Journal of Cellular Immunology and Serum BiologyJournal of Cellular Immunology and Serum BiologyJournal of Cellular Immunology and Serum BiologyJournal of Cellular Immunology and Serum Biology2471-5891Ommega Online PublishersNew Jersey, USA46710.15436/2471-5891.15.467Research ArticleIs Seronegative Spondyloarthritides (SSA) Truly Seronegative? IgG -Rheumatoid Factor, Anti-Nuclear Ab, and Anticardiolipin Ab can be Positive in SSA alsoIs Seronegative Spondyloarthritides (SSA) Truly Seronegative? IgG -Rheumatoid Factor, Anti-Nuclear Ab, and Anticardiolipin Ab can be Positive in SSA alsoNiladriChaudhry 1Department of Pathology Institute of Medical Science Banaras Hindu University Varanasi India 2Department of Medicine Institute of Medical Science Banaras Hindu University Varanasi India 3Department of Orthopaedics Institute of Medical Science Banaras Hindu University Varanasi India Editor* E-mail: niladri0225@gmail.com
The authors have declared that no competing interests exist.
20152212201511JISB-15-RW-46706082015191220152015Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp Background Seronegative Spondyloarthritides is a very common problem in our area Etiopathogenesis of the disease is not clear Rheumatoid arthritis factor RA factor and anti CCP antibody which are diagnostic marker of RA are absent in Seronegative Spondyloarthritides Hence it is called Seronegative Aim of the present study is to see some autoantibodies of RA and SLE in SSA patients Method HLA B27 was done by PCR SSP method Only HLA B27 positive cases were taken IgM RF IgA RF IgG RF anti CCP antibodies ANA ds DNA were done by ELISA technique Total 90 cases of SSA and 43 healthy control cases were studied within a period of 1 years Result IgM RF IgA RF and IgG RF was positive in 5 5 8 9 and 37 8 cases of SSA respectively while in control only 4 7 were IgA RF positive and 18 6 were IgG RF positive Anticyclic citrullinated peptide CCP Abs were not detected in healthy control but it was positive in 11 11 cases of SSA All these patients had polyarthritis ANA and ds DNA was positive in 13 3 and 7 8 cases of SSA respectively Taking together 5 6 were positive for both ANA and ds DNA Conclusion Although clinically none of the patients had feature of SLE Positivity of IgG RF and ANA was statistically significant Anticardiolipin Ab ACLA was positive in 15 6 of SSA and 11 6 cases of control cases which was non significant Thus our study concludes that SSA also have autoimmune basis 10