Journal of Cellular Immunology and Serum BiologyJournal of Cellular Immunology and Serum BiologyJournal of Cellular Immunology and Serum BiologyJournal of Cellular Immunology and Serum Biology2471-5891Ommega Online PublishersNew Jersey, USA118410.15436/2471-5891.17.004Research ArticleCanine Pluripotent Stem Cells: Preclinical Model for Stem Cell Based Regenerative MedicineCanine Pluripotent Stem Cells: Preclinical Model for Stem Cell Based Regenerative MedicineJiesiLuoYale Cardiovascular Research Center Section of Cardiovascular Medicine Department of Internal Medicine School of Medicine Yale University USAEditor* E-mail: jiesi.luo@yale.edu
The authors have declared that no competing interests exist.
20170301201731JCBMS-16-MRW-1184/00426102016241220162017Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. emsp emsp Due to the unique similarity to human physiology biochemistry and pathology for many diseases canine breeds have been applied to preclinical research into human medicine for several decades Since 2006 the discovery of induced pluripotent stem cell technology set the stage for the patient specific stem cell-based therapy To evaluate the safety and efficacy of this potential therapeutic strategy a growing body of studies on the generation and differentiation of canine induced pluripotent stem cells ciPSCs have been reported In this review the current progress from the ciPSCs studies will be described Additionally the unique regulatory mechanism s for pluripotency maintenance with in canine pluripotent stem cells will be discussed and compared with those in mouse and human 10