Letters in Health and Biological SciencesLetters in Health and Biological SciencesLetters in Health and Biological SciencesLetters in Health and Biological Sciences2475-6245Ommega Online PublishersNew Jersey, USA107010.15436/2475-6245.16.010Research ArticleSynthesis, Physicochemical and Antioxidant Properties of Some Metal(II) Complexes of Mixed Drugs, Aspirin and NicotinamideSynthesis, Physicochemical and Antioxidant Properties of Some Metal(II) Complexes of Mixed Drugs, Aspirin and NicotinamideAderojuOsowoleInorganic Chemistry unit Department of Chemistry University of Ibadan NigeriaEditor* E-mail: aderoju30@gmail.com
The authors have declared that no competing interests exist.
20163110201612LHBS-16-RA-107128082016241020162016Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp The Drugs Aspirin HL and Nicotinamide HL3 and their mixed metal II complexes were synthesized and isolated as M HL HL3 X2 where M Fe Co Ni Cu Zn X Cl- SO42- These complexes were characterized by spectroscopic techniques IR amp UV-Visible percentage metal molar conductance melting point and room temperature magnetic moment measurements The metal complexes were mostly non-electrolyte in DMSO with molar conductance values in the range 19 70 - 46 80 Omega -1cm2mol-1 Nicotinamide and Aspirin behaved as bidentate coordinating to the metal ion through their carbonyl oxygen and pyridinyl nitrogen atoms respectively as corroborated by infrared spectroscopy measurement Electronic spectra indicated that all the metal complexes adopted octahedral geometry and magnetic data revealed that the Mn II and Ni II complexes were probably dimeric while the remaining metal complexes were monomeric diamagnetic or paramagnetic In addition the antioxidant study revealed that the drugs Aspirin and Nicotinamide Vitamin B3 and their mixed metal complexes had higher antioxidant activity than Ascorbic acid the positive standard thus confirming their potentials as anticancer agents in-vitro 10