Journal of Diabetes and ObesityJournal of Diabetes and ObesityJournal of Diabetes and ObesityJournal of Diabetes and Obesity2376-0494Ommega Online PublishersNew Jersey, USA265910.15436/2376-0494.20.2659Research ArticleComparison of the kinetics of glucose response after oral glucose tolerance test and a standardised breakfast in obese patients with the use of cgmComparison of the kinetics of glucose response after oral glucose tolerance test and a standardised breakfast in obese patients with the use of cgmMarinos FysekidisDepartment of Endocrinology Diabetology Nutrition JeanVerdier Hospital AP-HP CRNH-IdF CINFO Paris Nord University Bondy FranceEditor* E-mail: fisekidis_marinos@hotmail.com
The authors have declared that no competing interests exist.
20202102202061JDO-20-RA-265902022020180220202020Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background The oral glucose tolerance test OGTT is the reference method for classification of hyperglycemia Standardized meals bear resemblance to physiological nutrient ingestion The aim of the present study was to study with the use of continuous glucose monitoring CGM the glucose curve after standardized breakfast and determine if glucose kinetics were comparable to an OGTT nbsp Methods Seventy-two obese subjects without known hyperglycemia were included A blinded CGM device was placed at least 2 hours before the OGTT Fifty-five participants accepted to receive a standardised breakfast providing 75 grams of carbohydrates Subjects were classified as normoglycemic NGT n 25 impaired fasting glucose or impaired glucose tolerance IFG IGT n 21 and type 2 diabetic T2D n 9 according to OGTT nbsp Results For all55 participants the 120-minute Area under the Curve for glucose AUC after OGTT and standardised breakfast was similar 977 plusmn 257 vs 931 plusmn 238 mmol min L p 0 075 Both AUCs were highly correlated R sup2 0 504 p lt 0 001 The time to the glucose peak was longer after OGTT than after breakfast 70 1 plusmn 30 8 vs 59 3 plusmn 22 4 min respectively p 0 020 and specifically in IGT p 0 003 and T2D p 0 037 but not in NGT patients p 0 939 Interstitial glucose levels at 120 minutes were higher after OGTT than after breakfast 8 2 plusmn 2 5 vs 6 8 plusmn 2 0 mmol L p lt 0 001 and differed according to glycemic status interaction p 0 022 nbsp Conclusions The use of CGM for the study of glucose response curve after a standardized breakfast can provide valuable information closer to real life conditions Further studies validating reproducibility and adjusting for the values of interstitial glucose are necessary 10