Serafim  Papadimitriou

Pranab Kumar Das



Dr.Pranab Kumar Das is Honrary Sr. Research Fellow, University of Birminham, UK; Honorary Research and Teaching Associate, Dept. Of Pathology, Academic Medical Center-University of Amstedam(AMC-UVA), Netherlands; Guest Professor, Institute Lauro Souza Lima, Bauru, Brazil and Chair of Infmmune deficiency-inflammation, Inst. Pediatrica, University of Brescia Italy.Pranab kumar has Good number of publications.


Area of Interest

1)Infection (leprosy-mycobacterial infection)
2)Immunity (autoimmunity and Idiopathic disease)
4)Experimental models to study Tissue specific Immunopathology.

top publication

1. Das PK and Liddell J (1970): Purification and properties of human cholinesterase. Biochem J 116, 875 881

2. Das PK, Bray GM, Aguayo A and Rasminsky M (1976): Diminished ouabain sensitive sodium potassium ATPase activity in sciatic nerves of rats with Streptozotocin induced diabetes. Exptl Neurol 53, 285 287

3. Huikeshoven H, Landheer J, Leiker DL, Das PK, Goldring OL and Pondam KW (1978): \"Demonstration of dapsone in urine and in serum by ELISA inhibition\". Lancet 1, 200 202. 4. Das PK, Klatser PL, Pondam KW, Huikeshoven H, Landheer J, Leiker DL and Rees RWJ (1980): Dapsone and an¬¬ti dapsone antibody in circulating immunocomplexes in Leprosy pa¬tients\'sera. Lancet 1, 1309 1312.

5. Iskander R, Das PK and Aalberse RC (1981): IgG4 anti¬bodies in Egyptian patients with schistosomiasis. Int Arch Allergy Appl Immunol 66, 200 207

6. Wright EP, Gutherie CD, Salim D, Hilditch JO and Das PK (1982): Inhibition of lymphocyte activation by the hatching fluid from Schistosoma mansoni eggs. Infect Immun 36, 419 422.

7. Thole JER, Dauwerse HG, Das PK, Groothuis DG, Schould LM and Van Embden JDA (1985): Cloning of Mycobacterium bovis BCG and expression of antigens in Esche-richia Coli. Infect Immun 50, 800 806

8. Rozemond RC, Halperin M and Das PK (1985): Inhibition of natural killer cell mediated cytotoxicity by lipids extracted from Mycobacterium bovis BCG. Clin Exp Immunol 62, 482 49¬0.

9 Bos JD, Zonneveld I, Das PK, Krieg SR, van der Loos C and Kapsenberg ML (1987): Distribution and immunophenotypic character of lymphocyte subpopulations in normal human skin. J Invest Dermatol 88, 569 573.

10. Van den Brink W, Van der Loos C, Volkers H, Lauwen R, Van den Berg F, Houthoff HJ and Das PK (1989): Combined β galactosidase and immunogold/silver staining for imunohistochemistry and DNA in situ hybridisation. J. Histochem.Cytochem. 38, 325 329.

11. Bos JD, Teunissen MBM, Cairo I, Krieg SR, Kapsenberg ML, Das PK and Borst J (1990): T cell receptor bearing cells in normal human skin; J Inv Dermatol, 94, 37-42.

12 Das PK, Rambukkana A, Baas JG, Groothuis DG and Halpe¬rin Moshe (1990): Enzy-me linked Immunosorbent Assay for Distinguishing Serological Responses of Leproma-tous and Tuberculoid Leprosies to the 29/33 KDa Doublet and 64 KDa Antigens of Mycobacterium tuberculosis. J. Clin. Microbiol. 28, 379 382.

13. Best AC, Das PK, Patel HRH and Van Noorden CJF (1990): Quantitative cytochemical detection of malignant and potentially cancerous cells in the colon, Cancer Res, 50, 5112 51¬18.

14. Blaauwgeers JLG, Mulder CJJ, Das PK, Haagsma J and Tytgat GNJ (1990): Crohn\'s Disease, A Mycobacterial aetiology? Eur. J. Gastroenterol Hepatol 2, 237 240.

