Serafim  Papadimitriou

Andre Lopes Fuly

Associate Professor

biography

Dr.Andre Lopes Fuly was educated in Rio de Janeiro city, Brazil and received my Ph.D. in Biochemistry from the Federal University of Rio de Janeiro (UFRJ) in 2002, following a post-doctoral fellowship at the same University (2004) working with purification of proteins of Brazilian venomous snakes, studying their physico-chemical properties as well as studying their mechanism of action upon coagulation, platelet aggregation, hemorrhage, myotoxicity, and so on. From 2005 until now, I am an Associate Professor at Federal Fluminense University and the chief of a lab, entitled LAVENOTOXI. The projects that are being developed under my supervision have the objective to identify on natural products (plants, seaweed and sponges), molecules able to neutralize some toxic effects of snake venoms, since in Brazil and many other countries in the world, accidents with venomous snakes are a public health public. Moreover, my group tests such molecules on platelet aggregation and blood coagulation system, since vascular diseases are a health problem, as well. In this way, LAVENOTOXI works with Marine Natural Products discovering molecules to be used as antivenom and/or anticoagulation/antiplatelet.

 

Area of Interest

1)Toxinology (Snake venoms)
2)Hemostasis (Platelet aggregation and coagulation)
3)Natural Products
4)Biochemistry
5)Marine Biotecnology


top publication

1) Effect of diterpenes isolated of the marine alga Canistrocarpus cervicornis against some toxic effects of the venom of the Bothrops jararaca snake. Domingos TF, Vallim MA, Cavalcanti DN, Sanchez EF, Teixeira VL, Fuly AL. Molecules. 2015, 18;20(3):3515-26.

2) The red seaweed Plocamium brasiliense shows anti-snake venom toxic effects. da Silva GA, Domingos TF, Fonseca RR, Sanchez EF, Teixeira VL, Fuly AL. J. Venom. Anim. Toxins Incl. Trop. Dis. 2015, 10;21:2.

3) Antiplatelet and anticoagulant effects of diterpenes isolated from the marine alga, Dictyota menstrualis. de Andrade Moura L, Marqui de Almeida AC, Domingos TF, Ortiz-Ramirez F, Cavalcanti DN, Teixeira VL, Fuly AL. Marine Drugs. 2014, 30;12(5):2471-84.

4) Inhibitory effect of the red seaweed Plocamium brasiliense against the toxic effects of Lachesis muta snake venom. Mariana Moreira Claudino, Thaisa Francielle Souza Domingos, Geisiane Alves da Silva, Rainiomar Raimundo Fonseca, Diana Negrao Cavalcanti, Eladio Flores Sanchez, Valeria Laneuville Teixeira, Andre Lopes Fuly. J Appl Phycol. 2014, 26:2047.2054.

5) Purification and biochemical characterization of three myotoxins from Bothrops mattogrossensis snake venom with toxicity against Leishmania and tumor cells. de Moura AA, Kayano AM, Oliveira GA, Setubal SS, Ribeiro JG, Barros NB, Nicolete R, Moura LA, Fuly AL, Nomizo A, da Silva SL, Fernandes CF, Zuliani JP, Stabeli RG, Soares AM, Calderon LA. Biomed Research International. 2014; 2014:195356.

6) Isolation and biochemical characterization of a new thrombin-like serine protease from Bothrops pirajai snake venom. Zaqueo KD, Kayano AM, Simoes-Silva R, Moreira-Dill LS, Fernandes CF, Fuly AL, Maltarollo VG, Honorio KM, da Silva SL, Acosta G, Caballol MA, de Oliveira E, Albericio F, Calderon LA, Soares AM, Stabeli RG. Biomed Research International. 2014; 2014:595186

7) Inhibitory effect of the plant Clusia fluminensis against biological activities of Bothrops jararaca snake venom. de Oliveira EC, Anholeti MC, Domingos TF, Faioli CN, Sanchez EF, de Paiva SR, Fuly AL. Nat. Prod. Commun. 2014; 9(1):21-5

8) Inhibitory effect of plant Manilkara subsericea against biological activities of Lachesis muta snake venom. De Oliveira EC, Fernandes CP, Sanchez EF, Rocha L, Fuly AL. Biomed Research International. 2014; 2014:408068.

9) Appraisal of antiophidic potential of marine sponges against Bothrops jararaca and Lachesis muta venom. Faioli CN, Domingos TF, de Oliveira EC, Sanchez EF, Ribeiro S, Muricy G, Fuly AL. Toxins (Basel). 2013, 5(10):1799-813.

