Journal of Pharmacy and PharmaceuticsJournal of Pharmacy and PharmaceuticsJournal of Pharmacy and PharmaceuticsJournal of Pharmacy and Pharmaceutics2576-3091Ommega Online PublishersNew Jersey, USA10710.15436/2377-1313.14.002Research ArticleFormulation and Evaluation of Self-Nanoemulsifying Powder of EzetimibeFormulation and Evaluation of Self-Nanoemulsifying Powder of EzetimibeShaileshT. PrajapatiShri Sarvajanik Pharmacy College Near Arvind Baug Mehsana-384001 Gujarat India Editor* E-mail: stprajapati@gmail.com
The authors have declared that no competing interests exist.
20140807201411JPSDD-14-RA-107/00213052014030720142014Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp Ezetimibe EZT is the selective cholesterol absorption inhibitor It is indicated for the treatment of primary hypercholesterolemia The current investigation was aimed to formulation and evaluation of self nanoemulsifying powder SNEP for EZT to enhance solubility and dissolution rate and this will leads to minimize the variability in absorption Solubility of drug was determined in different vehicles Pseudo ternary phase diagram generated using Acrysol EL 135 Tween 80 and Trancutol P The SNEP was prepared by adsorbing the optimized liquid SNEDDS on to Fujicalin as carrier The SNEP characterized by micromeritic properties differential scanning studies percentage transmittance emulsification time and zeta potential The optimized formulation had shown the smallest particle size less emulsification time good transmittance and good in vitro release The in vitro dissolution rate and ex vivo permeation rate of the drug from the SNEP was significantly higher than that of the plain drug and its suspension respectively 10