Journal of Gastrointestinal Disorders and Liver functionJournal of Gastrointestinal Disorders and Liver functionJournal of Gastrointestinal Disorders and Liver functionJournal of Gastrointestinal Disorders and Liver function2471-0601Ommega Online PublishersNew Jersey, USAResearch ArticleResection of colorectal liver metastases: A matched case-control study evaluating perioperative chemotherapyResection of colorectal liver metastases: A matched case-control study evaluating perioperative chemotherapyNinaWeiler1Universit auml tsklinikum Frankfurt Medizinische Klinik 1 Theodor-Stern-Kai 7 60590 Frankfurt am Main Deutschland 2Universit auml tsklinikum Frankfurt Allgemein- und Viszeralchirurgie Theodor-Stern-Kai 7 60590 Frankfurt am Main Deutschland 3Universit auml tsmedizin Mainz Klinik f uuml r Allgemein- Viszeral- und Transplantationschirurgie Abteilung f uuml r Transplantationschirurgie Langenbeckstrasse 1 55131 Mainz Deutschland 4Universit auml tsklinikum Frankfurt Institut f uuml r Biostatistik und Mathematische Modellierung Theodor-Stern-Kai 7 60590 Frankfurt am Main Deutschland 5Universit auml tsmedizin Mainz I Medizinische Klinik Langenbeckstrasse 1 55131 Mainz DeutschlandEditor* E-mail: nina.weiler@kgu.de
The authors have declared that no competing interests exist.
20190605201951JGDLF-19-RA-248822042019010520192019Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background Colon carcinoma is one of the most frequently occurring cancers worldwide with a high proportion of patients developing liver metastases The efficacy of perioperative chemotherapy remains controversial nbsp Methods Long-term outcomes of patients who underwent liver resection for colorectal liver metastases between September 1997 and May 2012 with and without perioperative chemotherapy were assessed The influence of chemotherapy and other prognostic factors on survival were evaluated by conducting a matched case-control study nbsp Results Perioperative chemotherapy did not improve progression-free or overall survival Overall survival was significantly influenced by node-positivity of the primary tumour whereas progression-free survival was influenced by node-positivity of the primary tumour spread in both liver lobes and the R status of liver resection In the Cox proportional hazards model node-positivity of the primary tumour was the sole prognostic factor for overall survival in the long-term follow-up of patients with colorectal liver metastases nbsp Conclusion Perioperative chemotherapy did not improve long-term outcomes after the resection of colorectal liver metastases which is in concordance with previous data for short-term follow-up 10