Serafim  Papadimitriou

Rosanna Papa



Rosanna Papa received the BSc in Chemistry (2002) and PhD degree in Biotechnological Science (2006) at Federico II University in Naples (Italy). In 2004 she had a fellowship at Ernst Moritz Arndt University of Greifswald (Germany). Starting from 2007 she worked at Sapienza University in Rome (Italy) in the Department of Public Health and Infectious Diseases as microbiologist. She is also working as teaching assistant/graduate scholar.
Actually her research interests are the study of molecular mechanisms of biofilm formation in Gram positive and Gram negative bacteria and the research of new anti-infective molecules active against biofilm forming bacteria.
She has published more than 25 peer reviewed research articles and more than 100 peer reviewed posters and oral presentation in various national and international conferences.


Area of Interest

Mechanism of disulphide bonds formation in cold-adapted bacteria and characterization of periplasmic oxidative enzymes.
Regulation of gene expression in cold adapted bacteria in response to different nutritional conditions.
Construction and optimization of inducible expression systems in cold adapted bacteria for production of recombinant proteins.
Aromatic compounds and model wastewater degradation and detoxification in cold adapted bacteria.
Research of new genes coding for laccase in basidiomycete fungi and new laccase-like enzymatic activities in bacteria.
Study of molecular mechanism of biofilm formation in Gram positive and Gram negative bacteria.
Research of new molecules with anti-infective properties active against biofilm forming Gram positive bacteria.

top publication

1. Madonna S, Papa R, Birolo L, Autore F, Doti N, Marino G, Quemeneur E, Sannia G, Tutino ML, Duilio A. (2006) The thiol-disulfide oxidoreductase system in the coldad apted bacterium Pseudoalteromonas haloplanktis TAC125: discovery of a novel disulfide oxidoreductase enzyme. Extremophiles. 10: 41-51.

2. R. Papa, V. Rippa, G. Sannia, G. Marino and A. Duilio (2006) Recombinant protein expression system in cold loving microorganisms. Microbial Cell Factories 5: S37.

3. R. Papa, S. Glagla, A. Danchin, T. Schweder, G. Marino, A. Duilio (2006) Proteomic identification of a two-component regulatory system in Pseudoalteromonas haloplanktis TAC125 Extremophiles 10: 483-491.

4. Siani, R. Papa, A. Di Donato and G. Sannia (2006) Recombinant expression of Toluene o-Xylene Monooxygenase (ToMO) from Pseudomonas stutzeri OX1 in the marine Antarctic bacterium Pseudoalteromonas haloplanktis TAC125. Journal of Biotechnology 126: 334-341.

5. R. Papa, V. Rippa, G. Sannia, G. Marino and A. Duilio (2007) An effective cold inducible expression system developed in Pseudoalteromonas haloplanktis TAC125. Journal of Biotechnology 127: 199-210.

6. M. Artini, G. L. Scoarughi, R. Papa, G. Dolci, M. De Luca, G. Orsini, S. Pappalardo, J. W. Costerton, L. Selan (2008) Specific Anti Cross Infection Measures May Help to Prevent Viral Contamination of Dental Unit Waterlines: a pilot study. Infection 36: 467-471.

7. Selan L., Palma S., Scoarughi G.L., Papa R., Veeh RH, Di Clemente D., Artini M. (2009) Phosphorylcholine impairs susceptibility to biofilm formation of hydrogel contact lenses. American Journal of Ophthalmology 147: 134-139.

8. R. Papa, E. Parrilli and G. Sannia (2009) Engineered marine Antarctic bacterium Pseudoalteromonas haloplanktis TAC125: a promising micro-organism for the bioremediation of aromatic compounds. Journal of Applied Microbiology 106: 49–56.

9. Artini M., Papa R., Scoarughi G.L., Catalano C., Palamara A.T., Passariello R., Selan L. (2009) In Vitro Detection of Herpes Simplex Virus-1 and-2 Infection with Immunospecific Gd3+-C16-enhanced Magnetic Resonance Imaging. International Journal of Immunopathology and Pharmacology 22: 145-151.

10. R. Papa, V. Rippa and A. Duilio. (2009) Identification of the transcription factor responsible for L-malate-dependent regulation in the marine Antarctic bacterium Pseudoalteromonas haloplanktis TAC125. FEMS Microbiology Letters 295: 177–186.

11. Artini M., Scoarughi G.L., Papa R., Cellini A., Avanzolini C., Mileto E., Rizzo L., Selan L. (2010) Comparison of anti-bacterial prophylactic properties of two different grafts: action of antibacterial graft coating and systemic antibiotic treatment. International Journal of Immunopathology and Pharmacology. 23:383-386.

