Journal of Stem Cell and Regenerative BiologyJournal of Stem Cell and Regenerative BiologyJournal of Stem Cell and Regenerative BiologyJournal of Stem Cell and Regenerative Biology2471-0598Ommega Online PublishersNew Jersey, USA144610.15436/2471-0598.17.022Research ArticleImmunomodulation by Mesenchymal Stromal Cells and Their Clinical ApplicationsImmunomodulation by Mesenchymal Stromal Cells and Their Clinical ApplicationsJoaquinCagliani 1The Feinstein Institute for Medical Research Center for Heart and Lungs Northwell Health System Manhasset NY USA 2The Elmezzi Graduate School of Molecular Medicine Northwell Health System Manhasset NY USA 3The Feinstein Institute for Medical Research Orthopedic Research Laboratory Northwell Health System Manhasset NY USA 4Transplantation of Surgery Department of Surgery Northwell Health System Manhasset NY USA 5Pancreas Disease Center Department of Surgery Northwell Health System Manhasset NY USA Editor* E-mail: jcagliani@northwell.edu
The authors have declared that no competing interests exist.
20171004201731JSRB-17-RW-144628032017030420172017Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. emsp emsp Mesenchymal stromal cells MSCs are multipotent progenitor cells that can be isolated and expanded from various sources MSCs modulate the function of immune cells including T and B lymphocytes dendritic cells and natural killer cells An understanding of the interaction between MSCs and the inflammatory microenvironment will provide critical information in revealing the precise in vivo mechanisms involved in MSCs-mediated therapeutic effects and for designing more practical protocols for the clinical use of these cells In this review we describe the current knowledge of the unique biological properties of MSCs the immunosuppressive effects on immune-competent cells and the paracrine role of soluble factors A summary of the participation of MSCs in preclinical and clinical studies in treating autoimmune diseases and other diseases is described We also discuss the current challenges of their use and their potential roles in cell therapies 10