Serafim  Papadimitriou

Tsong-Long Hwang

Professor & Director

Kwei-Shan, Taoyuan, Taiwan


Professional History: 2013-present Director Division of Natural Products Graduate Institute of Biomedical Sciences Chang Gung University, Taiwan 2010-present Deputy Director School of Traditional Chinese Medicine Chang Gung University, Taiwan 2009-present Professor Graduate Institute of Natural Products Chang Gung University, Taiwan 2005-2009 Associate Professor Graduate Institute of Natural Products Chang Gung University, Taiwan 2000-2005 Assistant Professor Graduate Institute of Natural Products Chang Gung University, Taiwan Education: 1996- 2000 Ph.D. Pharmacology Graduate Institute of Pharmacology NationalTaiwanUniversity 1991-1993 M.S. Pharmacology Graduate Institute of Medicine KaohsiungMedicalCollege 1987-1991 B.S. Pharmacy School of Pharmacy KaohsiungMedicalCollege


Area of Interest

1) Inflammopharmacology
2) Innate immunity
3) Signal transduction
4) Protein kinase
5) Phytopharmacology
6) Drug research and development.

top publication

1. Hwang TL*, Li GL, Lan YH, Chia YC, Hsieh PW, Wu YH, Wu YC. Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigmaoldhamii. Free RadicBiol Med. 2009 Feb 15; 46(4):520-8.

2. Hwang TL*, Su YC, Chang HL, LeuYL, Chung PJ, Kuo LM, Chang YJ. Suppression of superoxide anion and elastase release by C18 unsaturated fatty acids in human neutrophils. J Lipid Res. 2009 Jul;50(7):1395-408.

3. Chen JJ, Chung CY, Hwang TL, Chen JF. Amides and benzenoids from Zanthoxylumailanthoides with inhibitory activity on superoxide generation and elastase release by neutrophils. J Nat Prod. 2009 Jan;72(1):107-11.

4. Chen JJ, Ting CW, Hwang TL, Chen IS. Benzophenone derivatives from the fruits of Garcinia multiflora and their anti-inflammatory activity. J Nat Prod. 2009 Feb 27;72(2):253-8.

5. Lin AS, Lin CR, Du YC, Lübken T, Chiang MY, Chen IH, Wu CC, Hwang TL, Chen SL, Yen MH, Chang FR, Wu YC. Acasiane A and B and farnesirane A and B, diterpene derivatives from the roots of Acacia farnesiana. Planta Med. 2009 Feb;75(3):256-61.

6. Yen CT, Hsieh PW, Hwang TL, Lan YH, Chang FR, Wu YC. Flavonol glycosides from muehlenbeckiaplatyclada and their anti-inflammatory activity. Chem Pharm Bull (Tokyo). 2009 Mar;57(3):280-2.

7. Yen CT, Hwang TL, Wu YC, Hsieh PW. Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents. Eur J Med Chem. 2009 May; 44(5):1933-40.

8. Hwang TL, Su YD, Hu WP, Chuang LF, Sung PJ. Rumphellolide H, a new natural caryophyllane from the Gorgonian Rumphella antipathies. Heterocycles. 2009; 78(6):1563-7.

9. Fang JY, Hung CF, Hua SC, Hwang TL*. Acoustically active perfluorocarbon nanoemulsions as drug delivery carriers for camptothecin: drug release and cytotoxicity against cancer cells. Ultrasonics. 2009 Jan; 49(1):39-46.

10. Hsieh PW, Hsu LC, Lai CH, Wu CC, Hwang TL, Lin YK, Wu YC. Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants. World J MicrobiolBiotechnol. 2009; 25(8):1461-9.

11. Sung PJ, Su YD, Hwang TL, Chuang LF, Chung HM, Chen JJ, Li JJ, Fang LS, Wang WH. Rumphellolide I, a novel caryophyllane-related tetrahydropyrannorsesquiterpenoid from gorgonian coral Rumphella antipathies. Chem Lett. 2009; 38(3):282-3.

12. Huang YC, Hwang TL (equal first author), Chang CS, Yang YL, Shen CN, Liao WY, Chen SC, Liaw CC. Anti-inflammatory Flavonoids from the Rhizomes of Helminthostachyszeylanica. J Nat Prod. 2009 Jul; 72(7):1273-8.

13. Lin YK, Leu YL, Huang TH, Wu YH, Chung PJ, Su Pang JH, Hwang TL*. Anti-inflammatory effects of the extract of indigo naturalis in human neutrophils. J Ethnopharmacol. 2009 Aug 17; 125(1):51-8.

14. Sung PJ, Lin MR, Chiang MY, Hwang TL. Briaexcavatins V-Z, discovery of new briaranes from a cultured octocoralbriareumexcavatum. Bull ChemSocJpn. 2009; 82(8):987-96.

15. Sung PJ, Chen BY, Lin MR, Hwang TL, Wang WH, Sheu JH, Wu YC. Excavatoids E and F: Discovery of two new briaranes from the cultured octocoralBriareumexcavatum. Mar Drugs. 2009 Sep 23; 7(3):472-82.

16. Hwang TL, Fang CL, Chen CH, Fang JY. Permeation enhancer-containing water-in-oil nanoemulsions as carriers for intravesical cisplatin delivery. Pharm Res. 2009 Oct; 26(10):2314-23.

17. Chung HM, Hwang TL, Wang WH, Fang LS, Sung PJ. Curcuphenol derivatives from the gorgonian Echinomuricea sp. Heterocycles. 2009; 78(10):2595-600.

18. Wang SS, Chen YH, Chang JY, Hwang TL, Chen CH, Khalil AT, Shen YC. Juncenolides H-K, new briaranediterpenoids from Junceellajuncea. HelvChimActa. 2009; 92(10):2092-100.

19. Hwang TL, Lin YK, Chi CH, Huang TH, Fang JY. Development and evaluation of perfluorocarbon nanobubbles for apomorphine delivery. J Pharm Sci. 2009 Oct; 98(10):3735-47.

20. Chung YC, Hu YW, Hwang TL, Chen PW, Sie FJ. Acting force comparison of microbeads and hemocytes in microchannel using optical tweezers system. 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 , art. no. 5068750 , pp. 1036-1039.