10) Molecular characterization of Lys49 and Asp49 phospholipases A.from snake venom and their antiviral activities against Dengue virus. Cecilio AB, Caldas S, Oliveira RA, Santos AS, Richardson M, Naumann GB, Schneider FS, Alvarenga VG, Estevao-Costa MI, Fuly AL, Eble JA, Sanchez EF. Toxins (Basel). 2013, 15;5(10):1780-98.

11) Biochemical, functional, structural and phylogenetic studies on Intercro, a new isoform phospholipase A2 from Crotalus durissus terrificus snake venom.Vieira LF, Magro AJ, Fernandes CA, de Souza BM, Cavalcante WL, Palma MS, Rosa JC, Fuly AL, Fontes MR, Gallacci M, Butzke DS, Calderon LA, Stabeli RG, Giglio JR, Soares AM. Biochimie. 2013; 95(12):2365-75

12) Antivenom effects of 1,2,3-triazoles against Bothrops jararaca and Lachesis muta snakes. Domingos TF, Moura Lde A, Carvalho C, Campos VR, Jordao AK, Cunha AC, Ferreira VF, de Souza MC, Sanchez EF, Fuly AL. Biomed Research International. 2013; 2013:294289.

13) Biochemical characterization and comparative analysis of two distinct serine proteases from Bothrops pirajai snake venom. Menaldo DL, Bernardes CP, Santos-Filho NA, Moura Lde A, Fuly AL, Arantes EC, Sampaio SV. Biochimie. 2012;94(12):2545-58.

14) Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom. Silveira LB, Marchi-Salvador DP, Santos-Filho NA, Silva FP Jr, Marcussi S, Fuly AL, Nomizo A, da Silva SL, Stabeli RG, Arantes EC, Soares AM. J Pharm Biomed Anal. 2013, 25;73:35-43.

15) Evaluation of marine brown algae and sponges from Brazil as anticoagulant and antiplatelet products. de Andrade Moura L, Ortiz-Ramirez F, Cavalcanti DN, Ribeiro SM, Muricy G, Teixeira VL, Fuly AL. Marine Drugs. 2011;9(8):1346-58.

16) Hypericum brasiliense plant extract neutralizes some biological effects of Bothrops jararaca snake venom. Assafim M, de Coriolano EC, Benedito SE, Fernandes CP, Lobo JF, Sanchez EF, Rocha LM, Fuly AL. J Venom Res. 2011;2:11-6.

17) Molecular characterization of an acidic phospholipase A(2) from Bothrops pirajai snake venom: synthetic C-terminal peptide identifies its antiplatelet region. Teixeira SS, Silveira LB, da Silva FM, Marchi-Salvador DP, Silva FP Jr, Izidoro LF, Fuly AL, Juliano MA, dos Santos CR, Murakami MT, Sampaio SV, da Silva SL, Soares AM. Arch Toxicol. 2011;85(10):1219-33.

18) A phospholipase A. isolated from Lachesis muta snake venom increases the survival of retinal ganglion cells in vitro. da Silva Cunha KC, Fuly AL, de Araujo EG. Toxicon. 2011, 15;57(4):580-5.

19) Anticoagulation and antiplatelet effects of a dolastane diterpene isolated from the marine brown alga Canistrocarpus cervicornis. de Andrade Moura L, Bianco EM, Pereira RC, Teixeira VL, Fuly AL. J Thromb Thrombolysis. 2011; 31(2):235-40.

20) Paralytic activity of lysophosphatidylcholine from saliva of the waterbug Belostoma anurum. Silva-Cardoso L, Caccin P, Magnabosco A, Patron M, Targino M, Fuly A, Oliveira GA, Pereira MH, do Carmo Md, Souza AS, Silva-Neto MA, Montecucco C, Atella GC. J Exp Biol. 2010, 1;213(Pt 19):3305-10.

21) Anticoagulant and fibrinogenolytic properties of the venom of Polybia occidentalis social wasp. Czaikoski PG, Menaldo DL, Marcussi S, Baseggio AL, Fuly AL, Paula RC, Quadros AU, Romao PR, Buschini ML, Cunha FQ, Soares AM, Monteiro MC. Blood Coagul Fibrinolysis. 2010;21(7):653-9.

22) Enzymatic and structural characterization of a basic phospholipase A(2) from the sea anemone Condylactis gigantea. Romero L, Marcussi S, Marchi-Salvador DP, Silva FP Jr, Fuly AL, Stabeli RG, da Silva SL, Gonzalez J, Monte AD, Soares AM. Biochimie. 2010;92(8):1063-71.