Carboxyhemoglobin and Methemoglobin as Markers of Postoperative Pulmonary Complications
Aleksandra Gavrilovska-Brzanov1*, Maja Slaninka Miceska2, Mirjana Shosholcheva3, Biljana Kuzmanovska1, Andrijan Kartalov1, MajaMojsova-Mijovska1, Marija Jovanovski-Srceva1, Risto Simeonov4, Nikola Brzanov1
Affiliation
1University Clinic for Traumatology, Orthopedic disease, Anesthesiology, Reanimation and Intensive Care Medicine and Emergency department, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, R. Macedonia
2Department of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, R. Macedonia
3University Clinic for General Surgery “St. NaumOhridski” Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, R. Macedonia
4University Clinic for Pediatric Surgery, Faculty of Medicine, University “Ss. Cyril and Methodius”, Skopje, R. Macedonia
Corresponding Author
Aleksandra Gavrilovska-Brzanov, University Clinic for Traumatology, Orthopedic disease, Anesthesiology, Reanimation and Intensive Care Medicine and Emergency department, Faculty of Medicine, University “Ss. Cyril and Methodius”, Bul. Jane Sandanski 84/3-14 Skopje Macedonia, Tel: 0038971 240 701; E-mail: gavrilovska.aleksandra@gmail.com
Citation
Gavrilovska-Brzanov, A., et al. Carboxyhemoglobin and Methemoglobin as Markers of Postoperative Pulmonary Complications. (2018) J Anesth Surg 5(1): 61- 67.
Copy rights
© 2018 Gavrilovska- Brzanov, A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Introduction: The inhalation of tobacco smoke can substantially raise the level of carboxyhemoglobin in the blood. Determination of the level of carboxyhemoglobin and methemoglobin can identify patients with increased risk for development of postoperative pulmonary complications.
Material and Methods: Thirty patients scheduled for elective urologic surgery under general endotracheal anesthesia were allocated in two groups (n = 15 each). The study group comprised patients who were smoking cigarettes or tobacco pipe, while the control group included non-smokers. In both group’s carboxyhemoglobin and methemoglobin levels were determined preoperatively, after preoxygenation, and one hour after completing the anesthesia. Postoperative pulmonary complications were assessed and recorded during the period of hospitalization.
Results: The average values of carboxyhemoglobin between the two groups were statistically significantly different. Postoperative carboxyhemoglobin was higher in smokers compared to control non-smokers group (p = 0.000). On the other hand, methemoglobin was higher in the control non-smokers group compared to smokers, but without statistical significance (p = 0.88). Regarding postoperative pulmonary complications, 13.3% of the patients in the control non-smokers group and 26.6% of the patients in smokers group had pulmonary complications.
Conclusion: In our sample there was a difference between the incidence rates of postoperative pulmonary complications; however, we cannot confirm the hypothesis that carboxyhemoglobin and methemoglobin can serve as predictors for postoperative pulmonary complications.