Journal of Pharmacy and PharmaceuticsJournal of Pharmacy and PharmaceuticsJournal of Pharmacy and PharmaceuticsJournal of Pharmacy and Pharmaceutics2576-3091Ommega Online PublishersNew Jersey, USA200810.15436/2377-1313.18.2008Research ArticlePiperidine Containing Murrayanine-Chalcones as Emerging Bactericidal and Fungicidal AgentsPiperidine Containing Murrayanine-Chalcones as Emerging Bactericidal and Fungicidal AgentsDebarshi Kar Mahapatra1 Department of Pharmaceutical Chemistry Dadasaheb Balpande College of Pharmacy Nagpur 440037 Maharashtra India2 Department of Pharmaceutical Chemistry Kamla Nehru College of Pharmacy Nagpur 441108 Maharashtra India3 Department of Chemistry Government Degree College Bijbehara 192124 Jammu and Kashmir IndiaEditor* E-mail: dkmbsp@gmail.com
The authors have declared that no competing interests exist.
20181111201852JPP-18-RA-200828102018061120182018Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp Among the 20 other alkaloid molecules murrayanine is the highest explored alkaloidal component present in the curry plant Murraya koenigii L In the current research a piperidine containing chalcone E -1- 1-methoxy-9H-carbazol-3-yl -3- 4- piperidin-1-yl phenyl prop-2-en-1-one was rationally developed by incorporating the natural portion murrayanine in the A-ring and a synthetic component 1- 4- piperidin-1-yl phenyl ethanone a piperidine containing acetophenone in the B-ring and screened against two bacterial species Escherichia coli and Staphylococcus aureus and two fungal species Candida albicans and Aspergillus niger The chalcone 1 3-diphenyl-2E-propene-1-one candidate expressed a better anti-bacterial activity than that of anti-fungal activity The chalcone displayed the highest activity against E coli followed by S aureus and lowest against C albicans Although were found to have less activity and potency than that of the standard compounds ciprofloxacin and fluconazole The current study will open new avenues of research on hybrid heterocyclic chalcones and will motivate researchers to further developing highly active compounds based on benzylideneacetophenone scaffold 10