International Journal of Cancer and Oncology International Journal of Cancer and Oncology International Journal of Cancer and Oncology International Journal of Cancer and Oncology 2377-0902Ommega Online PublishersNew Jersey, USA170310.15436/2377-0902.17.1703Research ArticleHyperleukocytosis in Metastatic Solid Tumors, A Benign Paraneoplastic Syndrome of Poor Prognosis: Short Review of LiteratureHyperleukocytosis in Metastatic Solid Tumors, A Benign Paraneoplastic Syndrome of Poor Prognosis: Short Review of LiteratureGeorgesEl HachemDepartment of Medical Oncology and Hematology Institut Jules Bordet Brussels BelgiumEditor* E-mail: george.el.hashem@hotmail.com
The authors have declared that no competing interests exist.
20170712201742IJCO-17-RW-170304102017281120172017Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp Leukemoid reaction describes an important leukocytosis more than 50 000 white blood cells mm sup3 with increased early neutrophil precursors It is secondary to a physiologic stimulation of the bone marrow in most of the cases It is called paraneoplastic when it is the consequence of cytokine storm induced by malignant processes Many solid tumors have been associated with paraneoplastic leukocytosis in the literature The elevated white blood cells WBC count is a benign process by itself but it is associated with bad prognosis and dramatic evolution of the underlying neoplasms After reviewing the literature concerning the Paraneoplastic Leukemoid Reaction PLR case reports and small case series I am writing a small review in order to increase the clinicians rsquo awareness about this rare but serious condition It is considered an indirect marker of poor outcome 10