Serafim  Papadimitriou

Deborah A. Lebman

Associate Professor


I received my PhD in Molecular Biology from the University of Pennsylvania. Subsequently, I was a postdoctoral in Immunology and Molecular Biology at DNAX Research Institute, Palo Alto, CA. Currently, I am an Associate Professor in the Department of Microbiology and Immunology at Virginia Commonwealth University, Richmond VA. My work has focused on immunology and cancer biology of the gastrointestinal tract with a particular interest in TGF-beta signaling


Area of Interest

1)B cell biology
2)cytokine biology
3)Host pathogen interactions
5)Gastrointestinal cancer

top publication

Lebman, D.A. and C.E. Calkins. Demonstration of active suppressor cells in spleens of young NZB mice. Cell. Immunol. 51:419-423. 1980.
Perussia, B., Lebman, D., Ip, S., Rovera, G., and G. Trinchieri. Terminal differentiation surface antigens of myelomonocytic cells are expressed in human promyelocytic leukemia cells (HL-60) treated with chemical inducers. Blood. 58:836-843. 1981.
Perussia, B., Trinchieri, G., Lebman, D., Jankiewicz, J., Lange, B., and G. Rovera. Monoclonal antibodies that detect differentiation antigens on human myelomoncytic cells. Blood. 59:382-392. 1982.
Lebman, D., Trucco, M., Bottero, L., Lange, B., Pessano, S. and G. Rovera. A monoclonal antibody that detects expression of transferrin receptor in human erythroid precursor cells. Blood. 59:671-678. 1982.
Wiener, E., Lebman, D., Cebra J., and A. Scarpa. Initiation of DNA synthesis in murine B cells is independent of early changes in cytosolic free calcium. Archives Biochem. Biophys. 254:462-471. 1987.
Lebman, D.A., Griffin, P.M., and J.J. Cebra. Relationship between expression of IgA by Peyer\'s patch cells and functional IgA memory cells. J. Exp. Med. 166:1405-1418. 1987.
Lebman, D.A., Fuhrman, J.A., and J.J. Cebra. Intraduodenal application of cholera holotoxin increases the potential of clones from Peyer\'s patch B cells of relevant and unrelated specificities to secrete IgG and IgA. Regional Immunol. 1:32-40. 1988.
Savelkoul, H.F.J., Lebman, D.A., Benner, R., and R.L. Coffman. Increase of precursor frequency and clonal burst size of IgE-secreting cells by Il-4. J. Immunol. 141:749-755. 1988.
Lebman, D.A. and R.L. Coffman. The effects of IL-4 and IL-5 on the IgA response by murine Peyer\'s patch B cell subpopulations. J. Immunol. 141:2050-2056. 1988.
Lebman, D.A. and R.L. Coffman. IL-4 causes isotype switching to IgE in T cell stimulated clonal B cell cultures. J. Exp. Med. 168:853-862. 1988.
Coffman, R.L., Lebman, D.A., and B. Shrader. Transforming growth factor ß specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 170:1039-1045. 1989.
Lebman, D.A., Lee, F.D., and R.L. Coffman. Mechanism for transforming growth factor ß and interleukin 2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures. J. Immunol. 144:952-959. 1990.
Lebman, D.A., Nomura, D.Y., Coffman, R.L., and F.D. Lee. Molecular characterization of germline immunoglobulin A transcripts produced during TGF-ß induced isotype switching. Proc. Nat\'l. Acad. Sci. (USA). 87:3962 3966. 1990.
Gauchat, J.F., Lebman, D.A., Coffman, R.L., Gascan, H., and J.E. DeVries. Structure and expression of germline epsilon transcripts in human B cells induced to switch to IgE expression by IL-4. J. Exp. Medicine. 172:463-474. 1990.
Lebman, D.A., Park, M.J., Fatica, R., and Z. Zhang. Regulation of usage of membrane and secreted 3\' termini of α mRNA differs from μ mRNA. J. Immunol. 148:3282-3289. 1992.
Lebman, D.A., Park, M.J., Hansen-Bundy,S., and A. Pandya. Mechanism for transforming growth factor β regulation of α mRNA in lipopolysaccharide stimulated B cells. Int. Immunol. 6:113-119. 1994.
Edmiston, J.S. and Lebman, D.A. A Transforming growth factor β regulable RNA-binding protein interacts specifically with germline immunoglobulin α transcripts. Int. Immunol. 9:427-433. 1997
Coyle, J.H., Borinstein, S.C., Woodward, E.O., and Lebman, D.A. Predominant usage of the proximal poly (A) site in α mRNAs is not intrinsic to the 3\' termini. Int. Immunol. 10:669-678. 1998.
Coyle, J.H. and Lebman, D.A. Correct immunoglobulin α mRNA processing depends on specific sequence in the Cα3-αM intron. J. Immunol. 164:3659-3665. 2000.
Guilliano, MJ, Foxx-Orenstein, AE, and Lebman, DA. The microenvironment of human Peyer’s patches inhibits the increase in CD38 expression associated with the germinal center reaction. J. Immunol. 166:2179-2185. 2001.
Lebman, DA, Edmiston, JA, Chung, TD, and Snyder, SR. Heterogeneity in the transforming growth factor  response of esophageal cancer cells. Int. J. Onc. 20:1241-1246. 2002.
Kim,AH, Lebman,DA, Dietz,CM, Snyder, SR, Eley, KW, Chung,TD. Transforming growth factor- is an endogenous radiosresistance factor in the esophageal adenocarcinoma cell line OE-33. Int. J. Onc. 23: 1593-1599. 2003.
Edmiston, JS, Yeudall, WA, Chung, TD, Lebman, DA. Inability of TGF to cause SnoN degradation leads to resistance to TGF induced growth arrest in esophageal cancer cells. Cancer Research 65:4782-4788. 2005.
Miller, AV; Alvarez, SE, Spiegel, S, Lebman, DA. Sphingosine Kinases and Sphingosine-1-Phosphate are Critical for TGF- Induced ERK1/2 Activation and Promotion of Migration and Invasion of Esophageal Cancer Cells. Mol Cell Biol 28: 4142-51. 2008.
Holden,CA, Yuan, Q, Yeudall, WA, Lebman, DA, Yang,H. Surface Engineering of Macrophages with Nanoparticles to Generate a Cell-Nanoparticle Hybrid Vehicle for Hypoxia Targeted Drug Delivery. Int J Nanomedicine 5:25-36. 2010.
Malhotra AK, Carter, RF, Lebman, DA, Carter, DS, Riaz OJ, Aboutanos, MB, Duane, TM Ivatury RR. Preservation of Splenic Immunocompetence after Splenic Artery Angioembolization for Blunt Splenic Injury. J Trauma 69:1126-1131. 2010
Wu, J, Mukherjee,A, Lebman, DA, Fang, X. Lysophosphatidic acid upregulates expression of p21Waf1 to mediate the cytostatic response of breast and ovarian cancer cells to transforming growth factor beta. Mol Cancer Res 9:1562-1570, 2011.
Dcona MM, Mitra D, Goehe RW, Gewirtz DA, Lebman DA, Hartman MC. Photocaged permeability: a new strategy for controlled drug release. Chem Commun 48:4755-4777, 2012.
Wu, J, Mukherjee,A, Lebman, DA, Fang, X. Gene Expression of lysophosphatidic acid receptor 1 is a target for transforming growth factor beta. Oncogene 32:3198-3206, 2013.