International Journal of Neurology and Brain DisordersInternational Journal of Neurology and Brain DisordersInternational Journal of Neurology and Brain DisordersInternational Journal of Neurology and Brain Disorders2377-1348Ommega Online PublishersNew Jersey, USA197810.15436/2377-1348.18.1978Research ArticleThe Relationship between Expression of HS3ST2 and the Invasiveness in Growth Hormone AdenomasThe Relationship between Expression of HS3ST2 and the Invasiveness in Growth Hormone AdenomasZhiquanJiangDepartment of Neurosurgery the First Affiliated Hospital Bengbu Medical College Bengbu Anhui ChinaEditor* E-mail: bbjiangzhq@163.com
The authors have declared that no competing interests exist.
20181810201851IJNBD-18-RA-197826092018121020182018Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Growth hormone pituity adenomas account for about 10 - 15 of all benign pituitary tumors over-secreted growth hormone leads to acromegaly significantly increased incidence of respiratory cardiovascular and malignant tumors severely affected people rsquo s health But the pathogenesis of GH adenomas is complex it is not completely understood so far Gene HS3ST2 is one kind of sulfonyl transferase which is inactivated by hypermethylation of the gene in most tumors However the expression and role of the gene HS3ST2 in pituitary adenomas have not been reported in the literature It was found that the gene was highly expressed in GH adenoma and interacted with WNT pathway and ECM- receptor Therefore gene HS3ST2 may be the key gene for the occurrence and development of GH adenoma The purpose of this study was to investigate the difference of gene HS3ST2 expression between invasive and noninvasive growth hormone pituitary adenomas to explore the role of the gene in GH adenomas Methods Collected specimens of normal pituitary tissues n 3 and invasive and non invasive pituitary growth hormone adenoma n 6 in each group according to the inclusion and exclusion criteria the application of RT-qPCR method and Western Blot to detect the expression of gene HS3ST2 between normal pituitary tissues group and GH adenoma group Results The level of gene HS3ST2 expression in GH adenomas non-invasive and invasive and normal pituity tissues is different We found that the expression of HS3ST2 in tumor tissues was higher than that in normal pituitary tissues P lt 0 05 and the expression in noninvasive growth hormone pituitary adenomas was higher than that in invasive GH pituitary adenomas P lt 0 05 Conclusion Gene HS3ST2 may be related to the pathogenesis of growth hormone pituitary adenoma but to some extent We are not sure that the gene HS3ST2 is the key gene to promote the invasiveness of GH adenoma Further research is needed on the pathogenesis of GH adenoma and the factors related to its invasiveness 10