Serafim  Papadimitriou

Amuzescu P Bogdan

Associate Professor


Bogdan P. Amuzescu, MD (1991), PhD (2003) for research in ion channel biophysical properties. Fellowships at Katholieke Universiteit Leuven (2000-2003). Currently associate professor in Dept. Biophysics & Physiology, Faculty of Biology, University of Bucharest. Managerial experience: advisory board member of the Romanian Society of Neuroscience (2004-2012), Romanian Society against Epilepsy (since 2015). Research of biophysical and pharmacological properties of ENaC/Deg and TRP channels, applied research in cardiac electrophysiology and cardiac safety drug testing. Several awards and honors, such as the First prize of Romanian Neuroscience Society, co-chair of a platform session on cardiac electrophysiology at the 53rd BPS meeting. He is serving as an editorial member of several reputed journals


Area of Interest

Mathematical modeling&analysis of complex biological systems (heart, neuronal networks)
Membrane biophysics and transport phenomena in biomembranes
Thermodynamics of biological systems
Molecular electrophysiology&pharmacology – the patch-clamp technique
Thermotransduction, nociception and pain
Molecular pathophysiology and experimental models of various diseases: inflammatory and neuropathic pain, diabetic neuropathy, neuronal and myocardial ischemia, Alzheimer’s disease.

top publication

1. Iacobas A.D., Amuzescu B., Ciontu Cristina (1990) : Procedeu de realizare a micropipetelor pentru culegerea curentilor ionici unicanal din biomembrane; Brevet RO-102203. Monitorul Oficial, Bucuresti.
2. Iacobas A.D., Amuzescu B., Ciontu Cristina (1990) : Aspecte energetice si informationale in studiile de bioelectrogeneza. in "Aspecte energetice si informationale in ecosisteme" (ed. Marioara Godeanu), A.O.S. Braila.
3. Iacobas A.D., Amuzescu B., Ciontu Cristina (1990) : Sistem de filtrare, detectie si prelucrare numerica a semnalelor canalelor ionice. in "Cibernetica aplicata", Ed. Acad., Bucuresti.
4. Reid G., Amuzescu B., Zech E., Flonta M.-L. (2001) : A system for applying rapid warming or cooling stimuli to cells during patch clamp recording or ion imaging. J. Neurosci. Methods 111(1):1-8. (24 citations)
5. Babes A., Amuzescu B., Krause U., Scholz A., Flonta M.-L., Reid G. (2002) : Cooling inhibits capsaicininduced currents in cultured rat dorsal root ganglion neurones. Neurosci. Lett.. 317(3):131-134. (30 citations)
6. Amuzescu B., Ion S., Popescu D., Movileanu L., Avram S., Macri B., Flonta M.-L. (2002) : Thermal group motion creates stochastic pores in plane phosphatidylcholine bilayers. Romanian J. Biophys. 12 (1-2): 37-52.
7. Pena F., Neaga E., Amuzescu B., Nitu A., Flonta M-L (2002) : Amitriptyline has a dual effect on the conductive properties of the epithelial Na channel. J Pharm. Pharmacol. 54:1393-1398. (4 citations)
8. Amuzescu B., Segal A., Flonta M-L., Simaels J., Van Driessche, W. (2003) : Zinc is a voltage-dependent blocker of native and heterologously expressed epithelial Na+ channels. Pflügers Arch. 446: 69-77. (6 citations)
9. Gwanyanya A., Amuzescu B., Zakharov S., Macianskiene R., Sipido K., Bolotina V., Vereecke J., Mubagwa K. (2004) : Magnesium-inhibited, TRPM6/7-like channel in cardiac myocytes: permeation of divalent cations and pHmediated regulation. J. Physiol., 559(3): 761-776. (37 citations)
10. Neaga E., Amuzescu B., Dinu C., Macri B., Pena F., Flonta M.-L. (2005) : Extracellular trypsin increases ASIC1a selectivity for monovalent versus divalent cations. J. Neurosci. Methods 144: 241-248. (8 citations)
11. Pena F., Amuzescu B., Neaga E., Flonta M.-L. (2006): Thermodynamic properties of hyperpolarizationactivated current (Ih) in a subgroup of primary sensory neurons, Exp. Brain Res., 173(2):282-290. (1 citation)
12. Marin A., Prica C., Amuzescu B., Neaga E., Flonta M.-L. (2008): ASIC1a activation by amitriptyline and FMRF-amide is removed by serine proteases, Channels 2(6):419-428. (2 citations)
13. Popescu D., Popescu A.G., Amuzescu B. (2010): Pulsatory liposomes – a possible biotechnological device for controlled drug delivery. I. The liposome swelling, Rom. J. Biophys. 20(1):37-46.
14. Popescu D., Popescu A.G., Amuzescu B., Maries E. (2010): Pulsatory liposomes – a possible biotechnological device for controlled drug delivery. II. The pore appearance, Rom. J. Biophys. 20(2):171-181.
15. Popescu A.G., Popescu D., Ion S., Amuzescu B. (2010): Pulsatory liposomes – a possible biotechnological device for controlled drug delivery. III. The liposome relaxation, Rom. J. Biophys. 20 20(3):223-234.
16. Bichir C.L., Georgescu A., Amuzescu B., Nistor G., Popescu M., Flonta M.-L., Corlan A.D., Svab I. (2011): Limit cycles by FEM for a one-parameter dynamical system associated to the Luo-Rudy I model, ROMAI J.6(2):27-39.
17. Corlan A.D., Amuzescu B., Milicin I., Iordachescu V., Poenaru E., Corlan I., De Ambroggi L. (2011): Intercellular conductance variability influences early repolarization potentials in a myocardial tissue model with stochastic architecture, Advanced Topics in Electrical Engineering (IEEE Proceedings, ISSN 2068-7966):1-4.
18. Chioncel V., Paun D., Amuzescu B., Sinescu C. (2012): Evolution features of hypertensive patients with primary aldosteronism – prospective study, J. Med. Life 5(3): 354-359.
19. Kusko M., Craciunoiu F., Amuzescu B., Halitzchi F., Selescu T., Radoi A., Popescu M., Simion M., Bragaru A., Ignat T. (2012): Design, fabrication and characterization of a low-impedance 3D electrode array system for neuro-electrophysiology, Sensors (Basel) 12(12):16571-16590.
20. Amuzescu B., Georgescu A., Nistor G., Popescu M., Svab I., Flonta M.-L., Corlan A. (2012): Stability and sustained oscillations in a ventricular cardiomyocyte model, Interdisciplinary Sciences: Computational Life Sciences 4(1):1-18.
21. Amuzescu B., Scheel O., Knott T. (2014): Novel automated patch-clamp assays on stem cell-derived cardiomyocytes: will they standardize in vitro pharmacology and arrhythmia research? J. Phys. Chem. Biophys.4(4):153.
22. Chevalier M., Amuzescu B., Gawali V., Todt H., Knott T., Scheel O., Abriel H. (2014): Late cardiac sodium current can be assessed using automated patch-clamp, F1000Research
23. Scheel O., Frech S., Amuzescu B., Eisfeld J., Lin K.-H., Knott T. (2014): Action potential characterization of human induced pluripotent stem cell-derived cardiomyocytes using automated patch-clamp technology, Assay Drug Dev. Technol. 12(8):457-69.
24. Iordache F., Constantinescu A., Andrei E., Amuzescu B., Halitzchi F., Savu L., Maniu H. (2016): Electrophysiology, immunophenotype, and gene expression characterization of senescent and cryopreserved human amniotic fluid stem cells, J. Physiol. Sci. (Epub ahead of print)