Serafim  Papadimitriou

Jeffrey Pu

Assistant Professor


Jeffrey J. Pu, MD, Ph.D. is an assistant professor of medicine, pathology, and Biomedical Science Graduate Program at the Penn State Hershey Cancer Institute and Penn State College of Medicine. Prior to this position, Jeff was a senior clinical/research fellow of Hematology/Oncology at the Sidney Kimmel Comprehensive Cancer Center of Johns Hopkins University. Jeff also completed a NIH supported experimental hematology fellowship and a clinical transfusion medicine/blood banking fellowship at the Lindsley F. Kimball Research Institute of New York Blood Center after completed an internal medicine residency at Mount Sinai School of Medicine. Jeff received his Ph.D. from New York Medical College in New York and his MD from Shanghai Jiao Tong University School of Medicine in Shanghai.


Area of Interest

Jeff is always interested in hematopoiesis and stem cell biology. He is pursuing an exciting career as physician-scientist. Currently, Jeff is focusing on bone marrow clonal disease translational research,especially on mechanisms of genomic instability/leukemic transformation and immunopathogenesis of hematopoietic failure disorders

top publication

1.DeZern AE, Uknis M, Yuan X, Mukhina GL, Varela J, Saye J, Pu J, Brodsky A.Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria. Exp Hematol. 2014 Oct; 42(10):857-861.e1.
2.Pu JJ, Sido A. Successful discontinuation of eculizumab therapy in a patient with aHUS. Ann Hematol. 2014 Aug; 93(8):1423-5.
3.DeZern AE, Pu J, McDevitt MA, Jones RJ, Brodsky RA. Burst-forming unit-erythroid assays to distinguish cellular bone marrow failure disorders. Exp Hematol. 2013 Sep; 41(9):808-16.
4.Pu JJ, Hu R, Mukhina GL, Carraway HE, McDevitt MA, Brodsky RA. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells. Haematologica. 2012 Aug; 97(8):1225-33.
5.Pu JJ, Mukhina G, Wang H, Savage WJ, Brodsky RA. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia. Eur J Haematol. 2011 Jul; 87(1):37-45.
6.Pu JJ, Brodsky RA. Paroxysmal nocturnal hemoglobinuria from bench to bedside. Clin Transl Sci. 2011 Jun; 4(3):219-24.
7.Pu JJ, Wu W. Gallbladder carcinosarcoma. BMJ Case Rep. 2011; 2011.
8.Araten DJ, Sanders KJ, Pu J, Lee S. Spontaneously arising red cells with a McLeod-like phenotype in normal donors. Mutat Res. 2009 Dec 1; 671(1-2):1-5.
9.Pu JJ, Redman CM, Visser JW, Lee S. Onset of expression of the components of the Kell blood group complex. Transfusion. 2005 Jun; 45(6):969-74.
10.Kiskowski MA, Alber MS, Thomas GL, Glazier JA, Bronstein NB, Pu J, Newman SA. Interplay between activator-inhibitor coupling and cell-matrix adhesion in a cellular automaton model for chondrogenic patterning. Dev Biol. 2004 Jul 15; 271(2):372-87.
11.Moftah MZ, Downie SA, Bronstein NB, Mezentseva N, Pu J, Maher PA, Newman SA. Ectodermal FGFs induce perinodular inhibition of limb chondrogenesis in vitro and in vivo via FGF receptor 2. Dev Biol. 2002 Sep 15; 249(2):270-82.
12.Pu JJ, Li C, Rodriguez M, Banerjee D. Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. Cytokine. 2001 Feb 7; 13(3):129-37.
13.Lee S, Russo DC, Pu J, Ho M, Redman CM. The mouse Kell blood group gene (Kel): cDNA sequence, genomic organization, expression, and enzymatic function.Immunogenetics. 2000 Nov; 52(1-2):53-62.
14.Finger LR, Pu J, Wasserman R, Vibhakar R, Louie E, Hardy RR, Burrows PD, Billips LG. The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors. Gene. 1997 Sep 15; 197(1-2):177-87.