International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science 2377-0619Ommega Online PublishersNew Jersey, USA39210.15436/2377-0619.15.022Research ArticleProtective effect of Lyciumbarbarum extract as Antioxidant Agent on Roridin A Induced Hepatotoxicity in Male RatProtective effect of Lyciumbarbarum extract as Antioxidant Agent on Roridin A Induced Hepatotoxicity in Male RatNagwa M. Elsawi 1Department of Chemistry Faculty of Science Sohag University Sohag Egypt 2Department of Biochemistry Faculty of Science King Abdel-Aziz University Jaddah Saudi Arabia 3Department of Pharmacology Faculty of Medicine Sohag University Sohag Egypt 4Department of Histology Faculty of Medicine Sohag University Sohag Egypt Editor* E-mail: elsawinagwa@yahoo.com
The authors have declared that no competing interests exist.
20153107201522IJFNS-15-RA-39217052015280720152015Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp The fruit goji berry of Lyciumbarbarym a traditional Chinese herbal medicine has been widely used in healthy diets due to its potential role in the prevention of chronic diseases We studied the effects ofroridin A toxin in male rat liver and their amelioration by goji extract Thirtymale adult albino rats were divided into three groups 10 rats each Group 1 Control group was given only the solvent DMSO of roridin A Group 2 was administered a single dose 0 6 mg kg of rordin A mycotoxin dissolved in 1 DMSO for one week Group 3 was treated prophylactically with goji extract 5 mg kg using gastric tube daily for 6 days and left for one week Roridin A showed a highly significant increase in serum levels of cholesterol triglycerides and significant increase inglucose total antioxidants and tumor necrosis factor TNF There was significant decrease in serum ferritin level On the other hand administration of goji along with rordin A showed a reduction in the above mentioned factors and elevation inferritin level Histopathological changes in the rat liver coincided with the above biochemical changes In conclusion the treatment of rats with goji extract ameliorated the adverse effects of rordin A Thus gojimay be used asan antioxidant for certain toxins 10