12. Parrilli E., Papa R., Tutino M.L., and Sannia G. (2010) Engineering of a psychrophilic bacterium for the bioremediation of aromatic compounds. Bioengineered Bugs. 1(3): 213-216.

13. Artini M, Romanò C, Manzoli L, Scoarughi GL, Papa R, Meani E, Drago L, Selan L. (2011). Staphylococcal IgM enzyme-linked immunosorbent assay for diagnosis of periprosthetic joint infections. Journal of Clinical Microbiology 49(1):423-5.

14. Artini M, Papa R, Barbato G, Scoarughi GL, Cellini A, Morazzoni P, Bombardelli E, Selan L. (2012) Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds. Bioorganic & Medicinal Chemistry 20(2):920-6

15. Artini M, Scoarughi GL, Papa R, Cellini A, Carpentieri A, Pucci P, Amoresano A, Gazzola S, Cocconcelli PS, Selan L. (2011) A new anti-infective strategy to reduce adhesion-mediated virulence in Staphylococcus aureus affecting surface proteins Int J Immunopathol Pharmacol. 24:661-72.

16. Artini M, Scoarughi G.L.; Cellini A.; Papa R; Barbato G; Selan L. (2012) Holo and apo-transferrins interfere with adherence to abiotic surfaces and with adhesion/invasion to HeLa cells in Staphylococcus spp. Biometals 25:413-21.

17. Artini M, Papa R, Scoarughi GL, Galano E, Barbato G, Pucci P, Selan L. (2013) Comparison of the action of different proteases on virulence properties related to the staphylococcal surface. J Appl Microbiol. 114:266-77.

18. Papa R, Parrilli E, Sannino F, Barbato G, Tutino ML, Artini M, Selan L. (2013) Antibiofilm activity of the Antarctic marine bacterium Pseudoalteromonas haloplanktis TAC125. Res Microbiol doi:pii: S0923-2508(13)00011-9.

19. Papa R, Artini M, Cellini A, Tilotta M, Galano E, Pucci P, Amoresano A, Selan L. (2013) A new anti-infective strategy to reduce the spreading of antibiotic resistance by the action on adhesion-mediated virulence factors in Staphylococcus aureus. Microb Pathog. 63:44-53.

20. Artini M, Papa R, Cellini A, Tilotta M, Barbato G, Koverech A, Selan L. (2014) Effect of Betamethasone in combination with antibiotics on Gram positive and Gram negative bacteria Int J Immunopathol Pharmacol.;27: 675-82.

21. Artini M, Cellini A, Scoarughi GL, Papa R, Tilotta M, Palma S, Selan L. (2015) Evaluation of contact lens multipurpose solutions on bacterial biofilm development. Eye & Contact Lens. 41: 177-82.

22. Parrilli E, Papa R, Carillo S, Tilotta M, Casillo A, Sannino F, Cellini A, Artini M, 23. Selan L, Corsaro MM, Tutino ML. (2015) Anti-biofilm activity of Pseudoalteromonas haloplanktis TAC125 against Staphylococcus epidermidis biofilm: evidences of a signal molecule involvement? Int J Immunopathol Pharmacol. 28: 104-13.

24. Artini M, Cellini A, Papa R, Tilotta M, Scoarughi GL, Gazzola S, Fontana C, Cocconcelli PS, and Selan L. (2015) Adhesive behaviour and virulence of coagulase negative staphylococci isolated from Italian cheeses. Int J Immunopathol Pharmacol. 28:341-50.

25. L Selan, R Papa, M Tilotta, G Vrenna, A Carpentieri, A Amoresano, P Pucci, M Artini. (2015) Serratiopeptidase: a well-known metalloprotease with a new nonproteolytic activity against S. aureus biofilm. BMC Microbiology 9;15(1):207.

26. Papa R, Selan L, Parrilli E, Tilotta M, Sannino F, Feller G, Tutino ML, Artini M. (2015) Anti-biofilm activities from marine cold adapted bacteria against staphylococci and Pseudomonas aeruginosa. Frontiers in Microbiology 6:1333.

27. Parrilli E, Ricciardelli A, Casillo A, Sannino F, Papa R, Tilotta M, Artini M, Selan L, Corsaro MM, Tutino ML. (2016) Large-scale biofilm cultivation of Antarctic bacterium Pseudoalteromonas haloplanktis TAC125 for physiologic studies and drug discovery. Extremophiles. 20(2):227-34.

28. Di Pasquale P, Caterino M, Di Somma A, Squillace M, Rossi E, Landini P, Iebba V, Schippa S, Papa R, Selan L, Artini M, Palamara AT, Duilio A. (2016) Exposure of E. coli to DNA-Methylating Agents Impairs Biofilm Formation and Invasion of Eukaryotic Cells via Down Regulation of the N-Acetylneuraminate Lyase NanA. Front Microbiol. 7:147.