Journal of Diabetes and ObesityJournal of Diabetes and ObesityJournal of Diabetes and ObesityJournal of Diabetes and Obesity2376-0494Ommega Online PublishersNew Jersey, USA86410.15436/2376-0494.16.864Research ArticleHerbal Anti-Hyperglycemic Compound Improves Glycemic Control and Insulin Sensitivity in Diabetic RatsHerbal Anti-Hyperglycemic Compound Improves Glycemic Control and Insulin Sensitivity in Diabetic RatsSuman BalaSharma 1Department of Biochemistry University College of Medical Sciences University of Delhi Dilshad Garden Delhi India 2Department of Pathology University College of Medical Sciences University of Delhi Dilshad Garden Delhi India 3Department of Biochemistry All India institute of Medical Sciences Ansari Nagar New Delhi Editor* E-mail: drsbs08@hotmail.com
The authors have declared that no competing interests exist.
20160607201631JDO-16-RA-86413042016300620162016Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp Objective To study the effect of HPLC purified herbal anti-hyperglycemic active compound FIIc isolated from the fruit pulp of Eugenia jambolana in diabetic rats Methods 24 male wistar rats were taken and diabetes was induced in group B C and D rats n 6 each by injecting Streptozotocin at a dose of 45 mg kg of body weight 15 minutes after Nicotinamide at a dose 230 mg kg body weight intraperitoneally after overnight fasting Active compound FIIc was given to group C and Pioglitazone to group D at dose of 20 mg kg of body weight orally for 4 weeks respectively Glycemic and lipid profile protein tyrosine kinase activity and serum DPP-4 levels were measured and compared between all the 4 study groups Results Significant Improvement in body weight glycemic profile dyslipidemia and tyrosine kinase activity 4 90 plusmn 1 28 U mg protein were observed in FIIc treated rats at week 4 of the study compared to diabetic control rats Serum DPP-4 levels 26 41 plusmn 0 43 pg ml were also found to be decreased in FIIc treated rats at week 4 of the study compared to diabetic control rats This is possibly due to increased serum insulin levels and increased insulin sensitivity after treatment with active compound FIIc Conclusion FIIc significantly reduced hyperglycemia and dyslipidemia by inhibiting DPP-4 levels and improves insulin sensitivity by increasing protein tyrosine kinase activity and serum insulin levels 10