International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science International Journal of Food and Nutritional Science 2377-0619Ommega Online PublishersNew Jersey, USA98510.15436/2377-0619.16.985Research ArticleEffect of Four Different Meal Types on Postprandial Oxidative Stress: A Randomized Crossover Study with Healthy SubjectsEffect of Four Different Meal Types on Postprandial Oxidative Stress: A Randomized Crossover Study with Healthy SubjectsRuthChan 1The Chinese University of Hong Kong Hong Kong 1The Hong Kong Polytechnic University Hong Kong Editor* E-mail: ruthchansm@cuhk.edu.hk
The authors have declared that no competing interests exist.
20160508201632IJFNS-16-RA-98523062016010820162016Creative Commons Attribution LicenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. nbsp emsp emsp Diet is one factor influencing postprandial oxidative stress POS Previous trials mainly used artificial meals to examine the effect of diet on POS which could give results that are not representative of the real life postprandial situation This study evaluated the acute effect of four distinct real-life meal types on POS Thirty three heathy non-obese adults were randomized to receive one of the tested meals capturing distinct features of meals of Cantonese Northern Chinese South Indian and American in a series of four one-day studies Fasting two four and six hours postprandial responses of biomarkers of oxidative stress plasma glucose lipids and high-sensitivity C-reactive protein hsCRP were measured Mean plasma allantoin concentration significantly increased for all meals at two-hours after ingestion levels peaked at four-hours and declined by 6-hours post-ingestion though baseline levels regained only with the Cantonese meal The magnitude of postprandial increase in plasma allantoin concentration was smallest with the Cantonese meal and greatest with the American meal These was less marked differences in postprandial changes in urine F2-isoprostanes F2-IsoPs across meals but urine F2-isoPs concentrations significantly increased for each meal during the six-hour postprandial period There were differential meal effects on the postprandial changes in plasma glucose and triglyceride concentrations Postprandial triglyceride levels significantly increased for all meals except for the Cantonese meal Plasma hsCRP did not change with time or meal type Our study demonstrates significant differential acute effects of four distinct meal types on POS in healthy adults 10