Serafim  Papadimitriou

Ghassan M Saed

Associate Professor

Detroit, Michigan

biography

He is an internationally renowned clinical and translational investigator, who is recognized for many scientific contributions within the fields of Reproductive Endocrinology and Infertility and Gynecologic Oncology. His contributions include publication of over 200 peer reviewed manuscripts, 10 chapters, and 500 abstracts. Additionally he has given over 350 scientific presentations.Dr. Saed has over 20 years of experience in the pathogenesis of tissue fibrosis and cancer.He has been funded by the National Institutes of Heath to study the role of hypoxia and oxidative stress in the pathogenesis of postoperative adhesions.

 

Area of Interest

Parallel studies investigating the role of oxidative stress in the pathogenesis of ovarian cancer.
The idea of studying ovarian cancer arose from the need to compare the effects of oxidative stress on the pathogenesis of a malignant overgrowth versus a benign overgrowth, such as postoperative adhesions. These studies resulted in the identification of biomarkers for progression and metastasis of ovarian cancer


top publication

1. el-Thaher TS, Saed GM, Bailey GS. A simple and rapid purification of kallikrein from rat submandibular gland. Biochemical and Biophsical Acta 1034(2):157-161, 1990. PMID: 1693859

2.Saed GM, Carretero OA, MacDonald R, Scicli AG. Kallikrein messenger RNA in rat arteries and veins. Circulation Research 67(2):510-516, 1990. PMID: 1695871

3.Saed GM, Beierwaltes WH, Carretero OA, Scicli AG. Submandibular enzymatic vasoconstrictor messenger RNA in rat kidney. Hypertension 19 (Suppl. 2):11262-11267, 1992. PMID: 1735590
v 4.el-Thaher TS, Saed GM, Bailey GS. Characterization of kallikrein isolated from rat submandibular glands by a simple and rapid purification procedure. Agents and Action Supplement 38(Pt 1):98-105, 1992. PMID: 1466309

5.Nolly H, Saed GM, Scicli AG, Carretero OA, Scicli AG. The Kallikrein-Kinin system in cardiac tissue. Agents and Actions Supplement 38(Pt 3):62-72, 1992. PMID: 1462885

6. Nolly H, Saed G, Carretero O, Scicli AG. Adrenal kallikrein. Hypertension 21(Pt 6):911-915, 1993. PMID: 8505100

7. Valdés G, Corthorn J, Scicli AG, Gaete V, Soto J, Ortiz ME, Foradori A, Saed GM. Uterine kallikrein in the early pregnant rat. Biology of Reproduction 49(4):802-808, 1993. PMID: 8218645.

8. Joseph R, Tsang W, Han E, Saed GM. Neuoronal beta-amyloid precursor protein gene expression: Regulation by aurintricarboxylic acid. Brain Research 625(2):244-255, 1993. PMID: 8275306

9. Fivenson DR, Saed GM, Beck ER, Dunstan RW, Moore PF. T-cell receptor gene rearrangement in canine mycosis fungoides: Further support for a canine model of cutaneous T-cell lymphoma. Journal of Investigative Dermatology 102(2):227-230, 1994. PMID: 7906287.

10. Saed GM, Fivenson DP, Nickoloff BJ. Mycosis fungoides exhibits a Th1 type cell-mediated cytokine profile whereas Sezary syndrome expresses a Th2 type profile. Journal of Investigative Dermatology 103(1):29-33, 1994. PMID: 8027577.

11. Saed GM, Fivenson DP. Quantitation of interferon-gamma mRNA levels in psoralen/UVA-treated HUT-78 cells by competitive PCR. Biochemical and Biophysical Research Communication 203(2):935-942, 1994. PMID: 8093077.

12. Dillon WI, Saed GM, Fivenson DP. Borrellia burgdorferi DNA is undetectable by polymerase chain reaction in skin lesions of morphea, scleroderma and lichen sclerosus et atrophicus of patients from North America. Journal of the American Academy of Dermatology 33(4):617-620, 1995. PMID: 7673495.

13. Fivenson DP, Schaffer J, Saed GM, Beck ER, Wood GS. Absence of human T-cell lymphotropic virus genomic determinants in canine mycosis fungoides. Archives of Dermatology 132(1):841-842, 1996. PMID: 8678587 .

14. Stein L, Saed GM, Fivenson DP. T-cell cytokine network in cutaneous lupus erythematosus. Journal of the American Academy of Dermatology 36 (2 Pt 1):191-196, 1997. PMID: 9039167.

15. Ricketts CH, Martin L, Faria DT, Saed GM, Fivenson DP. Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and non-silicone gel dressings. Dermatology Surgery 22(11):955-964, 1996. PMID: 9063511.

16. Ladin DA, Hou Z, Patel D, McPhail M, Olson JC, Saed GM, Fivenson DP. p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair and Regeneration 6(1):28-37, 1998. PMID: 9776848.

17. Saed G, Ladin D, Olsen J, Han X, Hou Z, Fivenson D. Analysis of p53 gene mutations in keloids using polymerase chain reaction-based single-strand conformational polymorphism and DNA sequencing. Archives of Dermatology 134(8):963-967, 1998. PMID: 9722726.

18. Saed GM, Zhang W, Chegini N, Holmdhal L, Diamond MP. Alteration of type I and III collagen expression in human peritoneal mesothelial cells in response to hypoxia and transforming growth factor-beta1. Wound Repair and Regeneration 7(6):504-510, 1999. PMID: 10633010.

19. Wittenberg GP, Fabian BG, Bogomilsky JL, Schultz LR, Runder EJ, Chaffins ML, Saed GM, Burns RL, Fivenson DP. Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment. Archives of Dermatology 135(9): 1049-1055, 1999. PMID:10490109.

20. Saed GM, Zhang W, Chegini N, Holmdahl L, Diamond MP. Transforming growth factor beta isoforms production by human peritoneal mesothelial cells after exposure to hypoxia. American Journal of Reproductive Immunology 43(5):285-291, 2000. PMID: 10872608.

21. Saed GM, Zhang W, Diamond MP. Effect of hypoxia on the stimulatory effect of TGF-beta 1 on MMP-2 amd MMP-9 activities in mouse fibroblasts. Journal of the Society of Gynecologic Investigation 7(6):348-354, 2000. PMID:11111070[PubMed – indexed for MEDLINE].

22. Saed GM, Zhang W, Diamond MP. Molecular characterization of fibroblasts isolated from human peritoneum and adhesions. Fertility and Sterility 75(4):763-768, 2001. PMID: 11287032.

23. Chegini N, Kotseos K, Ma C, Williams RS, Diamond MP, Holmdahl L, Skinner K, Saed GM; Peritoneal Healing and Adhesion MultiUniversity Study Group. Differential expression of integrin alphav and beta3 in serosal tissues of human intraperitoneal organs and adhesion. Fertility and Sterility 75(4):791-796, 2001. PMID: 11287036.

24. Chegini N, Kotseos K, Bennett B, Diamond MP, Holmdahl L, Burns J, Saed GM; Peritoneal Healing and Adhesion MultiUniversity Study Group. Matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in peritoneal fluids and sera and correlation with peritoneal adhesions. Fertility and Sterility 76(6):1207-1211, 2001. PMID: 11730752.

25. Chegini N, Kotseos K, Zhao Y, Ma C, McLean F, Diamond MP, Holmdahl L, Burns J, Saed GM; Peritoneal Healing and Adhesion Multi-University Study (PHAMUS) Group. Expression of matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in serosal tissue of intraperitoneal organs and adhesions. Fertility and Sterility 76(6):1212-1219, 2001. PMID: 11730753.