Affiliation

Department of Biochemistry, ESI Postgraduate Institute of Medical Sciences & Research, Basaidarapur, New Delhi-110015, India

Corresponding Author

Sarika Arora, Associate Professor, Department of Biochemistry, ESI Postgraduate Institute of Medical Sciences & Research, New Delhi-110015, India, Tel: +91-9811266400; E-mail: sarikaarora08@rediffmail.com

Citation

Sarika, A., et al. Association between Postsprandial Triglyceride Levels and Urinary Albumin Excretion in Type II Diabetic Subjects - A Case-Control Study in North Indian Population (2014) J Diabetes Obes 1(2): 1- 7.

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© 2014 Sarika A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Abstract

Aim: To evaluate and correlate 2-hour postprandial lipid profile and urine albumin excretion in patients with type II Diabetes Mellitus.

Method: This case-control study included 148 subjects with Type II Diabetes mellitus and 96 age and gender matched healthy controls. Fasting and 2-hour postprandial blood samples were collected from all subjects and analyzed for plasma glucose, serum insulin, serum cholesterol, triglycerides and high-density lipoproteins. In addition fasting samples were analyzed for glycated haemoglobin (HbA1c) and kidney function tests. Percentage retention of triglyceride in plasma at the end of two hours and HOMA-IR as a measure of Insulin resistance was calculated. Spot urine sample collected from all subjects within two hours waiting period was analyzed for urine albumin/ creatinine ratio. Statistical evaluation of data was done on SPSS and Medcalc on-line software.

Result: Plasma glucose, insulin and HbA1c levels were significantly higher in diabetic subjects as compared to control group (p < 0.01). Serum cholesterol and HDL levels did not have a significant difference in fasting and postprandial state in both groups. The difference in triglyceride levels between study and control group was insignificant in fasting state (p = 0.051) but highly significant in postprandial state (pf <0.001). Percentage triglyceride retention in plasma after 2 hours was significantly higher in diabetic patients [16.43 ± 28.25%] as compared to control group [2.56 ± 19.17%] (p = 0.002). Postprandial serum triglyceride levels in diabetic subjects showed a highly significant positive correlation with urinary albumin excretion in these subjects (r = 0.444, p < 0.001).Odds ratio for presence of hypertriglyceridemia in patients with microalbuminuria was 18.667 (95% CI of 6.64 to 52.45, z-static -5.55, P < 0.0001).

Conclusion: Diabetic subjects excreting micro-albumin in urine have exaggerated postprandial lipidemia as compared to patients with no micro-albumin excretion and normal subjects. This may be regarded as one of the mechanisms by which microalbuminuria in diabetic patients contributes to increased cardiovascular risk.