Serafim  Papadimitriou

Paula Y. P Lam

Associate Professor

biography

A/Prof. Paula Lam, Ph.D. is a principal investigator at the National Cancer Center in Singapore. She is also an adjunct associate professor at the National University of Singapore, Department of Physiology and at Duke-NUS Graduate Medical School, Program in Cancer & Stem Cell Biology. Paula received her PhD in Biochemistry and Molecular Biology at University of Leeds, UK. She completed postdoctoral fellowships at St. Jude Childrens’ Research Hospital and Chinese University of Hong Kong and subsequently, obtained training in gene therapy against brain tumors at Massachusetts General Hospital, Department of Neurogenetics. 

 

Area of Interest

Cancer research
Gene and Cell Therapy
Tumor Tropism of Mesenchymal Stem Cells
Glioma Receptor Signaling


top publication

1. JKY Chan and Lam PY. “Soluble factors from human fetal bone marrow-derived mesenchymal stem cells to treat tumor: preparation of conditioned medium and its effect on tumor cells”. In press Methods in Mol. Biology, 2015
2. Chong QQ, Toh XY, Ho IAW, Sia KC, Newman JP, Yulyana Y,Ng WH, Lai SH, Ho MF, Tham CK*, Lam PY*. “Epidermal growth factor status in human glioma cells dictates responsiveness to nimotuzumab treatment” BMC Cancer, 15:255
3. Yulyana Y, Ho IAW, Sia KC, Newman JP, Toh XY, Berwini B Endaya, Chan J, Gneicchi M, Huynh H, Chung AY, Kiat Hon Lim, Leong HS, Iyer GN, Hui KM, Lam PY “Human fetal mesenchymal stem cells inhibit hepatocellular carcinoma growth through IGF-1R/PI3K/Akt”, Mol Therapy, 23, 746-756, 2015
4. Ho IAW, Yulyana Y, Sia KC, Newman JP, Guo CM, Hui KM, Lam PY. “Matrix metalloproteinase-1 mediated mesenchymal stem cells tumor tropism is dependent on crosstalk with stromal derived growth factor-1/C-X-C chemokine receptor-4 axis” FASEB J 28, 4359-4368, 2014
5. Lv M, Fraefel C, Sia KC, Newman JP, Shafiq Ali Bin Mohamed Bashir , Ng WH and Lam PY. The potential application of regulatable oncolytic herpes simplex virus in treating human cancers, British Journal of Cancer, 110, 94-106, 2014
6. Lam PY. “Biological effects of cancer secreted factors on human mesenchymal stem cells”, Stem Cells Research and Therapy”, 4: 138, 2013
7. Chan JKY and Lam PY. Human mesenchymal stem cells and its paracrine factors for the treatment of brain tumors, Cancer Gene Therapy, 20: 539-543, 2013
8. Ho IAW and Lam PY. Signaling Molecules and Pathways involved in MSC tumor tropism, Histol Histopathol. 28: 1427-1438, 2013
9. Sia KC, Huynh H, Chung AYF, Ooi LLPJ, Lim KH, Hui KM and Lam PY. Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model, Molecular Cancer Therapeutics, 12: 1651-1654, 2013
10. Yulyana Y, Endaya B, Ng WH, Guo CM, Hui KM, Lam PY, Ho IA. Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of Gap Junction Intercellular Communication\\\" Stem Cells and Development, 22; 1870-1820, 2013
11. Lam PY, Khan G, Stripecke R, Hui KM, Kasahara N, Peng KW, Guinn B*.The Innovative Evolution of Cancer Gene and Cellular Therapies” Cancer Gene Therapy 20; 141-149, 2013
12. Lam PY and Ho IA. Tumor trophic migration of mesenchymal stem cells in Stem Cell based Therapeutics for Cancer. Khalid Shah (Ed). Wiley-Blackwell. In press. (2013).
13. Ho IAW, Toh HC, Teo YL, Guo CM, Hui KM and Lam PY “Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis”, Stem Cells. 31: 146-155, 2013
14. Sia KC, Huynh H, Chinnasamy D, Hui KM, Lam PY “Suicidal gene therapy in the effective control of primary human hepatocellular carcinoma as monitored by noninvasive bioimaging.” Gene Ther. 19: 532-42, 2012
15. Newman JP, Toh XY, Chan JKY, Endaya B, Lam PY. “Migration of human fetal bone marrow-derived mesenchymal stem cells: possible involvement of GPCR and MMPs, e pub Journal of Stem Cell Research and Therapy, special issue S2, Nov 2011
16. Kannaiyan K, Manu KA, Chen L, Li F, Rajendran P, Subramaniam A, Lam P, Kumar AP, Sethi G, “Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-Terminal Kinase and suppression of PI3K/Akt signaling pathways”, Apoptosis 16:1028-41, 2011
17. Ho IA, Ng WH, Lam PY “FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors”, Mol Cancer 9: 270, 2010
18. Sia KC, Chong WK, Ho IA, Yulyana Y, Endaya B, H Huynh and Lam PY “Hybrid HSV/EBV amplicon viral vectors confer higher transgene expression in primary human tumors and human bone-marrow-derived mesenchymal stem cells”, J Gene Medicine, 12: 848-858, 2010
19. Ho IA, Hui KM, Lam PY “Isolation of peptide ligands that interact specifically with human glioma cells”, Peptides 31, 644-650, 2010 (IF 2.654; 5 year impact factor is 2.513)
20. Ho IA, Lv M, Sia KC, Wang GY, Hui KM, and Lam PY. “Targeting human glioma cells using HSV-1 amplicon peptide display vector”, Gene Therapy 17, 250-260, 2010
21. Ho IA, Chan KWY, Ng WH, Guo CM, Hui KM, Cheang P, and Lam PY. “Matrix metalloproteinase 1 is necessary for the migration of human bone marrow-derived mesenchymal stem cells”, Stem Cells 27(6): 1366-1375 2009
22. Ho IA, Chan KWY, LV M, Shim WSM, Guo CM, Cheang P, Hui KM, and Lam PY. “HSV-1 amplicon vector mediated gene transfer to human bone marrow-derived mesenchymal stem cells”, Cancer Gene Therapy, 15(9), 553-562, 2008
23. Tan K, Cheang P, Ho IA, Lam PY, and Hui KM. “Nano-sized bio-ceramic particles could function as efficient gene delivery vehicles with target specificity for the spleen”, Gene Therapy 14, 828-835, 2007
24. Lam PY, Sia KC, Khong JH, de Geest B., Lim KS, Ho IA, Wang GY, Lv M, Huynh H, Hui KM. “An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas”, Mol Ther. 15(6): 1129-36, 2007
25. Sia KC, Wang GY, Ho IA, Khor HY, Lv M, Hui KM, and Lam PY. “Optimal purification method for herpes-based viral vectors that confers minimal cytotoxicity for systemic route of vector administration”, Journal of Virological Methods, 139 (2), 166-174, 2007