International Journal of Neurology and Brain DisordersInternational Journal of Neurology and Brain DisordersInternational Journal of Neurology and Brain DisordersInternational Journal of Neurology and Brain Disorders2377-1348Ommega Online PublishersNew Jersey, USA122110.15436/2377-1348.16.1221Research ArticleMRI Diagnosis in Classical Metachromatic LeukodystrophyMRI Diagnosis in Classical Metachromatic LeukodystrophyRajul RastogiDepartment of Radiodiagnosis Teerthanker Mahaveer Medical College and Research Center Moradabad U P IndiaEditor* E-mail: eesharastogi@gmail.com
The authors have declared that no competing interests exist.
20162012201641IJNBD-16-CR-122114112016151220162016Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp Metachromatic leukodystrophy MLD is a rare group of genetically-transmitted autosomal-recessive lipid-storage disorders characterised by accumulation of glycosphingolipids caused by deficiency of Arylsulfatase-A enzyme in lysosomes of cells necessary for formation of normal myelin sheath The disease can present anytime from infancy to adulthood and is characterised by progressive deterioration of motor amp neurocognitive functions with variable prognosis Though till date there is no definitive treatment cure for the disease yet bone marrow transplantation in infancy has shown to delay the progression of disease amp gene therapy in animal experiments has shown promising future making early diagnosis very imperative Diagnosis is usually suspected on magnetic resonance imaging MRI of brain and confirmed by enzyme assays Hence in this article we are describing the classical brain MRI and clinical features to make the readers aware of this uncommon but important neurological entity 10