Journal of Dentistry and Oral CareJournal of Dentistry and Oral CareJournal of Dentistry and Oral CareJournal of Dentistry and Oral Care2379-1705Ommega Online PublishersNew Jersey, USA251210.15436/2379-1705.19.2512Research ArticleEvaluation of the Correlation between Tryptase Positive Mast Cells and Chronic Periodontitis using ImmunohistochemistryEvaluation of the Correlation between Tryptase Positive Mast Cells and Chronic Periodontitis using ImmunohistochemistryShirinModabbernia1Department of Periodontics Faculty of Dentistry Guilan University of Medical Sciences Iran 2Department of Oral amp Maxillofacial Pathology Faculty of Dentistry Guilan University of Medical Sciences IranEditor* E-mail: shirinmodabbernia@yahoo.com
The authors have declared that no competing interests exist.
20192210201951JDOC-RA-19-251202062019181020192019Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background Mast cells are mobile bone-marrow-derived granule-containing immune cells that are found in all connective tissues and mucosal environments Mast cells are able to phagocytosis process and present antigens as effectively as macrophages Bacterial plaque has been implicated as the primary etiologic factor in inflammatory periodontal disease but several studies have recently focused on the role of the immune system cells in periodontal disease nbsp Aim The aim of the present study was to determine the relationship between tryptasepositive mast cells and chronic periodontal disease nbsp Methods Seven cases of smoker chronic periodontitis seven cases of nonsmoker chronic periodontitis seven cases of smoker clinically healthy gingival tissues and seven cases if nonsmoker clinically healthy gingival tissues were obtained from patient undergoing periodontal surgery in Rasht private dental clinics Samples fixed in 10 buffered formalin and stained with tryptase stain and observed under optical microscope nbsp Results There is no significant difference between tryptase positive mast cells and chronicperiodontitis P 0 829 However a significant difference was seen between the number of tryptase positive mast cells in chronic periodontitis and non-smoker chronic periodontitis P 0 012 similar to those in chronic periodontitis with systemic disease and chronic periodontitiswithout it P 0 006 nbsp Conclusion considering the above findings which are in contrast withsimilar studies more extensive studies with more precise methods are recommended in order to clarify the role of these mast cells in the pathogenesis of chronic periodontitis 10