International Journal of Cancer and Oncology International Journal of Cancer and Oncology International Journal of Cancer and Oncology International Journal of Cancer and Oncology 2377-0902Ommega Online PublishersNew Jersey, USA162910.15436/2377-0902.17.1629Research ArticleThe Impact of the Serotonin on the Cause and Treatment of CancerThe Impact of the Serotonin on the Cause and Treatment of CancerSomayeh Zaminpira 1Clinical Psychology Olom Tahghighat University Honorary Member of Young Researchers and Elite club Tehran Iran Ambassador of European Association for Cancer Research EACR England Nottingham 2Young Researchers and Elite club Central Tehran Branch Islamic Azad University Tehran Iran Honorary Board Member of Weston A Price Foundation WAPF Ambassador of European Association for Cancer Research EACR England Nottingham Editor* E-mail: banafsheh_pira@yahoo.com
The authors have declared that no competing interests exist.
20172812201751IJCO-17-RW-162902082017221220172017Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp This review article goes through many researches based on the effectiveness of the neurotransmitter serotonin on cancer cells and also the impact of SSRIs selective serotonin reuptake inhibitors drugs on the cause of certain types of cancers Serotonin has been shown to be a mutagenic factor for a wide range of normal and tumor cells Serotonin exhibits a growth stimulatory effect in aggressive cancers and carcinoids usually through 5- HT1 and 5-HT2 receptors In contrast low doses of serotonin can inhibit tumor growth via the decrease of blood supply to the tumor suggesting that the role of serotonin on tumor growth is concentration-dependent Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder adenocarcinoma of the prostate and renal cell carcinoma The mechanism that connect serotonin with tumor evolution seem to be related to the serotonin impact on tumor associated macrophages 10