Serafim  Papadimitriou

Jianxun Song

Associate Professor

biography

Dr. Jianxun (Jim) Song is a tenured associate professor in the Department of Microbiology and Immunology, the Pennsylvania State University College of Medicine,United States. The base of expertise on T cell biology needed to perform his researchbegan to develop while he was a postdoctoral scholar and research scientist from the years 2001-2007 under the mentorship of Dr. Michael Croft at the La Jolla Institute for Allergy and Immunology. He became a junior faculty at The Pennsylvania State University College of Medicine in 2007, and extended his research on Developmental Immunology and Stem Cell Biology. As a PI on previous university-,foundation-, or NIH-funded grants, he laid the groundwork for the research by developing highly reactive T lymphocytes from pluripotent stem cells (PSC). His laboratory was the first to show that induced PSC differentiate into functional T cells for cell-based therapies. In addition to having the expertise to be successful with the research, he offers leadership and administrative skills that were developed during his independence as a mentor of graduate students and postdoctoral scholars. In summary, he has a demonstrated record of successful and productive research projects in the area.

 

Area of Interest

1)T lymphocyte memory
2)vaccine design
3)autoimmune diseases
4)autoimmune therapy
5)immune-based anti-cancer
6)T cell persistence
7)tumor regression


top publication

1. Haque M, Fino K, Lei F, Xiong X, and Song J (2014). Utilizing regulatory T cells against rheumatoid arthritis. Front Oncol, 4: 209

2. AĝirbaÅŸli MA, Song J, Lei F, Wang S, Kunselman AR, Clark JB, Myers JL, Ündar A (2014).Comparative effects of pulsatile and nonpulsatile flow on plasma fibrinolytic balance in pediatric patients undergoing cardiopulmonary bypass. Artif Organs, 38(1): 28-33

3. Tian Y, Ni D, Yang W, Zhang Y, Zhao K, Song J, Mao Q, Tian Z, van Velkinburgh JC, Yang D, Wu Y, Ni B (2014). Telbivudine treatment corrects HBV-induced epigenetic alterations in liver cells of patients with chronic hepatitis B. Carcinogenesis, 35(1): 53-61.

4. Lei F, Song J, Haque R, Xiong X, Fang D, Wu Y, Lend SM, Croft M and Song J (2013). Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol, 43 (7): 1914-1924. PMCID: PMC3876962

5. Lei F, Song J, Haque R, Xiong X, Fang D, Croft M and Song J (2013). Regulation of A1 by OX40 contributes to CD8 T cell survival and anti-tumor activity. PLoS One, 8(8): e70635. PMCID: PMC3731243

6. Kemp KL, Lin Z, Zhao F, Gao B, Song J, Zhang K, Fang D (2013). The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells. J Biol Chem, 288(46): 33272-82. PMCID: PMC3829173

7. Tian Y, Yang W, Song J, Wu Y, Ni B (2013). Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis. Mol Cell Biol, 33(15): 2810-6. PMCID: PMC3719687

8. Haque R, Lei F, Xiong X, Bian Y, Zhao B, Wu Y and Song J (2012). Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol 189 (3): 1228-1236. PMCID: PMC3401327

9. Lei F, Haque R, Xiong X, and Song J (2012). Directed differentiation of induced pluripotent stem cells towards T lymphocytes. J Vis Exp. (63), e3986. PMCID: PMC3389997

10. Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J, Zhang DD, and Fang D (2012). USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development. Mol Cell, 46(4): 484-494. PMID: 22542455

11. Lei F, Haque R, Xiong X, Budgeon L, Christensen ND, Wu Y and Song J (2011). In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. Cancer Res, 71(14): 4742-4747. PMID: 21628492

12. Tian Y, Jia Z, Wang J, Huang Z, Tang J, Zheng Y, Tang Y, Wang Q, Tian Z, Yang D, Zhang Y, Fu X, Song J, Liu S, van Velkinburgh JC, Wu Y, Ni B (2011). Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells. PLoS One. 2011; 6(11):e27770. PMID: 22132139

13. Haque R, Lei F, Xiong X, and Song J (2011). The regulation of FoxP3-expressing regulatory T cells. Endocr Metab Immune Disord Drug Targets, 11: 334-336. PMID: 21696363

14. Haque R, Lei F, Xiong X, Wu Y, and Song J (2010). FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther 12(2): R66. PMID 19454669

15. Lei F, Haque R, Weiler L, Vrana KE, and Song J (2009). T lineage differentiation from induced pluripotent stem cells. Cell Immunol 260 (1): 1-5. PMID 19811778

21. Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, Wu Y, Croft M, and Song J (2009). Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol 182 (11): 6744-6752. PMID 19454669

16. Song J, So T and Croft M (2008). Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol 180(11): 7240-7248. PMCID: PMC2410213

17. Song J, Lei F, Xiong X and Haque R (2008). Intracellular signals of T cell costimulation. Cell Mol Immunol 5 (4): 239-247. PMID 18761811

24. Song J, Salek-Ardakani S, So T, and Croft M (2007). The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol 8 (1): 64-73. PMID: 17128276

18. Song A, Song J, Tang X, Croft M (2007). Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol 37(5): 1224-1232. PMID 17429847

19. So T, Song J, Sugie K, Altman A, and Croft M (2006). Signals from OX40 regulate NFATc1 and Th2 lineage commitment. Proc Natl Acad Sci U S A 103(10): 3740-3745. PMCID:PMC1450148

20. Song J, So T, Cheng M, Tang X and Croft M (2005). Sustained Survivin expression from OX40 costimilatory signals drives T cell clonal expansion. Immunity 22(5): 621-631. PMID:15894279

21. Barouch-Bentov R, Lemmens EE, Hu J, Janssen EM, Droin NM, Song J, Schoenberger SP,Altman A (2005). Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8): 5126-5134. PMID: 16210616

29. Song J, Salek-Ardakani S, Rogers PR, Cheng M, Parijs LV, and Croft M (2004). The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol 4(2): 150-158. PMID 14730361

Book
1. Song J (2015). Frontiers in Cancer Immunotherapy - Mechanisms of cancer immunity, engineering immune-based therapies and developing clinical trials. Bentham Science Publishers, UAE, in press

Book chapters
2. Lei F, Haque R, Xiong X, and Song J (2014). Modulation of autoimmune diseases by iPS cells. Animal Models for Stem Cell Therapy: Methods and Protocols. Springer Science, New York

3. Lei F, Haque R, Xiong X, and Song J (2014). Generation of antigen-specific T lymphocytes from induced pluripotent stem cells for adoptive immunotherapy. Stem Cells and Cancer Stem Cells, Volume 10. Springer Science, Dordrecht

4. Haque R, Lei F, Xiong X, and Song J (2012). Stem cell-based cellular therapy in rheumatoid arthritis. Autoimmune Diseases. InTech Europe 5. Croft M, Salek-Ardakani S, Song J, So T, and Bansal-Pakala P (2003). Regulation of T cell immunity by OX40 and OX40L. The TNF Superfamily. Landes Bioscience, Texas.

Awards
2009 - 2014 AAI Junior Faculty Travel Awards (Seattle, Baltimore, Boston, Honolulu, and Pittsburgh)
2011 - 2013 Dean’s Awards for Excellence in Teaching (Penn State University College of Medicine)
2014 - 2017 Graduate Council, The Graduate School, Penn State University
2014 Postdoctoral Mentorship Award (Penn State University College of Medicine)
2014 - 2015 Woodward Education Scholar Award
2015 - 2018 Penn State University Faculty Senate