Administering of Local Anesthesia with Bupivacaine in the Patients Undergoing Inguinal Hernia Repair
Mehrdad Hosseinpour1, Leila Gafoor2, Ebrahim Kouchaki3, Mohammadreza Razavizadeh4, Mohsen Kolahdouzan5*
Affiliation
1Department of General Surgery, Faculty of medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Surgery, Faculty of medicine, Kashan University of Medical Sciences, Iran
3Department of Neurology, Faculty of medicine, Kashan University of Medical Sciences, Iran
4Department of Anesthesiology, Faculty of medicine, Kashan University of Medical Sciences, Iran
5Department of Surgery, Faculty of medicine, Isfahan University of Medical Sciences, Iran
Corresponding Author
Mohsen K, Associate Professor, Department of surgery, Isfahan University of medical sciences, Isfahan, Iran, Tel: +98 31 36202020; +989131153035/ Fax: +98 31 36684510; E-mail: kolahdouzan@med.mui.ac.ir
Citation
Kolahdouzan, M., et al. Administering of Local Anesthesia with Bupivacaine in the Patients Undergoing Inguinal Hernia Repair. (2018) J Anesth Surg 5(1): 71- 74.
Copy rights
© 2018 Kolahdouzan, M. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Background: postoperative pain is a most prevalence complication in herniorrhaphy whatever the management of this pain is a basic problem. The aim of this study was to compare the effects of pre and post incisional infiltration of the surgical area with bupivacaine on cortisol and prolactin release and postoperative pain in patients undergoing inguinal hernia repair.
Methods: In this clinical trial study, 48 adult male patients have undergone inguinal hernia repair and spinal anesthesia, assigned to 2 groups. Local anesthesia was performed by 2 mg/kg bupivacaine 0.5% while placebo group did not receive any local anesthesia. Plasma cortisol and prolactin were compared in both groups.
Results: In postoperatively, the plasma concentration of cortisol and prolactin in local anesthesia group were significantly lower than placebo group (P = 0.001 and P = 0.013, respectively). Visual Analog Scale (VAS) in local anesthesia group was significantly lower than placebo group in 12, 24, 48 and 72 hrs after operation (P < 0.0001, for all four). Also, there was a significant correlation between the two groups according to rescues analgesic (P < 0.0001).
Conclusions: The finding of the current study suggests that usage of local anesthesia is a safe, effective and feasible procedure as decreases the cortisol and prolactin hormones, postoperative pain and analgesic drugs consumption.