15. Wehmeyer A, Das PK, Swaak T, Wouters G and Kijlstra A (1991):Sjogren syndrome: comparitive studies in local ocular and serum immunoglobulin concentrations with special reference to Secretory IgA; International Opthalmol. 15, 147 151.

16. Van der Wal AC, Das PK, Tigges AJ and Becker AE (1992): Macrophage differentiation in atherosclerosis: An in situ Immunohistochemical analysis inhermans; Am. J. Pathol. 141, 161 168.

17. Rambukkana A, Das PK, Krieg S and Faber WR (1992): Associationof the mycobacterial 30 kDa region proteins with the cutaneous infiltrates of leprosy lesions: Evidence for the role of major mycobacterial secreted proteins in the local tissue immune response of leprosy. Scand. J. Immunol. 36, 35 48.

18. Rambukkana A, Das PK, Faber WR, Burggraaf JD, Yong S, Thole JER and Harbor M(1992).: Heterogeneity of monoclonal antibody reactive epitopes on mycobacterial 30 KDa region protein and the secreted antigen complex: in situ demonstrati¬on of the antigen 85B on mycobacterium leprae cell wall surface; Infect Immun, 60, 5172¬ 5181

19. Rambukkana A, Das PK, Faber WR, Burggraaf JD, Teeling P, Krieg S and Harboe M (1993): The mycobacterial secreted antigen 85B complex possess epitopes that are diffe¬rentially expressed in human leprosy lesions and my¬cobacterium leprae cell wall surface; Infect Immun, 61, 1835 1845.

20. Le Poole IC, Wijngaard van den RMJGJ, Westerhof W, Verkruisen RP, Dutrieux RP, Dingemans KP and Das PK (1993): Phagocytosis by normal human melanocytes in vitro; Exptl. Cell Res.205, 388 395

21. Leenstra S, Troost D, Das PK, Claessen N, Bosch A and Becker AE (1993): Endothelial Cell marker PAL-E reactivity to brain tumour, developing brain and brain disease; Cancer 72, 3061 3067.

22. Le Poole IC, Mutis T, Van den Wijngaard RMGJ, Westerhof W, Ottenhof T, De Vries R and Das PK (1993): A novel antigen presen¬ting function of melanocytes and its possible relationship to hypopigmentary disorders; J Immunol.151, 7284 7292.

23. Van der Wal AC, Becker AE, Van der Loos CM and Das PK (1993): Medial thinning and atherosclerosis, evidence for involvement of a local inflammatory process; Atherosclerosis 103, 55 64.

24. Van der Wal AC, Becker AE, Van der Loos CM and Das PK (1994): Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterised by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89, 36 44.

25. De Boer OJ, Horst E, Verhagen C, Bos JD, Pals ST and Das PK (1994): Functional evidence that the HECA 452 antigen is involved in the adhesiom of human neutro-phils and lymphocytes to TNF α stimulated endothelial cells; Immunology, 81, 359-365

26. Leenstra S, Das PK, Troost D, De Boer OJ, Bosch DA(1994):Human malignantastrocytes express macrophage phenotype; J.Neuro Immunol.56,17-26.

27. Kreuzpaintner K, Das PK, Stronkhorst A, Slob AW and Strohmeyer G (1995); Effect of intestinal resection on serum antibodies to the mycobacterial 45/4 kilodalton doublet antigen in Crohn’s disease; GUT,37,361-366.

28.Pistoor F, Rambukkana A, Kapsenberg ML, Bos JD and Das PK (1996): A novel predictive assay for contact allergens using human explant cultures; Amer.J.Pathol.149, 337-349.

29.Ivanova K, Le Poole IC, Gerzer R, Westerhof W and Das PK (1997): Effects on nitric oxide on the adhesion of human melanocytes to extracellular matrix components; J.Pathol. 183(4), 469-476.

