Serafim  Papadimitriou

Wen Qiu

Associate professor

biography

Dr. Wen Qiu is currently an associate professor at Department of Immunology of Nanjing Medical University.He completed his PH.D from same University. previously he worked as Visiting scholar,Department of Immunology Lerner Research Institute, Cleveland Clinic, USA.wen qiu has good number of Publications and memberships in Chinese Society for Immunology Jiangsu Society for Immunology.

 

Area of Interest

1) The mechanisms of glomerular mesangial cell (GMC) apoptosis and proliferation in human mesangial proliferative glomerulonephritis (MsPGN)
2) Effects of ubiquitination and acetylation modification on the activation of signaling molecules, transcription factors and histones
3)Immunology


top publication

[1] Qiu W, Zhou JB, Zhu GQ, Zhao D, He FX, Zhang J, Lu YL, Yu TY, Liu LS, Wang YW*. Sublytic C5b-9 triggers glomerular mesangial cell apoptosis via XAF1 gene activation mediated by p300-dependent IRF-1 acetylation. Cell Death Dis. 2014; 5:e1176.

[2] Feng GZ, Jiang QT, Xia M, Lu YL, Qiu W, Zhao D, Lu LW, Peng GY, Wang YW*. Enhanced immune response and protective effects of nano-chitosan-based DNA vaccine encoding T cell epitopes of Esat-6 and FL against Mycobacterium tuberculosis infection. PLoS One. 2013; 8(4):e61135.

[3] Qiu W, Zhang Y, Liu XM, Zhou JB, Li Y, Zhou Y, Shan K, Xia M, Che N, Feng XF, Zhao D, Wang YW*. Sublytic C5b-9 complexes induce proliferative changes of glomerular mesangial cells in rat Thy-1 nephritis through TRAF6-mediated PI3K-dependent Akt1 activation. J Pathol. 2012; 226(4):619-632.

[4] Qiu W, Che N, Feng XF, Xia M, Wang H, Zhao D, Wang YW*. Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45gamma upregulation. Eur J Immunol. 2009; 39(11):3251-3266.

[5] Liu LS#, Qiu W#, Wang H#, Li Y, Zhou JB, Xia M, Shan K, Pang RR, Zhou Y, Zhao D, Wang YW*. Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation. J Biol Chem. 2012; 287(20):16410-16423. (# co-first author)

[6] Qiu W, Li Y, Zhou JB, Zhao CH, Zhang J, Shan K, Zhao D, Wang YW*. TSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis rats. J Biom Res. 2011; 25(6):402-410.

[7] Gao LJ, Qiu W, Wang YW*, Xu WH, Xu J, Tong JX. Sublytic complement C5b-9 complexes induce thrombospondin-1 production in rat glomerular mesangial cells via PI3-k/Akt: association with activation of latent transforming growth factor-beta1. Clin Exp Immunol. 2006; 144(2):326-334.

[8] Xu JH, Qiu W, Wang YW*, Xu J, Tong JX, Gao LJ. Gene expression profile and overexpression of apoptosis-related genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis model. Cell Tissue Res. 2006; 326(1):159-168.

[9] Xu KF, Zhou Y, Qiu W, Liu X, Xia M, Liu LS, Liu XM, Zhao D, Wang YW*. Activating transcription factor 3 (ATF3) promotes sublytic C5b-9-induced glomerular mesangial cells apoptosis through up-regulation of Gadd45α and KLF6 gene expression. Immunobiology. 2011; 216(8):871-881.

[10] Gao LJ, Zhang Y, Qiu W, Xu WH, Feng XF, Ren J, Jiang XM, Wang H, Zhao D, Wang YW*. Effects of PI3-k/Akt short hairpin RNA on proliferation, fibronectin production and synthesis of thrombospondin-1 and transforming growth factor-beta1 in glomerular mesangial cells induced by sublytic C5b-9 complexes. Cell Prolif. 2009; 42(1):83-93

. [11] Jiang XM, Zhang J, Xia M, Qiu W, Wang H, Zhao D, Wang YW*. Role of activating transcription factor 3 (ATF3) in sublytic C5b-9-induced glomerular mesangial cell apoptosis. Cell Mol Immunol. 2010; 7(2): 143-151.

[12] Shan K, Qiu W, Li Y, Zhou JB, Liu LS, Zhao Dan, Wang YW*. Construction of rat Caspase 8 promoter and identification of its binding sequence with IRF-1. Acta Univ Med Nanjing (in Chinese). 2013; (3):291-296.

[13] Zhao D, Li Y, Zhou JB, Zhan J, Qiu W*, Wang YW*. The proliferative lesions of rat Thy-1 nephritis and the role of sublytic C5b-9 in glomerular mesangial cell proliferation. Acta Univ Med Nanjing (in Chinese). 2012; 32(10):1343-1350. (* corresponding author)

[14] Qiu W, Li Y, Zhou JB, Zhao Dan, Wang YW*. Effects of silencing TSP-1 gene on sublytic C5b-9-induced ECM secretion from glomerular mesangial cell. The Journal of Xi’an Jiaotong University (in Chinese). 2012; 33(1):29-34.

[15] Zhou JB, Qiu W, Lu YL, Shan K, Zhao D, Wang YW*. Construction of rat XAF1 promoter and identification of its binding sequence with IRF-1. Acta Univ Med Nanjing (in Chinese).

Awards
The Young Scholar Award of Chinese Society for Immunology, Chinese Society for Immunology, 2012.