Serafim  Papadimitriou

Nilesh wagh

Scientist

biography

Senior Radiochemist Scientist- Radiomedix Inc, Houston                                                                    2014-Present

Ø   Senior radiochemist with over six years experience in radiopharmaceutical discovery and involved in programs from earliest discovery stages into clinical development.  

Ø    Characterization of Small molecules (NCE) and Peptides using Mass spectroscopy, HPLC and TLC.

Ø    Well-developed presentational, management skill and reporting to the   research group and management.

Elder Pharmaceuticals, Navi Mumbai, India Research and Development Executive                             2009-2010                                                                           

Ø  Worked on development of new chemical entities

Ø  In-depth experience on FT-IR, NMR, MS-MS and X -ray crystallography.

Ø  Successfully completed filling of 3 patent applications. Instrumental in writing provisional patent specification drafting.

Ø  Postdoctoral Research Associate (Radiochemistry)

Department of Pharmaceutical Sciences, University of Nebraska Medical Center. USA

2014

Ø  Ph.D (Pharmaceutical Chemistry)

2010

Bharati Vidyapeeth University, Poona College of Pharmacy, Pune. India.

 

 

Area of Interest

MEDICINAL CHEMISTRY . ORGANIC CHEMISTRY , PHARMACEUTICAL SCIENCES , CANCER RESEARCH


top publication

 Zhengyuan Zhou, Nilesh K. Wagh, Sunny M. Ogbomo, Wen Shi, Yinnong Jia, Susan K. Brusnahan, Jered C. Garrison. In vivo evaluation of an 111In-labeled hypoxia enhanced 111In-bombesin conjugates for specific targeting of BB2 receptors on human prostate cancers. Journal of Nuclear Medicine. 2013 54:1605-1612.  Sunny M. Ogbomo, Wen Shi, Nilesh K Wagh, Zhengyuan

Zhou, Susan K. Brusnahan, Jered C. Garrison 177Lu- labeled HPMA Copolymers Utilizing Cathepsin B and S Cleavable Linkers: Synthesis, Characterization and Preliminary In Vivo Investigation in a Pancreatic Cancer Model. Nuclear Medicine and Biology. 2013 Jul;40(5):606- 17. 

W Shi, SM Ogbomo, NK Wagh, Z Zhou, Y Jia, SK Brusnahan, JC Garrison The influence of linker length on the properties of cathepsin S cleavable 177 Lu-labeled HPMA copolymers for pancreatic cancer imaging Biomaterials 2014 , 35 (22), 5760-5770

 Y Jia, W Shi, Z Zhou, NK Wagh, W Fan, SK Brusnahan, JC Garrison Evaluation of DOTA-chelated neurotensin analogs with spacer-enhanced biological performance for neurotensin-receptor-1-positive tumor targeting  Nuclear medicine and biology2015 42 (11), 816-823

Nilesh K. Wagh, Zhengyuan Zhou, Sunny M. Ogbomo, Wen Shi, Susan K. Brusnahan, Jered C. Garrison. Development of Hypoxia Enhanced 111In-labeled Bombesin Conjugates: Design, Synthesis and In Vitro Evaluation in PC-3 Human Prostate Cancer. Bioconjugate Chemistry 2012, 23 (3), 527–537. 

Sachin L. Badole, Sagar P. Mahamuni, Pranita P. Bagul, Arvindkumar E. Ghule, Subhash L. Bodhankar, Chandrashekhar G. Raut, Evans C Coutinho, Nilesh K Wagh.Cycloart-23-ene-3β, 25-diol stimulates GLP-1 (7–36) amide secretion in streptozotocin–nicotinamide induced diabetic Sprague Dawley rats: A mechanistic approach. European journal of pharmacology, 2013,698(1-3) ,470-479

Nilesh K. Wagh, Hemantkumar S. Deokar, Badal S. Rathi, Subhash L. Bodhankar, Vithal M. Kulkarni. Anti- inflammatory and Analgesic Activity of 4’-methylbiphenyl-2- (Substituted Phenyl) Carboxamide Analogs In Animal Models of Inflammation Pharmacologyonline 2006, 2, 1-13.

 Nilesh K. Wagh, Hemantkumar S. Deokar, Dhanshri C. Juvale, Shivajirao S. Kadam, Vithal M. Kulkarni. 3D- QSAR of histone deacetylase inhibitors as anticancer agents by genetic function approximation. Indian Journal of Biochemistry & Biophysics. 2006, 43,360-371.

Dhanshri C. Juvale, Vishal V. Kulkarni, Hemantkumar S. Deokar, Nilesh K.Wagh, Subhash B. Padhye and Vithal M. Kulkarni. 3D- QSAR analysis of histone deacetylase inhibitors: hydroxamate analogues Organic Biomolecular Chemistry, 2006 4, 2858-2868.

Badal. S. Rathi, Nilesh. K. Wagh, Subhash. L. Bodhankar and Vithal. M. Kulkarni. Evaluation of Anti- Inflammatory and Analgesic Activity of a New Class of Biphenyl Analogs in Animal Models of Inflammation. Arzneim.-Forsch./Drug Res. 2006, 56, No.9, 640-646

Ujashkumar a. Shah, nilesh k. Wagh, hemantkumar s. Deokar, shivajirao s. Kadam and vithal m. Kulkarni* design, synthesis, pharmacological screening and molecular docking of biphenyl analogues as antiinflammatory agents International Journal of Pharma and Bio Sciences Vol.1/Issue-4/Oct-Dec.2010 501-511

Ujashkumar a. Shah, nilesh k. Wagh, hemantkumar s. Deokar, shivajirao s. Kadam and vithal m. Kulkarni 3d-qsar of biphenyl analogues as anti-inflammatory agents by genetic function approximation (gfa)[part-ii] International Journal of Pharma and Bio Sciences Vol.1/Issue-4/Oct-Dec.2010 512-522