Journal of Medicinal Chemistry and Toxicology
Antibacterial Activities of Nanoparticles of Titanium dioxide, Intrinsic and Doped With Indium and Iron
- 1Department of Chemistry, Mekelle University College of Natural and Computational Science, Ethiopia
- 1Department of Biology, Mekelle University, Ethiopia
Teklit Gebregiorgis Amabye, Department of Chemistry, Mekelle University College of Natural and Computational Science, Ethiopia, E-mail: email@example.com
Amabye, T.G, et al. Antibacterial Activities of Nanoparticles of Titanium Dioxide, Intrinsic and Doped with Indium and Iron. (2016) J Med Chem Tox 1(1): 8-14.
© 2016 Amabye, T.G. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsDope; Nanoparticles; Titanium oxide
The need for new antimicrobial compounds has been attention on developing new and emerging materials based on nanoparticles with antimicrobial activity. The aim of this research was to evaluate the antibacterial activities of nanoparticles of titanium dioxide, intrinsic and doped with Indium and Iron in Escherichia coli and Staphylococcus aureus. The bacteriostatic effect of TiO2 nanoparticles (two samples), TiO2: Fe and TiO2:In with concentrations of 50, 250 500 μg/ml. It was observed by optical density measurements. The bactericidal effect was determined by plate count agar Muller-Hinton, where they were incubated for 12 hours: 50 μl of bacterial suspension (concentration 1.5 x 106 bacteria/ml), concentration 50 μl of nanoparticles suspended at concentrations between 39 and 2500 μg/ml. Then, to 10 - 6 dilutions were made and plated on agar for colony counts. There were significant decreases P < 0.05 in the bacterial optical densities with respect to control, using TiO2 nanoparticles prepared with different contents of acetic acid at concentrations of 250 and 500 μg/ml versus E. coli and S. aureus. In the plate counts, there was a significant reduction, P < 0.05 in the number of CFU of E. coli using TiO2 nanoparticles (50% AcAc) in concentrations 39 to 2500 μg/ml; in the case of S. aureus decrease seen in concentrations 78 to 2500 μg/ml. In both bacteria, we observed decreased bacterial growth with TiO2 nanoparticles at concentrations of 156 - 2500 μg/ml. The two variants of preparing TiO2 nanoparticles have higher intrinsic activity against E. coli and S. aureus, while nanoparticles doped with Indium and Iron, not power the antibacterial effect.