30.Verhagen CE, Wierenga EA, Buffing AAM, Chand MA, Faber WR and Das PK (1997): Reversal reaction in borderline leprosy is associated with a polarised shift to Type-1 like mycobacterium leprae T cell reactivity in lesional skin: a follow up study; J.Immunol.159, 4474-4483.

31 Das Pranab Kumar, van Es Remco and Houthoff Hendrik Jan (1998). Method and device for identifying a mycobacterium species responsible for mycobacterial infection; Patent No.5,817,473, Int.Cl.GOIN 33/53, Us Cl 435.32: PCT Pub. No. Wo94/14069

32. Verhagen CE, Van der Pouw Kraan CTM, Buffing AAM, Chand MA, Faber WR, Aarden LA and Das PK (1998). Type-1 and Type-2 like lesional skin derived M.leprae responsive T cell clones are characterised by co-expression of IFN-γ/ TNF-α and IL-4/IL- 5/IL-13 cytokines respectively; J.Immunol.160, 2380-2387.

33. Camoglio L, Te Velde AA, Tigges AJ, Das PK and Van Deventer SJH (1998): Altered expression of Interferon-γ and Interleukin-4 in inflammatory bowel disease; Inflammatory Bowel Diseases 4, 285-290.

34 Verhagen CE, Faber WR, Klatser P, Buffing AAM, Naafs B and Das PK (1999). Immunohistological analysis of in situ expression of mycobacterial antigens in skin lesions of leprosy patients across the histological spectrum; Amer.J.Pathol., 154; 1793- 1804.

35 Meije CB, Mooi WJ, Le Poole IC, Van Muijen GNP and Das PK (2000): Micro anatomy related antigen expression in melanocytic lesions; J.Pathol.90, 572-578.

36 Peizong Yang, Das Pranab K and Kijlstra Aize (2000): Localisation and Characterisation of Immunocompetent Cells in the Human Retina; Occular Immunol.8, 149-157.

37 Das Pranab K, Van den Wijngaard René MJGJ, Wankowicz-Kalinska Anna and Le Poole I.Caroline (2001): A symbiotic concept of autoimmunity and tumour immunity: Lessons from vitiligo; Trends in Immunol. 22, 130-136.

38 Meije Clifton B, Hakvoort Theodorus BM, Swart Guido WM, Westerhof Wiete, Lamers Wouter H and Das Pranab K (2002): Gene expression patterns in melanocytic cells: Candidate markers for early stage and malignant transformation; J. Pathol.,196;51-58 39 Vanndeputte Dimitri AA, Troost Dirk, Leenstra Sieger, IJlst-Keizers Helen, Ramkema Marja, Bosch D. Andries, Baas Frank, Das (Pra)nab K and Aronica Eleonora (2002): Overexpression of Id proteins in human astrocytomas and reactive astrocytes; Glia, 38,329-338.

40 Rustemeyer Thomas, Rustemeyer Michaela, Von Bloembergen B. Marry E, Frosch Peter J, Das Pranab K and Scheper RKJ (2002): Comparison of two in vitro dendritic cell maturation models for screening contact sensitizers using a panel of methacrylates; Exp.Dermatology,12: 682-691

41 Fontana Stefania, Moratto Daniiele, Mangal Surinder , De Francesco Maria, Vermi William, Ferrarai Simona, Fachetti Fabio, Kutukculer Necil, Claudia Fiorini, Duse Marzia, Das Pranab K., Notarangelo Luigi, Plebani Alessandro and Badolato Raffele (2003): Functional defects of dendritic cells in patients with CD40 deficiency. Blood, 102: 4099-4106;

42. Das PK, van ES RM and Houthoff HJ (2004):Methods and device for identifying mycobacterium speciesResponsible for a mycobacterial infection; United States Patent US 6,416,962 B1 page 1-18.

43 Lehe CL, Jacobs JL., Hua Mei C, Courtellemont P, Elliott GR and Das PK (2006) Subtoxic concentrations of allergenic haptens induce LC migration and maturation in a human organotypic skin explant culture model: A novel method for identifying potential contact allergens; Experimental Dermatol. 15:421-431.