Journal of Diabetes and ObesityJournal of Diabetes and ObesityJournal of Diabetes and ObesityJournal of Diabetes and Obesity2376-0494Ommega Online PublishersNew Jersey, USA123410.15436/2376-0494.16.1234Research ArticleEffects of Ultraviolet Blood irradiation in a Diabetes Rabbit ModelEffects of Ultraviolet Blood irradiation in a Diabetes Rabbit ModelGi-BeumKim 1Department of Pharmacology College of Veterinary Medicine Chonbuk National University Iksan Campus 79 Gobong-ro Iksan-si Jeollabuk-do 54596 Republic of Korea 2Department of Veterinary Medicine and Surgery College of Veterinary Medicine Sudan University of Science and Technology P O Box No 204 Hilat Kuku Khartoum Sudan 3Department of Veterinary Anatomy College of Veterinary Medicine Chonbuk National University Iksan Campus 79 Gobong-ro Iksan-si Jeollabuk-do 54596 Republic of Korea 4Institute of Jinan Red Ginseng 41 Hongsamhanbang-ro Jinan-eup Jinan-gun Jeonbuk 55442 Republic of Korea 5Department of Biochemistry Chonbuk National University Medical School Chonbuk National University 567 Baekje-daero deokjin-gu Jeonju-si Jeollabuk-do 54896 Republic of Korea Editor* E-mail: kgb70@jijrg.re.kr
The authors have declared that no competing interests exist.
20163012201632JDO-16-RA-123421112016261220162016Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp The purpose of this study is to evaluate the effects of ultraviolet blood irradiation on the blood when a low dose of ultraviolet C UV-C is directly irradiated to the blood in a diabetic rabbit model and to evaluate the effects on treatment for diabetes Type 1 diabetics were induced by intravenous IV injection of alloxan monohydrate 110 mg kg into New Zealand white rabbits weighing 2 - 2 5 Kg A UV-C lamp with light intensity of 4 W and wavelength of 260 nm was used to irradiate UV to the blood After 10 ml blood was collected from diabetic rabbits and UV was irradiated to the blood UV irradiated blood was transfused back to the original rabbits The ultraviolet blood irradiation UBI treatment was performed a total of 8 times We evaluated the effects of the UBI treatment on diabetes through hematological analysis before and after UBI treatment were performed Our results indicate that the reduced body weight is increased and blood glucose levels are significantly reduced after the UBI treatment is performed when compared to those prior to the UBI treatment In addition HCO3- levels and blood pH were elevated and lowered respectively Increased ALT and AST levels are reduced by 25 8 and 17 8 respectively when compared to those prior to the UBI treatment In addition CRE BUN and UA levels indicating renal functions are significantly reduced when compared to those prior to the UBI treatment In addition serum Mg2 and Ca2 concentrations are significantly increased when compared to those prior to the UBI treatment Serum K concentration is significantly reduced when compared to that prior to the UBI treatment As the results of calculating AG and osm they are significantly reduced when compare to those prior to the UBI treatment When the UBI treatment is performed in a diabetic rabbit model our results indicate that blood glucose levels are reduced Hematological analysis demonstrates that the UBI treatment is effective to alleviate the diabetes 10