Serafim  Papadimitriou

Amit K. Tiwari

Assistant Professor


Dr. Tiwari is an Assistant Professor in the College of Pharmacy and Pharmaceutical Sciences, University of Toledo. By using genomic analysis and pharmacokinetic/pharmacodynamics approaches, Dr. Tiwari intends to probe molecular and signaling pathways at the systems-level and build quantitative models to translate these findings in improving and developing new and safer anticancer drugs. Additionally, Dr. Tiwari’s work has established novel ways to reverse drug resistance and to improve cancer chemotherapeutics. Dr. Tiwari has authored over 40 peer-reviewed articles. He is an editor and editorial board member of number of journals and is an ad hoc reviewer of over 50 journals.


Area of Interest

Dr. Tiwari’s Cancer Pharmacology and Systems Therapeutics lab is focused to not only finding a cure for cancer but also on bridging Cancer Health Disparity among segments of the population. Currently, his lab’s efforts are directed in the following key areas:
Multidrug Resistance in Cancer
Targeting Factors Associated with Cancer Health Disparity
Drug Discovery & Experimental Therapeutics

top publication

1. Shi Z*, Tiwari AK*, Ashby CR, Fu LW and Chen ZS. Anticancer role of Phospodiesterase 5 inhibitors. The Research and Biology of Cancer I. ISBN: 978-1-477554-999. (*Joint-First Author).
2. Tiwari AK#, Yang DH, and Chen ZS. Molecular mechanisms of methotrexate resistance. Nova Science Publishers, Inc. ISBN – 978-1-62100-596-4, 2012
3. Mittal R, Agrawal A, Tourne M, Koduru SV, Viana AG, Reddy G, and Tiwari AK#. Nanoparticle-Based Therapeutics to Circumvent Cancer Chemoresistance. NanoBiomedicine: Nanostructured Drug Delivery. 2015, Vol. 4, Pages 383-408, Studium Press LLC, USA; ISBN: 1-62699-054-9, 2015
4. Koduru SV, Tiwari AK, and Ravnic DJ. Comprehensive analysis of non-coding small RNAs in human triple negative breast cancer. (Under review – BMC Genomics)
5. Koduru SV, Tiwari AK, Hazard SW, Mahajan M, Ravnic DJ. Comprehensive analysis of non-coding small RNAs in human colorectal cancer. (Under review – BMC Genomics)
6. Kirwen EM, Batra T, Karthikeyan C, Deora GS, Vathore V, Mulakayalae C, Mulakayala N, Nusbaum AC, Joel Chena, Amawi H, McIntosh K, Sahabjada, Arantes V, Shivnath N, Chaurasia D, Sharma N, Md Arshad , Trivedi P and Tiwari AK. 2,3-Diaryl-3Himidazo[ 4,5-b]pyridine derivatives as potential anticancer & anti-inflammatory agents. Acta Pharmaceutica Sinica B (Accepted April, 2016)
7. McIntosh K, Balch C and Tiwari AK#. Tackling multidrug resistance mediated by efflux transporters in tumor initiating cells. Expert Opinion in Drug Metabolism and Toxicity, (Accepted April, 2016)
8. Hussain S, Sulaiman A, Balch C, Chauhan H, Alhadidi Q and Tiwari AK#. Natural polyphenols in cancer chemoresistance. Nutrition and Cancer, (Accepted March 13, 2016)
9. Karthikeyan C, Malla R, Ashby CR Jr, Amawi H, Abbott KL, Moore J, Chen J, Balch C, Lee C, Flannery PC, Trivedi P, Faridi J, Pondugula SR, and Tiwari AK#. Pyrimido[1″,2″:1,5]pyrazolo[3,4-b]quinolines: Novel compounds that reverse ABCG2- mediated resistance in cancer cells. Cancer Lett. 2016 Mar 21. pii: S0304-3835(16)30180-X. doi: 10.1016/j.canlet.2016.03.030. [Epub ahead of print]; PMID: 27012188
10. Narayanan NK, Kunimasa K, Miller G, Tiwari AK and Narayanan B. Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon 26 tumor-bearing mouse model in vivo. 2015, Cancer Medicine (In press)
11. Malla R, Wang Y, Chan W, Tiwari AK, Faridi JS. Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways. Biochem Pharmacol. Amit K. Tiwari, Ph.D. C.V. P a g e 11 2015 Apr 27. pii: S0006-2952(15)00239-7. doi: 10.1016/j.bcp.2015.04.016. [Epub ahead of print] (Cited 7 times: as of 08-01-16)
12. Hassan H, Min BJ, Tiwari AK, Reddy GP, Hinton A, Adesiyun A and Abdela W. Antibacterial activity of plant extracts against food-borne pathogens and spoilage bacteria. International Journal of Poultry Science 14 (x): xx-xx, 2015
13. Malla R, Ashby CR, Narayanan N, Narayanan B, Faridi JS, and Tiwari AK#. Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer: Biochemical Biophysical Research Communications, May 20, 2015, In press (Cited 10 times: as of 08- 01-16)
14. Pondugula SR, Ferniany G, Ashraf F, Abbott KL, Smith BF, Coleman ES, Mansour M, Bird RC, Smith AN, Karthikeyan C, Trivedi P, Tiwari AK. Stearidonic acid, a plant-based dietary fatty acid, enhances the chemosensitivity of canine lymphoid tumor cells (In Press, Biochemical Biophysical Research Communications, March 2015) (Cited 2 times: as of 08-01-16)
15. Balaji NV, Ramani MV, Viana AG, Sanglard LP, White J, Mulabagal V, Lee C, Gana TJ, Egiebor NO, Subbaraju GV and Tiwari AK#. Design, Synthesis and In Vitro Cell-based Evaluation of the Anti-cancer Activities of Curcumin and Hispolon Analogs: (Bioorganic Medicinal Chemistry, March 2015)