Serafim  Papadimitriou

Meiqing Shi

Assistant Professor

biography

I was educated in China and received my DVM in South China Agricultural University. I went to Germany and got my PhD in the Faculty of Veterinary Medicine, University of Giessen. During my PhD training, I worked on coccidiosis, a serious disease in chicken and cattle. I moved to Canada and received my postdoctoral training in the Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, where I worked with Henry Tabel in the area of immunopathogenesis of African trypanosomes. Later I moved to the University of Calgary and worked with Chris Mody on fugal pathogen Cryptococcus neoformans, until I was recruited as Assistant Professor to the Department of Veterinary Medicine, University of Maryland College Park.

 

Area of Interest

1)Host-pathogen interactions
2)Molecular mechanisms involved in brain invasion by Cryptococcus neoformans and Trypanosomabrucei
3)Immune responses to C. neoformans and T. brucei
4)Roles of T cells and cytokines in immunopathogenesis of T. brucei- infection.


top publication

1. Liu, G., Sun, D., Wu, H., Zhang, M., Huan, H., Xu, I., Zhang X., Zhou, H., Shi, M. Distinct contributions of CD4+ and CD8+ T cells to pathogenesis of Trypanosoma brucei infection in the context of gamma interferon and Interleukin-10. Infection and Immunity, 83: 2785-2795, 2015

2. Li, S.S., Kyei, S.K., Timm-McCann, M., Ogbomo, H., Jones, G.J., Shi, M., Xiang, R.F., Oykhman, P., Huston, S.M., Gill, M.J., Robbins, S.M., & Mody, C.H. The NK Receptor NKp30 Mediates Direct Fungal Recognition and Killing and Is Diminished in NK Cells from HIV-Infected Patients. Cell Host Microbe, 14: 387-397, 2013

3. Moriarty, T.J., Shi, M., Lin Y.P., Ebady, R., Zhou, H., Odisho, T., Hardy, P.O., Salman-Dilgimen, A., Wu, J., Weening, E.H., Skare, J.T., Kubes, P., Leong, J., & Chaconas, G. Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Molecular Microbiology, 86: 1116-1131, 2012

4. Shi, M., Calaruso P. & Mody, C.H. Real-time in vivo imaging of fungal migration to the CNS. Cellular Microbiology, 14: 1819-1827, 2012

5. Shi M., Wang A, Prescott D, Waterhouse C, Zhang S, McDougall JJ, Sharkey KA, McKay DM. Infection with an intestinal helminth parasite reduces Freund’s complete adjuvant-induced mono-arthritis in mice. Arthritis & Rheumatism, 63: 434-444, 2011

6. Shi M., Li SS, Zheng CF, Jones GJ, Kim KS, Zhou, Z, Kubes P, Mody CH. Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain. Journal of Clinical Investigation, 120: 1683-1693, 2010

7. Tabel H, Wei G, Shi M. T cells and immunopathogenesis of experimental African trypanosomiasis. Immunological Reviews, 225: 128-139, 2008

8. Zheng CF, Jones GJ, Shi M., Wiseman JC, Marr KJ, Berenger BM, Huston SM, Gill MJ, Krensky AM, Kubes P, Mody CH. Late expression of granulysin by microbicidal CD4+ T cells requires PI3K- and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients. Journal of Immunology, 180: 7221-7229, 2008

9. Shi M., Ye Z, Umeshappa KS, Moyana T, Xiang J. (2007) Alpha tumor necrosis factor contributes to CD8+ T cell survival in the transition phase. Biochemical and Biophysical Research Communications, 360: 702-707, 2007

10. Shi M., Wei G, Tabel H. Trypanosoma congolense Infections: MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function. Parasite Immunology, 29: 107-111, 2007

11. Shi M., Wang CR, Wei G., Pan P, Appleyard G, Tabel H. Experimental African trypanosomiasis: lack of effective CD1d-restricted antigen presentation. Parasite Immunology, 28: 643-647, 2006

12. Shi, M., Hao, S., Chan, T. & Xiang, J. CD4+ T cells stimulate memory CD8+ T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion. Journal of Leukocyte Biology, 80: 1354-1363, 2006

13. Shi, M. & Xiang, J. CD4+ T cell-independent maintenance and expansion of memory CD8+ T cells derived from in vitro dendritic cell activation. International Immunology, 18: 887-895, 2006

14. Shi M, Wei G, Pan W, Tabel H. Experimental African trypanosomiasis: a subset of pathogenic, IFN--producing, MHC-II-restricted CD4+ T cells mediates early mortality in highly susceptible mice. Journal of Immunology, 176: 1724-1732, 2006

15. Pan W, Ogunremi O, Wei G, Shi M, Tabel H. CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of TNF-α and nitric oxide. Microbes and Infection, 8: 1209-1218, 2006

16. Shi M, Wei G., Pan W, Tabel H. Impaired Kupffer cells in highly susceptible mice infected with Trypanosoma congolense. Infection and Immunity, 73: 8393-8396, 2005

17. Shi M., Wei G., Pan P, Tabel H. Trypanosoma congolense infections: antibody-mediated phagocytosis by Kupffer cells. Journal of Leukocyte Biology, 76: 399-405, 2004

18. Shi M., Pan W, Tabel H. Experimental African trypanosomiasis: IFN- mediates early mortality. European Journal of Immunology, 33: 108-118, 2003

19. Shi M., Hirzmann J, Dafaalla TH, Zahner H. In vivo expression profiles of cytokine and iNOS mRNAs in rats infected with Eimeria separata. Veterinary Parasitology, 97: 131-140 2001

20. Shi M., Huther S, Burkhardt E, Zahner H. Lymphocyte subpopulations in the caecum mucosa of rats after infections with Eimeria separata: early responses in naïve and immune animals to primary and challenge infections. International Journal for Parasitology, 31: 49-55 2001