International Journal of Neurology and Brain Disorders
Following the Natural History Of A Probable Adrenoleukodystrophy Case And Literature Review
- 1Federal Fluminense University, HUAP, Neurology Department, Niterói, Rio de Janeiro, Brazil
- 2Federal Fluminense University, HUAP, Patology Department,Niterói, Rio de Janeiro, Brazil
- 3Masters Program in Science Rehbiitation, UNISUAM, Neuroscience Department, Bonsucesso, Rio de Janeiro, Brazil
Marco Orsini, Masters Program in Science Rehabitation, UNISUAM, Neuroscience Department, Bonsucesso,Rio de Janeiro, Brazil. E-mail: email@example.com
Orsini, M., et al. Following the Natural History of a Probable Adrenoleukodystrophy( 2015) Int J Neurol Brain Disord 2(2): 1- 4.
© 2015 Orsini, M. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywordsleukodystrophy; X-linked Adrenoleukodystrophy; Spastic paraparesis; Cognitive decline.
Leukodystrophies compass a wide range of genetic disorders that compromise the white matter. Some of them exhibit different phenotypes with late and slow onset. The present work reports an unusual case of probable X-Linked Adrenoleukodystrophy that could be classified in adrenomyeloneupathy, but there were no signs of adrenal insufficiency and the cognitive decline developed fast. MRI evinced classical symmetrical parieto-occipital pattern of lesion, although dosage of very long chain fatty acids was normal.