International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science 2377-0619Ommega Online PublishersNew Jersey, USA12410.15436/2377-0619.15.016Research ArticleOmega-3 Fatty Acids Improve Lipid Metabolism and Inflammatory Markers in Patients with Heart Failure Undergoing Exercise TrainingOmega-3 Fatty Acids Improve Lipid Metabolism and Inflammatory Markers in Patients with Heart Failure Undergoing Exercise TrainingEdson Luiz da Silva1Post-Graduation Program in Nutrition of the Federal University of Santa Catarina Florianopolis Florianopolis-SC Brazil 2Post-Graduation Program in Science of Human Movement of the State University of Santa Catarina Florianopolis-SC Brazil 3Lipid Metabolism Laboratory Heart Institute InCor of the University of S atilde o Paulo Medical School Sao Paulo-SP Brazil 4Department of Clinical Analyses Federal University of Santa Catarina Florianopolis- SC BrazilEditor* E-mail: edson.silva@ufsc.br
The authors have declared that no competing interests exist.
20152404201521IJFNS-15-RA-12419022015170420152015Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp We hypothesize whether omega-3 n-3 polyunsaturated fatty acids PUFA supplementation may improve the lipid metabolism and inflammatory biomarkers in heart failure HF patients undergoing exercise training Sixteen male patients who were participating in a physical cardiac rehabilitation program ingested 4 8 g of fish oil daily 2 51 g of eicosapentaenoic and docosahexaenoic acids for 60 days Blood samples were collected at baseline and after 60 days of n-3 PUFA supplementation for analysis The paired Student t-test was applied to detect differences p lt 0 05 The n-3 PUFA significantly reduced the levels of triglyceride 28 9 small dense LDL- cholesterol 16 2 non-HDL-cholesterol 9 0 and TNF- alpha 17 8 after 60 days p lt 0 05 Furthermore the transfer of cholesteryl-ester to HDL increased by 23 1 p lt 0 05 In summary the n-3 PUFA supplementation improved the lipid metabolism and low-grade systemic inflammation in HF patients submitted to exercise training which may lower the risk of cardiovascular events 10