activities in a D-galactose-induced aging mouse model. Evidence-Based Complementary and Alternative Medicine vol. 2012, Article ID 273435, 15 pages.
Xiao JH*, Sun ZH, Pan WD, Lü YH, Chen DX, Zhong JJ. Jiangxienone, a new compound with potent cytotoxicity against tumor cells from traditional Chinese medicinal mushroom Cordyceps jiangxiensis. Chemistry & Biodiversity 2012, 9(7):1349-1355.
Xiao JH*, Sun ZH, Zhang XJ, Xiong Q, Zhong JJ. Efficient extraction and rapid quantitative determination of nucleoside compounds from Cordyceps jiangxiensis, a new Cordyceps producing-cordycepin. Latin American Journal of Pharmacy 2012,31 (8): 1161-9.
Xiao JH*, Xiao DM, Sun ZH, Xiao Y, Zhong JJ. (2011) Antioxidative potential of polysaccharide fractions produced from traditional Chinese medicinal macrofungus Cordyceps jiangxiensis in vitro. African Journal of Biotechnology 10 (34):6606-6615.
Xiao JH*, Xiao DM, Xiong Q, Liang ZQ, Zhong JJ. (2010) Nutritional requirements for the hyperproduction of bioactive exopolysaccharides by submerged fermentation of the edible medicinal fungus Cordyceps taii. Biochemical Engineering Journal. 49:241-249.