Journal of Addiction and DependenceJournal of Addiction and DependenceJournal of Addiction and DependenceJournal of Addiction and Dependence2471-061XOmmega Online PublishersNew Jersey, USA119610.15436/2471-061X-17-034Research ArticleThree high doses of buprenorphine in the treatment of prolonged and severe opium dependence: a new accessThree high doses of buprenorphine in the treatment of prolonged and severe opium dependence: a new accessJamshid AhmadiProfessor of Psychiatry Founder and Director Substance Abuse resaerch center Shiraz University of Medical SciencesEditor* E-mail: Jamshid_Ahmadi@yahoo.com
The authors have declared that no competing interests exist.
20161412201631JAD-16-RA-1196/03401112016081220162016Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp Background Heavy and prolonged opium dependence is a progressing problem in the East For the treatment of opium dependence buprenorphine can be prescribed less frequently than daily due to its long half-life Objective To administered three high doses buprenorphine instead of daily use to reduce probability of buprenorphine dependence Results The prescription of three high doses of 32 96 and 72 mg buprenorphine was tolerated conveniently Administration of high doses of buprenorphine completely improved opium withdrawal symptoms Discussion The current work indicated that few high doses of buprenorphine could be adequate and satisfactory for the improvement of heavy and prolonged opium dependence Conclusions We came to this result that administration of high dose buprenorphine looks to be convenient acceptable and tolerable More research studies should be of interest as high buprenorphine doses are getting more general clinically We concluded that three doses of 32 72 and 96 mg buprenorphine could be adequate for the improvement of severe opium use disorder 10